Immune characterization of the HBHA-specific response in Mycobacterium tuberculosis-infected patients with or without HIV infection

RD1-based Interferon-γ Release Assays (IGRAs) cannot distinguish latent from active tuberculosis (TB) disease. Conversely, a positive response to heparin-binding haemagglutinin (HBHA)-based IGRAs, among TB-infected subjects, correlates with Mycobacterium tuberculosis (Mtb) containment and low risk o...

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Vydáno v:	PloS one Ročník 12; číslo 8; s. e0183846
Hlavní autoři:	Chiacchio, Teresa, Delogu, Giovanni, Vanini, Valentina, Cuzzi, Gilda, De Maio, Flavio, Pinnetti, Carmela, Sampaolesi, Alessandro, Antinori, Andrea, Goletti, Delia
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 24.08.2017 Public Library of Science (PLoS)
Témata:	Adult Antigens Biology and Life Sciences Blood CCR7 protein CD4 antigen CD4-Positive T-Lymphocytes - metabolism CD45RA antigen CD8 antigen CD8-Positive T-Lymphocytes - metabolism Containment Cytokines - metabolism Cytometry Disease Progression Drug resistance Enzyme-Linked Immunosorbent Assay Epidemiology Female Flow Cytometry Health aspects Hemagglutinins Heparin HIV HIV infections HIV Infections - complications Human immunodeficiency virus Humans Immune response Immunology Infections Infectious diseases Interferon Interferon-gamma - biosynthesis Interleukins Lectins - therapeutic use Leukocytes (mononuclear) Lymphocytes T Male Medicine and Health Sciences Memory cells Middle Aged Mycobacterium tuberculosis Patients Peripheral blood mononuclear cells Prospective Studies Stimulation Tuberculosis Tuberculosis - complications Tuberculosis - drug therapy Tuberculosis - pathology Tumor necrosis factor Vaccines Italy
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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