Clinical neurocardiology defining the value of neuroscience‐based cardiovascular therapeutics

The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience‐based cardiovascular therapeutics is increasingly evident. This White Paper reviews the...

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Bibliographic Details
Published in:The Journal of physiology Vol. 594; no. 14; pp. 3911 - 3954
Main Authors: Shivkumar, Kalyanam, Ajijola, Olujimi A., Anand, Inder, Armour, J. Andrew, Chen, Peng‐Sheng, Esler, Murray, Ferrari, Gaetano M., Fishbein, Michael C., Goldberger, Jeffrey J., Harper, Ronald M., Joyner, Michael J., Khalsa, Sahib S., Kumar, Rajesh, Lane, Richard, Mahajan, Aman, Po, Sunny, Schwartz, Peter J., Somers, Virend K., Valderrabano, Miguel, Vaseghi, Marmar, Zipes, Douglas P.
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 15.07.2016
John Wiley and Sons Inc
Subjects:
Animals
Autonomic Nervous System - physiology
Cardiovascular Conditions, Disorders and Treatments
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - therapy
Cardiovascular Physiology
Heart - innervation
Heart - physiology
Heart - physiopathology
Humans
Neuroscience
Neurosciences
Special section reviews: Cardiac autonomic control in health and disease
White Paper
ISSN:0022-3751, 1469-7793, 1469-7793
Online Access:Get full text
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Summary:The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience‐based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.
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ISSN:0022-3751
1469-7793
1469-7793
DOI:10.1113/JP271870