Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial

Objectives SARS-Cov-2 virus preferentially binds to the Angiotensin Converting Enzyme 2 (ACE2) on alveolar epithelial type II cells, initiating an inflammatory response and tissue damage which may impair surfactant synthesis contributing to alveolar collapse, worsening hypoxia and leading to respira...

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Bibliographic Details
Published in:	Current controlled trials in cardiovascular medicine Vol. 21; no. 1; pp. 1014 - 3
Main Authors:	Dushianthan, Ahilanandan, Clark, Howard, Madsen, Jens, Mogg, Robin, Matthews, Lewis, Berry, Lee, de la Serna, Jorge Bernardino, Batchelor, James, Brealey, David, Hussell, Tracy, Porter, Joanna, Djukanovic, Ratko, Feelisch, Martin, Postle, Anthony, Grocott, Michael P. W.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 10.12.2020 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adult Biomedicine Case-Control Studies Coronaviruses COVID-19 COVID-19 - drug therapy COVID-19 - epidemiology COVID-19 - mortality COVID-19 - virology COVID-19 study protocols Drug dosages Feasibility Studies Health Sciences Humans Intensive Care Intensive Care Units - statistics & numerical data Letter London - epidemiology mechanical ventilation Medicine Medicine & Public Health Mortality - trends Nebulizers and vaporizers Nebulizers and Vaporizers - standards Nebulizers and Vaporizers - statistics & numerical data protocol Randomised controlled trial Respiration, Artificial - methods Respiratory Insufficiency - metabolism Respiratory Insufficiency - physiopathology Respiratory Insufficiency - therapy Safety SARS-CoV-2 - genetics Severe acute respiratory syndrome coronavirus 2 Statistics for Life Sciences Surface active agents Surface-Active Agents - administration & dosage Surface-Active Agents - chemistry Surface-Active Agents - therapeutic use surfactant Surfactants Testing Treatment Outcome Ventilation - statistics & numerical data Ventilators London United Kingdom COVID-19 protocol nebulisation mechanical ventilation Randomised controlled trial Intensive Care surfactant
ISSN:	1745-6215, 1745-6215
Online Access:	Get full text
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