High grade serous ovarian carcinomas originate in the fallopian tube

High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy n...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature communications Jg. 8; H. 1; S. 1093 - 11
Hauptverfasser:	Labidi-Galy, S. Intidhar, Papp, Eniko, Hallberg, Dorothy, Niknafs, Noushin, Adleff, Vilmos, Noe, Michael, Bhattacharya, Rohit, Novak, Marian, Jones, Siân, Phallen, Jillian, Hruban, Carolyn A., Hirsch, Michelle S., Lin, Douglas I., Schwartz, Lauren, Maire, Cecile L., Tille, Jean-Christophe, Bowden, Michaela, Ayhan, Ayse, Wood, Laura D., Scharpf, Robert B., Kurman, Robert, Wang, Tian-Li, Shih, Ie-Ming, Karchin, Rachel, Drapkin, Ronny, Velculescu, Victor E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 23.10.2017 Nature Publishing Group Nature Portfolio
Schlagworte:	631/67/1517/1709 631/67/69 Aberration Alleles BRCA1 protein BRCA2 protein Breast cancer Cancer Copy number Cystadenocarcinoma, Serous - genetics DNA Copy Number Variations - genetics Etiology Evolution Fallopian tube Fallopian Tube Neoplasms - metabolism Fallopian Tube Neoplasms - pathology Fallopian Tubes - metabolism Fallopian Tubes - pathology Female Genital cancers Gynecological cancer Humanities and Social Sciences Humans Immunohistochemistry Laser Capture Microdissection Lesions Metastases Metastasis multidisciplinary Neoplasms, Cystic, Mucinous, and Serous - metabolism Neoplasms, Cystic, Mucinous, and Serous - pathology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics p53 Protein Patients PTEN protein Science Science (multidisciplinary) Signatures
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients. The majority of tumor-specific alterations in ovarian cancers were present in STICs, including those affecting TP53, BRCA1 , BRCA2 or PTEN . Evolutionary analyses reveal that p53 signatures and STICs are precursors of ovarian carcinoma and identify a window of 7 years between development of a STIC and initiation of ovarian carcinoma, with metastases following rapidly thereafter. Our results provide insights into the etiology of ovarian cancer and have implications for prevention, early detection and therapeutic intervention of this disease. It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients and establish the evolutionary origins of HGSOC in the fallopian tube.
AbstractList	High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients. The majority of tumor-specific alterations in ovarian cancers were present in STICs, including those affecting TP53, BRCA1, BRCA2 or PTEN. Evolutionary analyses reveal that p53 signatures and STICs are precursors of ovarian carcinoma and identify a window of 7 years between development of a STIC and initiation of ovarian carcinoma, with metastases following rapidly thereafter. Our results provide insights into the etiology of ovarian cancer and have implications for prevention, early detection and therapeutic intervention of this disease.High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients. The majority of tumor-specific alterations in ovarian cancers were present in STICs, including those affecting TP53, BRCA1, BRCA2 or PTEN. Evolutionary analyses reveal that p53 signatures and STICs are precursors of ovarian carcinoma and identify a window of 7 years between development of a STIC and initiation of ovarian carcinoma, with metastases following rapidly thereafter. Our results provide insights into the etiology of ovarian cancer and have implications for prevention, early detection and therapeutic intervention of this disease. High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients. The majority of tumor-specific alterations in ovarian cancers were present in STICs, including those affecting TP53, BRCA1 , BRCA2 or PTEN . Evolutionary analyses reveal that p53 signatures and STICs are precursors of ovarian carcinoma and identify a window of 7 years between development of a STIC and initiation of ovarian carcinoma, with metastases following rapidly thereafter. Our results provide insights into the etiology of ovarian cancer and have implications for prevention, early detection and therapeutic intervention of this disease. High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients. The majority of tumor-specific alterations in ovarian cancers were present in STICs, including those affecting TP53, BRCA1, BRCA2 or PTEN. Evolutionary analyses reveal that p53 signatures and STICs are precursors of ovarian carcinoma and identify a window of 7 years between development of a STIC and initiation of ovarian carcinoma, with metastases following rapidly thereafter. Our results provide insights into the etiology of ovarian cancer and have implications for prevention, early detection and therapeutic intervention of this disease. It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients and establish the evolutionary origins of HGSOC in the fallopian tube. High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients. The majority of tumor-specific alterations in ovarian cancers were present in STICs, including those affecting TP53, BRCA1 , BRCA2 or PTEN . Evolutionary analyses reveal that p53 signatures and STICs are precursors of ovarian carcinoma and identify a window of 7 years between development of a STIC and initiation of ovarian carcinoma, with metastases following rapidly thereafter. Our results provide insights into the etiology of ovarian cancer and have implications for prevention, early detection and therapeutic intervention of this disease. It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients and establish the evolutionary origins of HGSOC in the fallopian tube. High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. Here, we perform whole-exome sequence and copy number analyses of laser capture microdissected fallopian tube lesions (p53 signatures, serous tubal intraepithelial carcinomas (STICs), and fallopian tube carcinomas), ovarian cancers, and metastases from nine patients. The majority of tumor-specific alterations in ovarian cancers were present in STICs, including those affecting TP53, BRCA1, BRCA2 or PTEN. Evolutionary analyses reveal that p53 signatures and STICs are precursors of ovarian carcinoma and identify a window of 7 years between development of a STIC and initiation of ovarian carcinoma, with metastases following rapidly thereafter. Our results provide insights into the etiology of ovarian cancer and have implications for prevention, early detection and therapeutic intervention of this disease. It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers, and metastases from HGSOC patients and establish the evolutionary origins of HGSOC in the fallopian tube.
