Serum lipids profiling perturbances in patients with ischemic heart disease and ischemic cardiomyopathy

Background Ischemic heart disease (IHD) is a common cardiovascular disorder associated with inadequate blood supply to the myocardium. Chronic coronary ischemia leads to ischemic cardiomyopathy (ICM). Despite their rising prevalence and morbidity, few studies have discussed the lipids alterations in...

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Vydáno v:Lipids in health and disease Ročník 19; číslo 1; s. 89 - 10
Hlavní autoři: Yang, Lin, Wang, Liang, Deng, Yangyang, Sun, Lizhe, Lou, Bowen, Yuan, Zuyi, Wu, Yue, Zhou, Bo, Liu, Junhui, She, Jianqing
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 09.05.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Adult
Aged
Analysis
Biomarkers
Biomedical and Life Sciences
Blood lipids
Cardiac patients
Cardiomyopathies - blood
Cardiomyopathies - diagnosis
Cardiomyopathies - pathology
Cardiomyopathy
Cardiovascular disease
Cardiovascular disorders
Care and treatment
Case-Control Studies
Ceramide
Ceramides - blood
Ceramides - classification
Clinical Nutrition
Coronary artery disease
Female
Heart diseases
Humans
Ions
Ischemia
Ischemic cardiomyopathy
Ischemic heart disease
Life Sciences
Lipid Metabolism
Lipidology
Lipidomics
Lipids
Lysophospholipids - blood
Lysophospholipids - classification
Male
Medical Biochemistry
Medical imaging
Metabolites
Metabolomics
Metabolomics - methods
Middle Aged
Morbidity
Myocardial diseases
Myocardial ischemia
Myocardial Ischemia - blood
Myocardial Ischemia - diagnosis
Myocardial Ischemia - pathology
Myocardium
Myocardium - metabolism
Myocardium - pathology
Patients
Phosphatidylcholines - blood
Phosphatidylcholines - classification
Prevalence studies (Epidemiology)
Serum lipids
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Sphingomyelins - blood
Sphingomyelins - classification
Taiwan
Ischemic heart disease
Biomarkers
Lipidomics
Cardiovascular disorders
Ischemic cardiomyopathy
ISSN:1476-511X, 1476-511X
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Shrnutí:Background Ischemic heart disease (IHD) is a common cardiovascular disorder associated with inadequate blood supply to the myocardium. Chronic coronary ischemia leads to ischemic cardiomyopathy (ICM). Despite their rising prevalence and morbidity, few studies have discussed the lipids alterations in these patients. Methods In this cross-sectional study, we analyzed serum lipids profile in IHD and ICM patients using a lipidomics approach. Consecutive consenting patients admitted to the hospital for IHD and ICM were enrolled. Serum samples were obtained after overnight fasting. Non-targeted metabolomics was applied to demonstrate lipids metabolic profile in control, IHD and ICM patients. Results A total of 63 and 62 lipids were detected in negative and positive ion mode respectively. Among them, 16:0 Lyso PI, 18:1 Lyso PI in negative ion mode, and 19:0 Lyso PC, 12:0 SM d18:1/12:0, 15:0 Lyso PC, 17:0 PC, 18:1–18:0 PC in positive ion mode were significantly altered both in IHD and ICM as compared to control. 13:0 Lyso PI, 18:0 Lyso PI, 16:0 PE, 14:0 PC DMPC, 16:0 ceramide, 18:0 ceramide in negative ion mode, and 17:0 PE, 19:0 PC, 14:0 Lyso PC, 20:0 Lyso PC, 18:0 PC DSPC, 18:0–22:6 PC in positive ion mode were significantly altered only in ICM as compared to IHD and control. Conclusion Using non-targeted lipidomics profiling, we have successfully identified a group of circulating lipids that were significantly altered in IHD and ICM. The lipids metabolic signatures shed light on potential new biomarkers and therapeutics for preventing and treating ICM.
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ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-020-01269-9