Newly identified T cell subsets in mechanistic studies of food immunotherapy

Allergen-specific immunotherapy has shown promise for the treatment of food allergy and is currently being evaluated in clinical trials. Although immunotherapy can induce desensitization, the mechanisms underlying this process are not completely understood. Recent advances in high-throughput technol...

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Vydáno v:The Journal of clinical investigation Ročník 129; číslo 4; s. 1431 - 1440
Hlavní autoři: Sampath, Vanitha, Nadeau, Kari C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States American Society for Clinical Investigation 01.04.2019
Témata:
Allergens
Allergy
Analysis
Asthma
B cells
Biomedical research
Clinical trials
Cytokines
Food allergies
Food hypersensitivity
Food Hypersensitivity - immunology
Food Hypersensitivity - pathology
Food Hypersensitivity - therapy
Humans
Immunological tolerance
Immunology
Immunotherapy
Lymphocytes
Lymphocytes T
Metabolites
Patient outcomes
Prevalence studies (Epidemiology)
Probiotics
Review Series
Shellfish
T cells
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - pathology
Technology
Th1 Cells - immunology
Th1 Cells - pathology
Th2 Cells - immunology
Th2 Cells - pathology
United States
United States > US
ISSN:0021-9738, 1558-8238, 1558-8238
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Popis
Shrnutí:Allergen-specific immunotherapy has shown promise for the treatment of food allergy and is currently being evaluated in clinical trials. Although immunotherapy can induce desensitization, the mechanisms underlying this process are not completely understood. Recent advances in high-throughput technologies along with concomitant advances in data analytics have enabled monitoring of cells at the single-cell level and increased the research focus on upstream cellular factors involved in the efficacy of immunotherapy, particularly the role of T cells. As our appreciation of different T cell subsets and their plasticity increases, the initial simplistic view that restoring Th1/Th2 balance by decreasing Th2 or increasing Th1 responses can ameliorate food allergy is being enhanced by a more complex model involving other T cell subsets, particularly Tregs. In this Review, we focus on the current understanding of T cell functions in food allergy, tolerance, and immunotherapy.
Bibliografie:ObjectType-Article-1
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ISSN:0021-9738
1558-8238
1558-8238
DOI:10.1172/JCI124605