ArticleNumber	1093
Author	Adleff, Vilmos Wang, Tian-Li Labidi-Galy, S. Intidhar Kurman, Robert Shih, Ie-Ming Ayhan, Ayse Papp, Eniko Noe, Michael Jones, Siân Wood, Laura D. Tille, Jean-Christophe Maire, Cecile L. Novak, Marian Bowden, Michaela Drapkin, Ronny Bhattacharya, Rohit Hirsch, Michelle S. Hruban, Carolyn A. Schwartz, Lauren Karchin, Rachel Velculescu, Victor E. Scharpf, Robert B. Niknafs, Noushin Phallen, Jillian Hallberg, Dorothy Lin, Douglas I.
Author_xml	– sequence: 1 givenname: S. Intidhar surname: Labidi-Galy fullname: Labidi-Galy, S. Intidhar organization: Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Department of Oncology, Geneva University Hospitals – sequence: 2 givenname: Eniko surname: Papp fullname: Papp, Eniko organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Personal Genome Diagnostics – sequence: 3 givenname: Dorothy surname: Hallberg fullname: Hallberg, Dorothy organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine – sequence: 4 givenname: Noushin surname: Niknafs fullname: Niknafs, Noushin organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University – sequence: 5 givenname: Vilmos surname: Adleff fullname: Adleff, Vilmos organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine – sequence: 6 givenname: Michael surname: Noe fullname: Noe, Michael organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine – sequence: 7 givenname: Rohit surname: Bhattacharya fullname: Bhattacharya, Rohit organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Department of Computer Science, Institute for Computational Medicine, Johns Hopkins University – sequence: 8 givenname: Marian surname: Novak fullname: Novak, Marian organization: Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Personal Genome Diagnostics – sequence: 9 givenname: Siân surname: Jones fullname: Jones, Siân organization: Personal Genome Diagnostics – sequence: 10 givenname: Jillian surname: Phallen fullname: Phallen, Jillian organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine – sequence: 11 givenname: Carolyn A. surname: Hruban fullname: Hruban, Carolyn A. organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine – sequence: 12 givenname: Michelle S. surname: Hirsch fullname: Hirsch, Michelle S. organization: Department of Pathology, Brigham and Women’s hospital and Harvard Medical School – sequence: 13 givenname: Douglas I. surname: Lin fullname: Lin, Douglas I. organization: Department of Pathology, Brigham and Women’s hospital and Harvard Medical School, Department of Pathology, Beth Israel Deaconess Medical Center – sequence: 14 givenname: Lauren surname: Schwartz fullname: Schwartz, Lauren organization: Department of Pathology, University of Pennsylvania Perelman School of Medicine – sequence: 15 givenname: Cecile L. surname: Maire fullname: Maire, Cecile L. organization: Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School – sequence: 16 givenname: Jean-Christophe surname: Tille fullname: Tille, Jean-Christophe organization: Division of Clinical Pathology, Faculty of Medicine, Geneva University Hospital – sequence: 17 givenname: Michaela surname: Bowden fullname: Bowden, Michaela organization: Department of Pathology, Brigham and Women’s hospital and Harvard Medical School – sequence: 18 givenname: Ayse orcidid: 0000-0003-0136-4271 surname: Ayhan fullname: Ayhan, Ayse organization: Department of Pathology, Seirei Mikatahara Hospital, Department of Tumor Pathology, Hamamatsu University School of Medicine, Department of Molecular Pathology, Hiroshima University School of Medicine, Departments of Gynecology and Obstetrics and Pathology, Johns Hopkins University School of Medicine – sequence: 19 givenname: Laura D. surname: Wood fullname: Wood, Laura D. organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine – sequence: 20 givenname: Robert B. surname: Scharpf fullname: Scharpf, Robert B. organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine – sequence: 21 givenname: Robert surname: Kurman fullname: Kurman, Robert organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Departments of Gynecology and Obstetrics and Pathology, Johns Hopkins University School of Medicine – sequence: 22 givenname: Tian-Li surname: Wang fullname: Wang, Tian-Li organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Departments of Gynecology and Obstetrics and Pathology, Johns Hopkins University School of Medicine – sequence: 23 givenname: Ie-Ming surname: Shih fullname: Shih, Ie-Ming organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Departments of Gynecology and Obstetrics and Pathology, Johns Hopkins University School of Medicine – sequence: 24 givenname: Rachel surname: Karchin fullname: Karchin, Rachel organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University – sequence: 25 givenname: Ronny orcidid: 0000-0002-6912-6977 surname: Drapkin fullname: Drapkin, Ronny email: rdrapkin@pennmedicine.upenn.edu organization: Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Department of Pathology, Brigham and Women’s hospital and Harvard Medical School, Department of Obstetrics and Gynecology, Penn Ovarian Cancer Research Center, University of Pennsylvania Perelman School of Medicine – sequence: 26 givenname: Victor E. orcidid: 0000-0003-1195-438X surname: Velculescu fullname: Velculescu, Victor E. email: velculescu@jhmi.edu organization: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29061967$$D View this record in MEDLINE/PubMed
BookMark	eNp9kl1rFTEQhoNUbK39A17IgjferOZr83EjSP1ooeCNXodJNrsnhz3JMdlT8N-b7bZyWtBAmGTyzsPLZF6ik5iiR-g1we8JZupD4YQL2WJSN9aCtuQZOqOYk5ZIyk6OzqfoopQtrotpojh_gU6pxoJoIc_Q56swbpoxQ--b4nM6lCbdQg4QGwfZhZh2UFM5jCHC7JsQm3njmwGmKe0X1Xyw_hV6XhPFX9zHc_Tz65cfl1ftzfdv15efblonsJjbgcuBDhT3CijvJHhiudbWatJLT7knylk1dPWiJFVUSusIAO0Fc1yJGs7R9crtE2zNPocd5N8mQTB3iZRHA3kObvJGMqYYg044YXlHiHZedcLCwCrY9rqyPq6s_cHufO98nDNMj6CPX2LYmDHdmk50TAhVAe_uATn9Ovgym10ozk8TRF_baIjuOiwYpovvt0-k23TIsbZqUXGmhGakqt4cO_pr5eGzqkCtApdTKdkPxoUZ5pAWg2EyBJtlNMw6GqaOhrkbDbOw6ZPSB_p_i9haVKo4jj4f2f531R-fRcoX
CitedBy_id	crossref_primary_10_1016_j_modpat_2024_100629 crossref_primary_10_1038_s41598_021_93992_1 crossref_primary_10_1158_1078_0432_CCR_23_0932 crossref_primary_10_1001_jamasurg_2025_2818 crossref_primary_10_1038_s41416_025_03082_6 crossref_primary_10_1002_ijc_32916 crossref_primary_10_26641_2307_0404_2020_1_200405 crossref_primary_10_1016_j_humpath_2019_06_001 crossref_primary_10_1002_path_5161 crossref_primary_10_1111_boc_201800072 crossref_primary_10_1016_j_ygyno_2018_11_016 crossref_primary_10_3390_ijms241511890 crossref_primary_10_3390_cancers11101458 crossref_primary_10_1016_j_ygyno_2024_07_690 crossref_primary_10_3390_ijms25020886 crossref_primary_10_1371_journal_pgen_1008808 crossref_primary_10_1210_endocr_bqab078 crossref_primary_10_1007_s10585_021_10136_5 crossref_primary_10_1016_j_cobme_2022_100384 crossref_primary_10_1038_s41467_024_47271_y crossref_primary_10_1111_aji_13284 crossref_primary_10_3390_cancers11060838 crossref_primary_10_1038_s41388_025_03382_4 crossref_primary_10_25259_CytoJournal_7_2020 crossref_primary_10_3390_medicines5010016 crossref_primary_10_3390_cancers13030468 crossref_primary_10_1111_his_14722 crossref_primary_10_1038_s41568_021_00389_3 crossref_primary_10_1002_cncr_32004 crossref_primary_10_1016_j_ebiom_2024_105554 crossref_primary_10_1038_s41467_020_15089_z