Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations

The B vitamins are components of one-carbon metabolism (OCM) that contribute to DNA synthesis and methylation. Homocysteine, a by-product of OCM, has been associated with coronary heart disease, stroke and neurological disease. To investigate genetic factors that affect circulating vitamin B6, vitam...

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Veröffentlicht in:	American journal of human genetics Jg. 84; H. 4; S. 477
Hauptverfasser:	Tanaka, Toshiko, Scheet, Paul, Giusti, Betti, Bandinelli, Stefania, Piras, Maria Grazia, Usala, Gianluca, Lai, Sandra, Mulas, Antonella, Corsi, Anna Maria, Vestrini, Anna, Sofi, Francesco, Gori, Anna Maria, Abbate, Rosanna, Guralnik, Jack, Singleton, Andrew, Abecasis, Goncalo R, Schlessinger, David, Uda, Manuela, Ferrucci, Luigi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.04.2009
Schlagworte:	Adult Aged Aged, 80 and over Alkaline Phosphatase - genetics Female Folic Acid - blood Fucosyltransferases - genetics Galactoside 2-alpha-L-fucosyltransferase Genome-Wide Association Study Homocysteine - blood Humans Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Neoplasm Proteins - genetics Polymorphism, Single Nucleotide Receptors, Cell Surface - genetics Transcobalamins - genetics Vitamin B 12 - blood Vitamin B 6 - blood
ISSN:	1537-6605, 1537-6605
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