Cellular reprogramming and epigenetic rejuvenation

Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedi...

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Bibliographic Details
Published in:Clinical epigenetics Vol. 13; no. 1; p. 170
Main Authors: Simpson, Daniel J., Olova, Nelly N., Chandra, Tamir
Format: Journal Article
Language:English
Published: London BioMed Central 06.09.2021
BioMed Central Ltd
Springer Nature B.V
Subjects:
Age
Aged
Aged, 80 and over
Aging
Aging - genetics
Biomedical and Life Sciences
Biomedicine
Cancer
Cellular Reprogramming - genetics
Cellular Senescence - genetics
Cloning
DNA Methylation - genetics
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Epigenomics
Female
Fibroblasts
Gene expression
Gene Function
Genetic engineering
Human Genetics
Humans
Male
Morphology
Physiology
Pluripotency
Regenerative Medicine
Regenerative Medicine and Epigenetics
Rejuvenation - physiology
Review
Sheep
Stem cells
Telomerase
Cellular reprogramming
Epigenetic clocks
Ageing
Rejuvenation
Reprogramming-induced rejuvenation
Transient reprogramming
Epigenetic age
ISSN:1868-7075, 1868-7083, 1868-7083, 1868-7075
Online Access:Get full text
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Summary:Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i.e. somatic cell identity is lost as cells are converted to a pluripotent state. Separating the rejuvenative properties of reprogramming from dedifferentiation is a promising prospect, termed epigenetic rejuvenation. Reprogramming-induced rejuvenation strategies currently involve using Yamanaka factors (typically transiently expressed to prevent full dedifferentiation) and are promising candidates to safely reduce biological age. Here, we review the development and potential of reprogramming-induced rejuvenation as an anti-ageing strategy.
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ISSN:1868-7075
1868-7083
1868-7083
1868-7075
DOI:10.1186/s13148-021-01158-7