Generation of human islet cell type-specific identity genesets

Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity. Here, we conduct a thorough single-cell transcriptomics m...

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Veröffentlicht in:	Nature communications Jg. 13; H. 1; S. 2020 - 14
Hauptverfasser:	van Gurp, Léon, Fodoulian, Leon, Oropeza, Daniel, Furuyama, Kenichiro, Bru-Tari, Eva, Vu, Anh Nguyet, Kaddis, John S., Rodríguez, Iván, Thorel, Fabrizio, Herrera, Pedro L.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 19.04.2022 Nature Publishing Group Nature Portfolio
Schlagworte:	13/106 13/31 38 38/32 38/91 631/337/2019 692/53/2423 692/699/2743/137 Beta cells Cell differentiation Cell Differentiation - genetics Cell therapy Diabetes Diabetes mellitus Differentiation (biology) Embryogenesis Humanities and Social Sciences Humans Insulin Insulin - genetics Insulin-Secreting Cells Islets of Langerhans Meta-analysis multidisciplinary Pluripotency Pluripotent Stem Cells Science Science (multidisciplinary) Stem cells Transcriptomics
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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