Capsaicin-evoked CGRP release from rat buccal mucosa: development of a model system for studying trigeminal mechanisms of neurogenic inflammation

Many of the physiological hallmarks associated with neurogenic inflammatory processes in cutaneous tissues are similarly present within orofacial structures. Such attributes include the dependence upon capsaicin‐sensitive sensory neurons and the involvement of certain inflammatory mediators derived...

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Bibliographic Details
Published in:	The European journal of neuroscience Vol. 14; no. 7; pp. 1113 - 1120
Main Authors:	Flores, Christopher M., Leong, Anthony S., O. Dussor, Gregory, Hargreaves, Kenneth M., Kilo, Sonja
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01.10.2001
Subjects:	Animals Bradykinin - pharmacology Calcimycin - pharmacology Calcitonin Gene-Related Peptide - metabolism Calcium - metabolism Capsaicin - analogs & derivatives Capsaicin - pharmacology Dinoprostone - pharmacology Disease Models, Animal Dose-Response Relationship, Drug exocytosis Histamine - pharmacology in vitro superfusion Inflammation Mediators - metabolism Ionophores - pharmacology Male Mouth Mucosa - drug effects Mouth Mucosa - innervation Mouth Mucosa - metabolism Neurogenic Inflammation - chemically induced Neurogenic Inflammation - metabolism Neurogenic Inflammation - physiopathology neuropeptide nociceptor Nociceptors - drug effects Nociceptors - metabolism Organ Culture Techniques pain Pain Measurement - drug effects Potassium Chloride - pharmacology Rats Rats, Sprague-Dawley sensory neuron Serotonin - pharmacology Trigeminal Nerve - drug effects Trigeminal Nerve - metabolism
ISSN:	0953-816X, 1460-9568
Online Access:	Get full text
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