crossref_primary_10_3390_cancers13133349 crossref_primary_10_3390_ijerph19169896 crossref_primary_10_1007_s00520_021_06726_4 crossref_primary_10_1016_j_ygyno_2020_09_041 crossref_primary_10_1007_s00761_018_0495_8 crossref_primary_10_1097_PGP_0000000000000590 crossref_primary_10_1242_dmm_049001 crossref_primary_10_1111_his_14609 crossref_primary_10_1016_j_cancergen_2019_11_008 crossref_primary_10_1002_path_5065 crossref_primary_10_7554_eLife_60481 crossref_primary_10_1007_s10439_019_02402_1 crossref_primary_10_1002_14651858_CD012007_pub2 crossref_primary_10_3390_cancers10120468 crossref_primary_10_1038_s41419_020_2356_9 crossref_primary_10_1016_j_ygyno_2020_04_707 crossref_primary_10_1038_s41586_019_1173_8 crossref_primary_10_1080_14789450_2019_1666004 crossref_primary_10_3389_fimmu_2025_1556377 crossref_primary_10_1007_s43032_022_01049_z crossref_primary_10_1016_j_matbio_2023_02_004 crossref_primary_10_3389_fonc_2022_837233 crossref_primary_10_1016_j_surg_2018_03_024 crossref_primary_10_1126_scitranslmed_aaq1227 crossref_primary_10_1186_s13072_021_00401_y crossref_primary_10_1016_j_omton_2025_201023 crossref_primary_10_1038_s41388_023_02679_6 crossref_primary_10_3390_ijms241210154 crossref_primary_10_3389_fonc_2022_951292 crossref_primary_10_1016_j_maturitas_2022_08_002 crossref_primary_10_1007_s10689_020_00166_5 crossref_primary_10_1111_cpr_13029 crossref_primary_10_1158_0008_5472_CAN_22_1620 crossref_primary_10_3390_cells14020133 crossref_primary_10_1007_s00109_020_02028_0 crossref_primary_10_1016_j_pharmthera_2020_107722 crossref_primary_10_1007_s13402_020_00554_0 crossref_primary_10_1016_j_semcancer_2020_08_005 crossref_primary_10_1016_j_semcancer_2021_12_007 crossref_primary_10_3390_cancers10110433 crossref_primary_10_1016_j_path_2019_01_007 crossref_primary_10_1016_j_ygyno_2018_10_002 crossref_primary_10_1016_j_ejro_2019_04_001 crossref_primary_10_1080_01443615_2023_2283162 crossref_primary_10_3390_genes16050556 crossref_primary_10_1016_j_jogc_2022_08_018 crossref_primary_10_1136_ijgc_2022_003911 crossref_primary_10_1186_s13063_018_3083_8 crossref_primary_10_1126_sciadv_ads5002 crossref_primary_10_1158_1541_7786_MCR_19_0530 crossref_primary_10_3390_healthcare11010008 crossref_primary_10_1016_j_jbc_2024_107897 crossref_primary_10_3389_fphar_2018_00842 crossref_primary_10_1038_d41586_021_03717_7 crossref_primary_10_1177_17588359221148024 crossref_primary_10_1038_s43856_022_00193_6 crossref_primary_10_6061_clinics_2019_e1343 crossref_primary_10_1093_jnci_djae348 crossref_primary_10_1097_SLA_0000000000005374 crossref_primary_10_1007_s00404_020_05445_1 crossref_primary_10_1016_j_cell_2022_02_012 crossref_primary_10_1038_s41698_018_0063_0 crossref_primary_10_1111_aogs_15091 crossref_primary_10_1038_s10038_021_00940_y crossref_primary_10_1016_j_canlet_2020_11_011 crossref_primary_10_3390_cancers17183041 crossref_primary_10_3389_fonc_2019_01549 crossref_primary_10_1136_ijgc_2018_000016 crossref_primary_10_1038_s41416_022_02067_z crossref_primary_10_1186_s13048_023_01196_0 crossref_primary_10_20935_AcadOnco7620 crossref_primary_10_3390_cancers12123733 crossref_primary_10_1016_j_ygyno_2018_11_033 crossref_primary_10_3389_fonc_2020_523989 crossref_primary_10_1016_j_ctrv_2018_06_004 crossref_primary_10_1016_j_ijbiomac_2018_06_036 crossref_primary_10_3390_ijms22020867 crossref_primary_10_1097_PGP_0000000000001018 crossref_primary_10_3390_cells8121554 crossref_primary_10_1016_j_mce_2021_111367 crossref_primary_10_1038_s41467_019_13116_2 crossref_primary_10_1371_journal_pcbi_1009085 crossref_primary_10_3390_cancers13051085 crossref_primary_10_1136_ijgc_2019_000308 crossref_primary_10_1186_s13048_024_01522_0 