Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease

Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from drug target failure, we compared evidence from clinical trials and drug target Mendelian randomization of CETP protein concentratio...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 5640 - 10
Main Authors:	Schmidt, Amand F., Hunt, Nicholas B., Gordillo-Marañón, Maria, Charoen, Pimphen, Drenos, Fotios, Kivimaki, Mika, Lawlor, Deborah A., Giambartolomei, Claudia, Papacosta, Olia, Chaturvedi, Nishi, Bis, Joshua C., O’Donnell, Christopher J., Wannamethee, Goya, Wong, Andrew, Price, Jackie F., Hughes, Alun D., Gaunt, Tom R., Franceschini, Nora, Mook-Kanamori, Dennis O., Zwierzyna, Magdalena, Sofat, Reecha, Hingorani, Aroon D., Finan, Chris
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24.09.2021 Nature Publishing Group Nature Portfolio
Subjects:	140/131 45/43 631/154/556 692/308/2779 692/699/75 Age Age related diseases Alzheimer's disease Amides - therapeutic use Anticholesteremic Agents - therapeutic use Asthma Benzodiazepines - therapeutic use Blood pressure Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - metabolism Cardiovascular Diseases - prevention & control Cholesterol Ester Transfer Proteins - antagonists & inhibitors Cholesterol Ester Transfer Proteins - genetics Cholesterol Ester Transfer Proteins - metabolism Cholesteryl ester transfer protein Clinical trials Congestive heart failure Coronary artery disease Coronary Disease - metabolism Coronary Disease - prevention & control Diabetes mellitus Esters - therapeutic use Eye diseases Fibrillation Heart diseases Heart failure Heterogeneity Humanities and Social Sciences Humans Inhibitors Kexin Kidney diseases Kidneys Lipids Macular degeneration Mendelian Randomization Analysis Metabolites multidisciplinary Multiple sclerosis Neurodegenerative diseases Oxazolidinones - therapeutic use Pressure effects Proprotein convertases Proteins Quinolines - therapeutic use Randomization Renal failure Risk Science Science (multidisciplinary) Subtilisin Sulfhydryl Compounds - therapeutic use Therapeutic targets
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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