Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes

Background Organic cation transporter 1 primarily governs the action of metformin in the liver. There are considerable inter-individual variations in metformin response. In light of this, it is crucial to obtain a greater understanding of the influence of OCT1 expression or polymorphism in the conte...

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Bibliographic Details
Published in:	BMC endocrine disorders Vol. 22; no. 1; pp. 140 - 11
Main Authors:	Kawoosa, Fizalah, Shah, Zafar A., Masoodi, Shariq R., Amin, Asif, Rasool, Roohi, Fazili, Khalid M., Dar, Abid Hamid, Lone, Asif, ul Bashir, Samir
Format:	Journal Article
Language:	English
Published:	London BioMed Central 26.05.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	AMPK Antidiabetics Care and treatment Cluster analysis Diabetes Diabetes mellitus (non-insulin dependent) Endocrinology Ethylenediaminetetraacetic acid Gene expression Genetic aspects Genetic diversity Genotyping Hypoglycemic agents Ligands Liver Medicine Medicine & Public Health Metabolic Diseases Metformin Monoclonal antibodies Mutagenesis Oct-1 protein Organic cation transporter Organic cation transporter 1(OCT-1/SLC22A1) Patients Proteins RNA rology Simulation Single-nucleotide polymorphism Type 2 diabetes India United States > US AMPK Organic cation transporter 1(OCT-1/SLC22A1) Metformin
ISSN:	1472-6823, 1472-6823
Online Access:	Get full text
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