crossref_primary_10_1016_j_ijbiomac_2025_144259 crossref_primary_10_3390_cancers11010119 crossref_primary_10_1007_s00404_023_06919_8 crossref_primary_10_1016_j_neo_2021_12_008 crossref_primary_10_12688_f1000research_20608_1 crossref_primary_10_1016_j_ygyno_2021_10_072 crossref_primary_10_1002_ijc_32999 crossref_primary_10_1016_j_xcrm_2025_102316 crossref_primary_10_1016_j_ygyno_2018_08_005 crossref_primary_10_3390_ijms21186467 crossref_primary_10_1016_j_molmet_2025_102225 crossref_primary_10_3390_ph16091210 crossref_primary_10_1016_j_ajog_2020_04_028 crossref_primary_10_1097_PGP_0000000000000534 crossref_primary_10_1002_ijc_32990 crossref_primary_10_1007_s12013_019_00888_z crossref_primary_10_1186_s13073_021_00998_5 crossref_primary_10_1097_PAS_0000000000001283 crossref_primary_10_1016_j_ejso_2025_110469 crossref_primary_10_1016_j_ygyno_2022_03_030 crossref_primary_10_1016_j_canlet_2020_02_017 crossref_primary_10_3389_fcell_2021_807862 crossref_primary_10_1124_jpet_124_002298 crossref_primary_10_3390_ijms251810195 crossref_primary_10_3390_cells11030539 crossref_primary_10_1016_j_tranon_2020_100930 crossref_primary_10_3390_ijms20215322 crossref_primary_10_1186_s13244_020_00895_2 crossref_primary_10_1097_PGP_0000000000000668 crossref_primary_10_1177_15330338211027917 crossref_primary_10_3390_cells11233835 crossref_primary_10_1016_j_bpobgyn_2018_01_017 crossref_primary_10_1016_j_isci_2024_108990 crossref_primary_10_1016_j_jbc_2024_107686 crossref_primary_10_3390_sym14071403 crossref_primary_10_1038_s41416_020_0900_0 crossref_primary_10_1038_s41598_023_28840_5 crossref_primary_10_1093_jnci_djae300 crossref_primary_10_1002_1878_0261_70067 crossref_primary_10_1038_s41598_024_60975_x crossref_primary_10_1200_EDBK_433576 crossref_primary_10_1016_j_canlet_2020_11_051 crossref_primary_10_1016_j_canep_2022_102253 crossref_primary_10_1016_j_jsbmb_2019_105498 crossref_primary_10_3892_ol_2022_13308 crossref_primary_10_3322_caac_21559 crossref_primary_10_1038_s41388_022_02224_x crossref_primary_10_1210_endrev_bnad018 crossref_primary_10_1002_1878_0261_12811 crossref_primary_10_36290_xon_2024_061 crossref_primary_10_3390_ijerph191912057 crossref_primary_10_1001_jamanetworkopen_2020_7566 crossref_primary_10_1093_infdis_jiab017 crossref_primary_10_1158_0008_5472_CAN_20_1518 crossref_primary_10_1016_j_ijgc_2025_101635 crossref_primary_10_1093_jncics_pkae027 crossref_primary_10_1097_PAS_0000000000002229 crossref_primary_10_3389_fimmu_2023_1288027 crossref_primary_10_1136_ijgc_2021_003153 crossref_primary_10_1002_ijgo_12845 crossref_primary_10_1158_2159_8290_CD_24_1326 crossref_primary_10_3390_diagnostics10020120 crossref_primary_10_1016_j_ejcsup_2020_02_001 crossref_primary_10_1038_s41467_022_34523_y crossref_primary_10_1210_clinem_dgab195 crossref_primary_10_1007_s11523_018_0606_x crossref_primary_10_3390_cancers10080262 crossref_primary_10_3390_cancers13153840 crossref_primary_10_3390_ijms22094409 crossref_primary_10_1038_s41525_024_00448_2 crossref_primary_10_1158_1078_0432_CCR_20_0270 crossref_primary_10_3389_fonc_2022_853755 crossref_primary_10_1016_j_heliyon_2025_e42539 crossref_primary_10_1111_aogs_15128 crossref_primary_10_3390_ijms232213777 crossref_primary_10_1016_j_canep_2024_102720 crossref_primary_10_1016_j_cell_2021_07_005 crossref_primary_10_1038_s41598_022_06796_2 crossref_primary_10_1007_s11523_018_0582_1 crossref_primary_10_3390_cells10020437 crossref_primary_10_1158_1078_0432_CCR_18_1199 crossref_primary_10_1016_j_tjog_2022_09_006 crossref_primary_10_1055_s_0041_1736211 crossref_primary_10_3390_cancers11111805 crossref_primary_10_1097_GRF_0000000000000521 crossref_primary_10_1002_jcp_31495 crossref_primary_10_1158_2159_8290_CD_24_0015 