Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error‐free, and th...

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Veröffentlicht in:	The EMBO journal Jg. 28; H. 4; S. 383 - 393
Hauptverfasser:	Shachar, Sigal, Ziv, Omer, Avkin, Sharon, Adar, Sheera, Wittschieben, John, Reißner, Thomas, Chaney, Stephen, Friedberg, Errol C, Wang, Zhigang, Carell, Thomas, Geacintov, Nicholas, Livneh, Zvi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Chichester, UK John Wiley & Sons, Ltd 18.02.2009 Nature Publishing Group UK Springer Nature B.V Nature Publishing Group
Schlagworte:	Animals carcinogenesis Catalysis Cell Line, Tumor Cellular biology Deoxyribonucleic acid Dimerization DNA DNA - chemistry DNA - metabolism DNA Damage DNA polymerase DNA repair DNA Replication DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - metabolism Epistasis, Genetic Genomics Humans Kinetics lesion bypass Lesions Mammals Mice Molecular biology Mutagenesis Pyrimidine Dimers - chemistry RNA, Small Interfering - metabolism Xeroderma Pigmentosum Group A Protein - metabolism carcinogenesis DNA repair mutagenesis DNA damage lesion bypass
ISSN:	0261-4189, 1460-2075, 1460-2075
Online-Zugang:	Volltext
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Abstract	DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error‐free, and the third slow and error‐prone. A single gene, REV3L , encoding the catalytic subunit of DNA polymerase ζ (polζ), was found to have a pivotal role in TLS, being involved in TLS across all lesions examined, except for a TT cyclobutane dimer. Genetic epistasis siRNA analysis indicated that discrete two‐polymerase combinations with polζ dictate error‐prone or error‐free TLS across the same lesion. These results highlight the central role of polζ in both error‐prone and error‐free TLS in mammalian cells, and show that bypass of a single lesion may involve at least three different DNA polymerases, operating in different two‐polymerase combinations.
AbstractList	DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error‐free, and the third slow and error‐prone. A single gene, REV3L , encoding the catalytic subunit of DNA polymerase ζ (polζ), was found to have a pivotal role in TLS, being involved in TLS across all lesions examined, except for a TT cyclobutane dimer. Genetic epistasis siRNA analysis indicated that discrete two‐polymerase combinations with polζ dictate error‐prone or error‐free TLS across the same lesion. These results highlight the central role of polζ in both error‐prone and error‐free TLS in mammalian cells, and show that bypass of a single lesion may involve at least three different DNA polymerases, operating in different two‐polymerase combinations. DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error-free, and the third slow and error-prone. A single gene, REV3L, encoding the catalytic subunit of DNA polymerase zeta (pol zeta), was found to have a pivotal role in TLS, being involved in TLS across all lesions examined, except for a TT cyclobutane dimer. Genetic epistasis siRNA analysis indicated that discrete two-polymerase combinations with pol zeta dictate error-prone or error-free TLS across the same lesion. These results highlight the central role of pol zeta in both error-prone and error-free TLS in mammalian cells, and show that bypass of a single lesion may involve at least three different DNA polymerases, operating in different two-polymerase combinations. DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error-free, and the third slow and error-prone. A single gene, REV3L, encoding the catalytic subunit of DNA polymerase zeta (polzeta), was found to have a pivotal role in TLS, being involved in TLS across all lesions examined, except for a TT cyclobutane dimer. Genetic epistasis siRNA analysis indicated that discrete two-polymerase combinations with polzeta dictate error-prone or error-free TLS across the same lesion. These results highlight the central role of polzeta in both error-prone and error-free TLS in mammalian cells, and show that bypass of a single lesion may involve at least three different DNA polymerases, operating in different two-polymerase combinations. [PUBLICATION ABSTRACT] DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error-free, and the third slow and error-prone. A single gene, REV3L, encoding the catalytic subunit of DNA polymerase ζ (polζ), was found to have a pivotal role in TLS, being involved in TLS across all lesions examined, except for a TT cyclobutane dimer. Genetic epistasis siRNA analysis indicated that discrete two-polymerase combinations with polζ dictate error-prone or error-free TLS across the same lesion. These results highlight the central role