Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients

Background Tumour hypoxia promotes an aggressive tumour phenotype and enhances resistance to anticancer treatments. Following the recent observation that the mitochondrial inhibitor atovaquone increases tumour oxygenation in NSCLC, we sought to assess whether atovaquone affects tumour subregions dif...

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Veröffentlicht in:	EJNMMI research Jg. 11; H. 1; S. 130 - 10
Hauptverfasser:	Bourigault, Pauline, Skwarski, Michael, Macpherson, Ruth E., Higgins, Geoff S., McGowan, Daniel R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Berlin/Heidelberg Springer Berlin Heidelberg 29.12.2021 Springer Nature B.V SpringerOpen
Schlagworte:	Atovaquone Cancer therapies Cardiac Imaging Coronary vessels FMISO Gene expression Hypoxia Imaging Lung cancer Medical imaging Medicine Medicine & Public Health Metabolism Monte Carlo simulation Non-small cell lung cancer Nuclear Medicine Oncology Original Research Orthopedics Oxygenation Patients PET Positron emission Radiation therapy Radiology Tomography Tumors Tumour hypoxia FMISO Atovaquone Tumour hypoxia PET Non-small cell lung cancer
ISSN:	2191-219X, 2191-219X
Online-Zugang:	Volltext
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