Cardiovascular disease and cumulative incidence of cognitive impairment in the Health and Retirement Study

Background We sought to examine whether people with a diagnosis of cardiovascular disease (CVD) experienced a greater incidence of subsequent cognitive impairment (CI) compared to people without CVD, as suggested by prior studies, using a large longitudinal cohort. Methods We employed Health and Ret...

Full description

Saved in:
Bibliographic Details
Published in:BMC geriatrics Vol. 21; no. 1; pp. 274 - 9
Main Authors: Covello, Allyson L., Horwitz, Leora I., Singhal, Shreya, Blaum, Caroline S., Li, Yi, Dodson, John A.
Format: Journal Article
Language:English
Published: London BioMed Central 26.04.2021
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Age
Aged
Aging
Angina
Cardiac arrhythmia
Cardiovascular disease
Cardiovascular diseases
Chronic illnesses
Cognition
Cognition & reasoning
Cognition disorders
Cognitive ability
Complications and side effects
Congestive heart failure
Coronary artery disease
Death
Diagnosis
Gender
Geriatric cardiology
Geriatrics
Geriatrics/Gerontology
Health aspects
Heart failure
Hispanic people
Medicine
Medicine & Public Health
Memory
Myocardial infarction
Older people
Polls & surveys
Population
Psychological aspects
Rehabilitation
Research Article
Risk factors
Statistics
United States
Geriatric cardiology
Cardiovascular disease
Cognition
ISSN:1471-2318, 1471-2318
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background We sought to examine whether people with a diagnosis of cardiovascular disease (CVD) experienced a greater incidence of subsequent cognitive impairment (CI) compared to people without CVD, as suggested by prior studies, using a large longitudinal cohort. Methods We employed Health and Retirement Study (HRS) data collected biennially from 1998 to 2014 in 1305 U.S. adults age ≥ 65 newly diagnosed with CVD vs. 2610 age- and gender-matched controls. Diagnosis of CVD was adjudicated with an established HRS methodology and included self-reported coronary heart disease, angina, heart failure, myocardial infarction, or other heart conditions. CI was defined as a score  <  11 on the 27-point modified Telephone Interview for Cognitive Status. We examined incidence of CI over an 8-year period using a cumulative incidence function accounting for the competing risk of death. Results Mean age at study entry was 73 years, 55% were female, and 13% were non-white. Cognitive impairment developed in 1029 participants over 8 years. The probability of death over the study period was greater in the CVD group (19.8% vs. 13.8%, absolute difference 6.0, 95% confidence interval 2.2 to 9.7%). The cumulative incidence analysis, which adjusted for the competing risk of death, showed no significant difference in likelihood of cognitive impairment between the CVD and control groups (29.7% vs. 30.6%, absolute difference − 0.9, 95% confidence interval − 5.6 to 3.7%). This finding did not change after adjusting for relevant demographic and clinical characteristics using a proportional subdistribution hazard regression model. Conclusions Overall, we found no increased risk of subsequent CI among participants with CVD (compared with no CVD), despite previous studies indicating that incident CVD accelerates cognitive decline.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1471-2318
1471-2318
DOI:10.1186/s12877-021-02191-0