TCF7L2 lncRNA: a link between bipolar disorder and body mass index through glucocorticoid signaling

Bipolar disorder (BD) and obesity are highly comorbid. We previously performed a genome-wide association study (GWAS) for BD risk accounting for the effect of body mass index (BMI), which identified a genome-wide significant single-nucleotide polymorphism (SNP) in the gene encoding the transcription...

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Veröffentlicht in:	Molecular psychiatry Jg. 26; H. 12; S. 7454 - 7464
Hauptverfasser:	Liu, Duan, Nguyen, Thanh Thanh Le, Gao, Huanyao, Huang, Huaizhi, Kim, Daniel C, Sharp, Brenna, Ye, Zhenqing, Lee, Jeong-Heon, Coombes, Brandon J, Ordog, Tamas, Wang, Liewei, Biernacka, Joanna M, Frye, Mark A, Weinshilboum, Richard M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.12.2021
Schlagworte:	Astrocytes Bipolar disorder Bipolar Disorder - genetics Body Mass Index Central nervous system Chromatin Diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Gene polymorphism Genes Genome-wide association studies Genome-Wide Association Study Genomes Glucocorticoids Humans Immunoprecipitation Induced Pluripotent Stem Cells - metabolism Insulin Non-coding RNA Pancreas Pluripotency Polymorphism, Single Nucleotide - genetics Quantitative trait loci RNA, Long Noncoding - genetics Single-nucleotide polymorphism Stem cells Transcription Factor 7-Like 2 Protein - genetics Transcription Factor 7-Like 2 Protein - metabolism
ISSN:	1359-4184, 1476-5578, 1476-5578
Online-Zugang:	Volltext
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