of polζ in both error-prone and error-free TLS in mammalian cells, and show that bypass of a single lesion may involve at least three different DNA polymerases, operating in different two-polymerase combinations. DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error-free, and the third slow and error-prone. A single gene, REV3L, encoding the catalytic subunit of DNA polymerase zeta (pol zeta), was found to have a pivotal role in TLS, being involved in TLS across all lesions examined, except for a TT cyclobutane dimer. Genetic epistasis siRNA analysis indicated that discrete two-polymerase combinations with pol zeta dictate error-prone or error-free TLS across the same lesion. These results highlight the central role of pol zeta in both error-prone and error-free TLS in mammalian cells, and show that bypass of a single lesion may involve at least three different DNA polymerases, operating in different two-polymerase combinations.DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error-free, and the third slow and error-prone. A single gene, REV3L, encoding the catalytic subunit of DNA polymerase zeta (pol zeta), was found to have a pivotal role in TLS, being involved in TLS across all lesions examined, except for a TT cyclobutane dimer. Genetic epistasis siRNA analysis indicated that discrete two-polymerase combinations with pol zeta dictate error-prone or error-free TLS across the same lesion. These results highlight the central role of pol zeta in both error-prone and error-free TLS in mammalian cells, and show that bypass of a single lesion may involve at least three different DNA polymerases, operating in different two-polymerase combinations.
Author	Ziv, Omer Friedberg, Errol C Wang, Zhigang Reißner, Thomas Adar, Sheera Carell, Thomas Shachar, Sigal Livneh, Zvi Geacintov, Nicholas Avkin, Sharon Wittschieben, John Chaney, Stephen
Author_xml	– sequence: 1 givenname: Sigal surname: Shachar fullname: Shachar, Sigal organization: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel – sequence: 2 givenname: Omer surname: Ziv fullname: Ziv, Omer organization: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel – sequence: 3 givenname: Sharon surname: Avkin fullname: Avkin, Sharon organization: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel – sequence: 4 givenname: Sheera surname: Adar fullname: Adar, Sheera organization: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel – sequence: 5 givenname: John surname: Wittschieben fullname: Wittschieben, John organization: Department of Pharmacology, University of Pittsburgh Medical School and University of Pittsburgh Cancer Institute, PA, Pittsburgh, USA – sequence: 6 givenname: Thomas surname: Reißner fullname: Reißner, Thomas organization: Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, München, Germany – sequence: 7 givenname: Stephen surname: Chaney fullname: Chaney, Stephen organization: Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, NC, Chapel Hill, USA – sequence: 8 givenname: Errol C surname: Friedberg fullname: Friedberg, Errol C organization: Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, TX, Dallas, USA – sequence: 9 givenname: Zhigang surname: Wang fullname: Wang, Zhigang organization: Graduate Center for Toxicology, University of Kentucky, KY, Lexington, USA – sequence: 10 givenname: Thomas surname: Carell fullname: Carell, Thomas organization: Department of Chemistry and Biochemistry, Ludwig-Maximilians-University Munich, München, Germany – sequence: 11 givenname: Nicholas surname: Geacintov fullname: Geacintov, Nicholas organization: Chemistry Department, New York University, NY, New York, USA – sequence: 12 givenname: Zvi surname: Livneh fullname: Livneh, Zvi email: zvi.livneh@weizmann.ac.il organization: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/19153606$$D View this record in MEDLINE/PubMed
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Snippet	DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect...
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SubjectTerms	Animals carcinogenesis Catalysis Cell Line, Tumor Cellular biology Deoxyribonucleic acid Dimerization DNA DNA - chemistry DNA - metabolism DNA Damage DNA polymerase DNA repair DNA Replication DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - metabolism Epistasis, Genetic Genomics Humans Kinetics lesion bypass Lesions Mammals Mice Molecular biology Mutagenesis Pyrimidine Dimers - chemistry RNA, Small Interfering - metabolism Xeroderma Pigmentosum Group A Protein - metabolism
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Title	Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
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