Microbiological profile and risk factors for in-hospital mortality of infective endocarditis in tertiary care hospitals of south Vietnam

We aimed to evaluate the microbiological characteristics and risk factors for mortality of infective endocarditis in two tertiary hospitals in Ho Chi Minh City, south Vietnam. A retrospective study of 189 patients (120 men, 69 women; mean age 38 ± 18 years) with the diagnosis of probable or definite...

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Vydané v:PloS one Ročník 12; číslo 12; s. e0189421
Hlavní autori: Tran, Hoang M., Truong, Vien T., Ngo, Tam M. N., Bui, Quoc P. V., Nguyen, Hoang C., Le, Trung T. Q., Mazur, Wojciech, Chung, Eugene, Cafardi, John M., Pham, Khanh P. N., Duong, Hoang H. N., Nguyen, Thach, Nguyen, Vu T., Pham, Vinh N.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Public Library of Science 14.12.2017
Public Library of Science (PLoS)
Predmet:
Ampicillin
Analysis
Antibiotics
Antimicrobial resistance
Biology and Life Sciences
Blood
Cardiology
Ceftriaxone
Congenital diseases
Endocarditis
Epidemiology
Health risk assessment
Health risks
Heart
Heart diseases
Heart failure
Hospitals
Infectious diseases
Infective endocarditis
Medicine
Medicine and Health Sciences
Methicillin
Mortality
Oral hygiene
Pathogens
Patients
Penicillin
Prostheses
Quality
Regression analysis
Risk analysis
Risk factors
Sensitivity
Slopes
Staphylococcus aureus
Statistical analysis
Vancomycin
Vegetation
Vietnam
Vietnam
United States > US
Ohio
ISSN:1932-6203, 1932-6203
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Popis
Shrnutí:We aimed to evaluate the microbiological characteristics and risk factors for mortality of infective endocarditis in two tertiary hospitals in Ho Chi Minh City, south Vietnam. A retrospective study of 189 patients (120 men, 69 women; mean age 38 ± 18 years) with the diagnosis of probable or definite infective endocarditis (IE) according to the modified Duke Criteria admitted to The Heart Institute or Tam Duc Hospital between January 2005 and December 2014. IE was related to a native valve in 165 patients (87.3%), and prosthetic valve in 24 (12.7%). Of the 189 patients in our series, the culture positive rate was 70.4%. The most common isolated pathogens were Streptococci (75.2%), Staphylococci (9.8%) followed by gram negative organism (4.5%). The sensitivity rate of Streptococci to ampicillin, ceftriaxone or vancomycin was 100%. The rate of methicillin resistant Staphylococcus aureus was 40%. There was a decrease in penicillin sensitivity for Streptococci over three eras: 2005-2007 (100%), 2008-2010 (94%) and 2010-2014 (84%). The in-hospital mortality rate was 6.9%. Logistic regression analysis found prosthetic valve and NYHA grade 3 or 4 heart failure and vegetation size of more than 15 mm as strong predictors of in-hospital mortality. Streptococcal species were the major pathogen of IE in the recent years with low rates of antimicrobial resistance. Prosthetic valve involvement, moderate or severe heart failure and vegetation size of more than 15 mm were independent predictors for in-hospital mortality in IE.
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0189421