OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

Rewiring of energy metabolism and adaptation of mitochondria are considered to impact on prostate cancer development and progression. Here, we report on mitochondrial respiration, DNA mutations and gene expression in paired benign/malignant human prostate tissue samples. Results reveal reduced respi...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 1487 - 16
Main Authors:	Schöpf, Bernd, Weissensteiner, Hansi, Schäfer, Georg, Fazzini, Federica, Charoentong, Pornpimol, Naschberger, Andreas, Rupp, Bernhard, Fendt, Liane, Bukur, Valesca, Giese, Irina, Sorn, Patrick, Sant’Anna-Silva, Ana Carolina, Iglesias-Gonzalez, Javier, Sahin, Ugur, Kronenberg, Florian, Gnaiger, Erich, Klocker, Helmut
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.03.2020 Nature Publishing Group Nature Portfolio
Subjects:	38/39 45/22 45/23 45/90 45/91 49 631/208/514/2254 631/45/320 631/67/589/466 82/1 82/51 82/80 Amino acids Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Electron transport chain Electron Transport Complex I - metabolism Energy Metabolism Gene expression High-Throughput Nucleotide Sequencing Humanities and Social Sciences Humans Malate Malates Male Metabolism Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA multidisciplinary Mutation NADH NADH-ubiquinone oxidoreductase Nicotinamide adenine dinucleotide Oxidation Oxidation-Reduction Oxidative Phosphorylation Phenotypes Prostate - metabolism Prostate - pathology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Respiration Risk analysis Risk factors Science Science (multidisciplinary) Substrates Succinic Acid - metabolism Transcriptome Tumors Wiring
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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