crossref_primary_10_3389_fonc_2025_1594100 crossref_primary_10_1002_ijc_34757 crossref_primary_10_1016_j_cellsig_2020_109539 crossref_primary_10_1186_s40246_025_00741_w crossref_primary_10_1002_cam4_2243 crossref_primary_10_1039_D0NR04488A crossref_primary_10_1097_PAP_0000000000000238 crossref_primary_10_3390_cancers11060884 crossref_primary_10_1002_cncy_22110 crossref_primary_10_1016_j_jsbmb_2024_106482 crossref_primary_10_3390_bioengineering10040423 crossref_primary_10_1038_s41389_018_0103_1 crossref_primary_10_1158_1078_0432_CCR_20_2782 crossref_primary_10_1038_s41379_020_00648_y crossref_primary_10_1002_ijc_33676 crossref_primary_10_1016_j_radcr_2024_06_052 crossref_primary_10_1016_j_humpath_2025_105762 crossref_primary_10_1186_s13000_019_0795_3 crossref_primary_10_1016_j_ccell_2023_04_017 crossref_primary_10_5694_mja2_52227 crossref_primary_10_1016_j_semcancer_2021_03_018 crossref_primary_10_1038_s41598_024_68249_2 crossref_primary_10_3389_fonc_2020_625866 crossref_primary_10_1111_aogs_14507 crossref_primary_10_1158_2159_8290_CD_24_1366 crossref_primary_10_1186_s12885_018_5250_4 crossref_primary_10_3390_cancers12051090 crossref_primary_10_1016_j_biopha_2021_111429 crossref_primary_10_1158_0008_5472_CAN_19_0852 crossref_primary_10_3389_fonc_2025_1546324 crossref_primary_10_1155_2022_2003739 crossref_primary_10_1158_2159_8290_CD_24_0393 crossref_primary_10_3390_cells10123491 crossref_primary_10_1016_j_ejca_2020_11_046 crossref_primary_10_1007_s00432_023_04697_z crossref_primary_10_3390_jcm12010296 crossref_primary_10_1002_advs_202301930 crossref_primary_10_3390_jpm12071074 crossref_primary_10_1038_s41416_021_01317_w crossref_primary_10_1016_j_celrep_2023_113354 crossref_primary_10_1038_s41598_020_65353_x crossref_primary_10_1111_1471_0528_18075 crossref_primary_10_1158_1078_0432_CCR_20_3331 crossref_primary_10_20935_AcadOnco7488 crossref_primary_10_3390_biomedicines10020199 crossref_primary_10_1038_s41598_018_35567_1 crossref_primary_10_1016_j_critrevonc_2024_104603 crossref_primary_10_1038_s41467_024_48286_1 crossref_primary_10_33549_physiolres_935029 crossref_primary_10_3390_ijms24119294 crossref_primary_10_1016_j_heliyon_2024_e27336 crossref_primary_10_1007_s10585_021_10077_z crossref_primary_10_3390_ijms26157512 crossref_primary_10_1038_s41586_023_06421_w crossref_primary_10_1158_1541_7786_MCR_22_0102 crossref_primary_10_1016_j_plipres_2024_101302 crossref_primary_10_1038_s41389_019_0154_y crossref_primary_10_1097_PSY_0000000000000747 crossref_primary_10_1038_s41467_020_17917_8 crossref_primary_10_1158_0008_5472_CAN_22_2217 crossref_primary_10_1002_ijc_34318 crossref_primary_10_1038_s41598_024_72814_0 crossref_primary_10_3390_cells8050505 crossref_primary_10_3390_cancers13092067 crossref_primary_10_33549_physiolres_935031 crossref_primary_10_1126_scitranslmed_ade1857 crossref_primary_10_1038_s41598_024_66324_2 crossref_primary_10_3390_ijms232214442 crossref_primary_10_1002_path_5752 crossref_primary_10_3389_fonc_2018_00654 crossref_primary_10_1038_s41417_022_00447_4 crossref_primary_10_1007_s00262_019_02454_1 crossref_primary_10_1097_PAS_0000000000002187 crossref_primary_10_7554_eLife_83867 crossref_primary_10_3390_biomedicines12010246 crossref_primary_10_3390_ijms23116211 crossref_primary_10_1186_s13048_020_00679_8 crossref_primary_10_1016_j_ajpath_2020_09_006 crossref_primary_10_1186_s13048_021_00825_w crossref_primary_10_3390_biomedicines10040824 crossref_primary_10_3390_cancers11081044 crossref_primary_10_1016_j_ijgc_2025_101667 crossref_primary_10_3390_genes14020277 crossref_primary_10_1038_s41598_019_54401_w crossref_primary_10_1038_s41467_024_55440_2 crossref_primary_10_1177_09636897231160216 