Smc5/6 maintains stalled replication forks in a recombination-competent conformation

The Smc5/6 structural maintenance of chromosomes complex is required for efficient homologous recombination (HR). Defects in Smc5/6 result in chromosome mis‐segregation and fragmentation. By characterising two Schizosaccharomyces pombe smc6 mutants, we define two separate functions for Smc5/6 in HR....

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Bibliographic Details
Published in:	The EMBO journal Vol. 28; no. 2; pp. 144 - 155
Main Authors:	Irmisch, Anja, Ampatzidou, Eleni, Mizuno, Ken'ichi, O'Connell, Matthew J, Murray, Johanne M
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 21.01.2009 Nature Publishing Group UK Springer Nature B.V Nature Publishing Group
Subjects:	Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology Chromatin - genetics Chromatin - physiology Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - physiology Chromosomes Deoxyribonucleic acid DNA DNA Damage DNA Replication - genetics DNA Replication - physiology EMBO13 Genetic recombination Genomics Molecular biology Mutation Nucleic Acid Conformation Rad52 Rad52 DNA Repair and Recombination Protein - genetics Rad52 DNA Repair and Recombination Protein - metabolism recombination Recombination, Genetic replication fork stalling Schizosaccharomyces - genetics Schizosaccharomyces - physiology Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - physiology Smc5/6 replication fork stalling Rad52 recombination Smc5/6
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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