Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis

Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood. Here, we demonstrate 7-dehydrocholesterol reductase (DHCR7), the terminal enzyme of cholesterol biosynthesis, as a regulator of...

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Bibliographic Details
Published in:	Nature communications Vol. 15; no. 1; pp. 2195 - 14
Main Authors:	Yamada, Naoya, Karasawa, Tadayoshi, Ito, Junya, Yamamuro, Daisuke, Morimoto, Kazushi, Nakamura, Toshitaka, Komada, Takanori, Baatarjav, Chintogtokh, Saimoto, Yuma, Jinnouchi, Yuka, Watanabe, Kazuhisa, Miura, Kouichi, Yahagi, Naoya, Nakagawa, Kiyotaka, Matsumura, Takayoshi, Yamada, Ken-ichi, Ishibashi, Shun, Sata, Naohiro, Conrad, Marcus, Takahashi, Masafumi
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.03.2024 Nature Publishing Group Nature Portfolio
Subjects:	13 14/19 38/43 49/40 631/80/82 64/60 692/4020/4021/288/2032 692/699/1503/1607 7-Dehydrocholesterol reductase 82/1 82/58 82/80 Ablation Acetaminophen Animals Biosynthesis Cholesterol Cyclodextrins Electron paramagnetic resonance Electron spin Electron spin resonance Electrons Enzymes Ferroptosis Hepatocellular carcinoma Hepatocytes Humanities and Social Sciences Humans Injury prevention Ischemia Liver Liver cancer Liver Diseases Liver failure Metabolites Mice multidisciplinary Oxidation Oxidoreductases Acting on CH-CH Group Donors - metabolism Pathophysiology Reductases Regulatory mechanisms (biology) Reperfusion Science Science (multidisciplinary) Spin resonance Substrate inhibition trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride β-Cyclodextrin
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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