Efficacy and safety of lenalidomide in HIV-associated cryptococcal meningitis patients with persistent intracranial inflammation: an open-label, single-arm, prospective interventional study

Background Patients with human immunodeficiency virus-associated cryptococcal meningitis (HIV-CM) have persistent intracranial inflammation despite negative cerebrospinal fluid (CSF) fungal cultures after optimal treatment for CM, which could be devastating for the central nervous system. However, a...

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Bibliographic Details
Published in:	Journal of neuroinflammation Vol. 20; no. 1; pp. 38 - 11
Main Authors:	Wan, Zhikai, Tao, Ran, Hui, Jiangjin, Liu, Xiang, Peng, Xiaorong, Guo, Yongzheng, Zhu, Xueling, Huang, Ying, Zhu, Biao
Format:	Journal Article
Language:	English
Published:	London BioMed Central 15.02.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adverse events Albumin Albumins - therapeutic use Antifungal agents Apolipoproteins Biomedical and Life Sciences Biomedicine Blood cell count Brain damage Care and treatment Central nervous system Cerebrospinal fluid Clinical outcomes Clinical trials Colony-stimulating factor Cryptococcal meningitis Cytokines Diagnosis Diagnostic tests Fatalities Granulocytes Growth factors Health aspects HIV HIV Infections - complications HIV Infections - drug therapy HIV patients HIV-associated cryptococcal meningitis Human immunodeficiency virus Humans Immune system Immunology Immunomodulatory drug Immunotherapy Induction therapy Infectious diseases Inflammation Inflammation - complications Intracranial pressure Laboratories Lenalidomide Lenalidomide - therapeutic use Leukocytes (granulocytic) Magnetic resonance imaging Medical imaging Meningitis Meningitis, Cryptococcal - cerebrospinal fluid Meningitis, Cryptococcal - complications Meningitis, Cryptococcal - drug therapy Neurobiology Neuroimaging Neurology Neurosciences Patients Permeability Persistent intracranial inflammation Prospective Studies Proteins Remission Risk factors Targeted cancer therapy Tumor necrosis factor-TNF Values Vital signs China United States > US Persistent intracranial inflammation Lenalidomide HIV-associated cryptococcal meningitis Immunomodulatory drug
ISSN:	1742-2094, 1742-2094
Online Access:	Get full text
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