crossref_primary_10_1186_s13073_020_00786_7 crossref_primary_10_1016_j_semcancer_2022_03_027 crossref_primary_10_1186_s12967_025_06508_0 crossref_primary_10_1186_s12916_022_02489_9 crossref_primary_10_1002_path_5891 crossref_primary_10_1073_pnas_2307802121 crossref_primary_10_1158_0008_5472_CAN_21_0536 crossref_primary_10_3390_genes12121917 crossref_primary_10_3390_nu16121816 crossref_primary_10_4069_kjwhn_2019_25_4_365 crossref_primary_10_3390_cells8050414 crossref_primary_10_1007_s13577_024_01048_z crossref_primary_10_1038_s44319_024_00233_3 crossref_primary_10_1007_s40471_020_00227_4 crossref_primary_10_1038_s41598_021_85342_y crossref_primary_10_1158_2159_8290_CD_24_0094 crossref_primary_10_1158_1541_7786_MCR_21_0565 crossref_primary_10_1038_s42003_025_07871_w crossref_primary_10_1002_ijgo_15386 crossref_primary_10_1136_jitc_2023_007099 crossref_primary_10_1158_0008_5472_CAN_17_1671 crossref_primary_10_1242_dmm_052177 crossref_primary_10_1016_j_modpat_2025_100890 crossref_primary_10_1038_s41598_019_51697_6 crossref_primary_10_1158_0008_5472_CAN_21_3819 crossref_primary_10_1007_s12195_019_00570_7 crossref_primary_10_1369_00221554211061359 crossref_primary_10_1186_s13045_020_00971_6 crossref_primary_10_1158_0008_5472_CAN_18_3029 crossref_primary_10_3390_ijms25137109 crossref_primary_10_1158_0008_5472_CAN_18_2297 crossref_primary_10_1093_annonc_mdz062 crossref_primary_10_1093_jnci_djx269 crossref_primary_10_1016_j_gore_2018_12_005 crossref_primary_10_1016_j_ccell_2020_01_003 crossref_primary_10_1038_s41467_025_58145_2 crossref_primary_10_1007_s00432_023_04578_5 crossref_primary_10_1097_PGP_0000000000000604 crossref_primary_10_1186_s13048_023_01124_2 crossref_primary_10_1016_j_ebiom_2022_104001 crossref_primary_10_1016_j_ygyno_2024_05_010 crossref_primary_10_1007_s10549_017_4605_x crossref_primary_10_1038_s41598_020_66556_y crossref_primary_10_3389_fonc_2020_524128 crossref_primary_10_1126_scitranslmed_adi2556 crossref_primary_10_3390_cancers13164029 crossref_primary_10_1016_j_pharmthera_2020_107524 crossref_primary_10_1007_s10689_024_00412_0 crossref_primary_10_1002_ijc_34496 crossref_primary_10_1038_s42003_022_04314_8 crossref_primary_10_1007_s10147_019_01536_5 crossref_primary_10_1007_s40944_024_00812_1 crossref_primary_10_1016_j_heliyon_2024_e38888 crossref_primary_10_1136_ijgc_2023_004377 crossref_primary_10_17116_patol20238501174 crossref_primary_10_3390_healthcare7030094 crossref_primary_10_3390_ijms22031422 crossref_primary_10_1002_path_5219 crossref_primary_10_1158_2767_9764_CRC_24_0400 crossref_primary_10_1158_0008_5472_CAN_19_1554 crossref_primary_10_1186_s13048_023_01234_x crossref_primary_10_3390_molecules26134077 crossref_primary_10_1055_a_2555_4602 crossref_primary_10_1158_2326_6066_CIR_19_0258 crossref_primary_10_3390_ijms19071930 crossref_primary_10_3390_cancers16203533 crossref_primary_10_1016_j_ajog_2022_04_036 crossref_primary_10_1016_j_gore_2025_101800 crossref_primary_10_1016_j_ajog_2023_06_043 crossref_primary_10_1111_jog_14944 crossref_primary_10_1016_j_ygyno_2019_03_003 crossref_primary_10_3390_ijms22105325 crossref_primary_10_1073_pnas_2023373118 crossref_primary_10_3390_cancers13143465 crossref_primary_10_1016_j_ajog_2018_10_016 crossref_primary_10_1002_cam4_2725 crossref_primary_10_3389_fonc_2020_561888 crossref_primary_10_1016_j_canlet_2024_217279 crossref_primary_10_1016_S1470_2045_23_00335_2 crossref_primary_10_1016_j_ajog_2023_03_045 crossref_primary_10_1016_S0140_6736_18_32552_2 crossref_primary_10_1038_s41419_023_06165_5 crossref_primary_10_1007_s00404_025_07974_z crossref_primary_10_1371_journal_pmed_1004639 crossref_primary_10_1093_carcin_bgy170 crossref_primary_10_1097_AOG_0000000000005781 crossref_primary_10_1016_j_crad_2019_07_019 crossref_primary_10_1371_journal_pmed_1004514 crossref_primary_10_1016_j_hoc_2018_07_013 crossref_primary_10_5812_ijcm_105436 crossref_primary_10_1038_s41598_023_44050_5 crossref_primary_10_3390_cancers13061352 crossref_primary_10_1016_j_ccell_2024_09_007 crossref_primary_10_1158_1078_0432_CCR_24_1583 crossref_primary_10_1007_s40291_024_00740_y crossref_primary_10_1093_humupd_dmac038 crossref_primary_10_1186_s12905_020_01065_8 crossref_primary_10_1002_path_6322 crossref_primary_10_1002_2056_4538_70037 crossref_primary_10_1016_j_jogoh_2020_101829 crossref_primary_10_3390_cancers12113462 crossref_primary_10_1111_his_14227 crossref_primary_10_1016_j_ajog_2025_06_024 crossref_primary_10_3389_fcell_2024_1449543 crossref_primary_10_1016_j_bbi_2023_08_006 crossref_primary_10_1007_s00404_024_07371_y crossref_primary_10_1038_s41418_025_01532_5 crossref_primary_10_1038_s41416_019_0422_9 crossref_primary_10_1158_2767_9764_CRC_25_0064 crossref_primary_10_1002_path_6218 crossref_primary_10_1038_s41568_022_00503_z crossref_primary_10_1155_2021_8875450 crossref_primary_10_1158_1541_7786_MCR_18_1233 crossref_primary_10_1158_1940_6207_CAPR_21_0121 crossref_primary_10_1001_jamanetworkopen_2025_32195 crossref_primary_10_1038_s41388_019_0842_2 crossref_primary_10_1016_j_trsl_2024_08_001 crossref_primary_10_1002_lsm_23877 crossref_primary_10_1158_2159_8290_CD_20_0455 crossref_primary_10_1097_01_JAA_0000000000000042 crossref_primary_10_1016_S1283_081X_25_50400_9 crossref_primary_10_3390_cancers15030868 crossref_primary_10_1016_j_maturitas_2022_01_006 crossref_primary_10_1148_rg_2021200086 crossref_primary_10_1016_j_isci_2023_106523 crossref_primary_10_1148_radiol_212737 crossref_primary_10_3390_cancers14051120 crossref_primary_10_1158_0008_5472_CAN_19_2567 crossref_primary_10_1016_j_ejca_2022_05_005 crossref_primary_10_1016_j_ygyno_2020_12_022 crossref_primary_10_1038_s41467_020_14551_2 crossref_primary_10_3389_fonc_2022_975703 crossref_primary_10_1016_j_ygyno_2021_07_008 crossref_primary_10_1186_s13048_023_01145_x crossref_primary_10_1158_1078_0432_CCR_21_1643 crossref_primary_10_3390_cancers15030757 crossref_primary_10_1111_aji_13649 crossref_primary_10_1016_j_canlet_2022_215779 crossref_primary_10_1109_ACCESS_2024_3460077 crossref_primary_10_2147_CMAR_S538281 crossref_primary_10_1002_path_5145 crossref_primary_10_1002_path_5266 crossref_primary_10_1016_j_gore_2019_01_010 crossref_primary_10_1172_JCI174013 crossref_primary_10_1001_jamanetworkopen_2021_47343 crossref_primary_10_1016_j_ejogrb_2018_03_043 crossref_primary_10_1016_j_gore_2025_101716 crossref_primary_10_1158_2159_8290_CD_24_0805 crossref_primary_10_1016_j_bbagen_2018_11_005 crossref_primary_10_1186_s13048_022_01002_3 crossref_primary_10_3389_fimmu_2024_1441730 crossref_primary_10_1038_s41417_023_00703_1 crossref_primary_10_1016_j_biopha_2020_110401 crossref_primary_10_3390_cancers12051250 crossref_primary_10_1200_PO_24_00589 crossref_primary_10_1016_j_genrep_2020_100821
Cites_doi	10.1002/path.1000 10.1038/nature14969 10.1371/journal.pcbi.1004416 10.1038/ng.3573 10.1097/AOG.0000000000000981 10.1093/bioinformatics/btp352 10.1200/JCO.2008.18.1107 10.1002/path.3023 10.1158/0008-5472.CAN-15-1382 10.1016/j.ygyno.2013.12.009 10.1006/gyno.2002.6779 10.1126/scitranslmed.aaa7161 10.1158/2159-8290.CD-16-0607 10.1001/jamaoncol.2015.1618 10.1016/j.ejca.2012.12.027 10.1016/j.ccr.2013.10.013 10.1038/nrc4019 10.1016/j.ajog.2014.01.003 10.1016/j.ygyno.2013.11.030 10.1097/01.AOG.0000187892.78392.3f 10.1097/01.pas.0000213335.40358.47 10.1093/biostatistics/kxh008 10.1016/j.ygyno.2016.11.039 10.1158/2159-8290.CD-13-1014 10.2353/jmoldx.2010.090200 10.1056/NEJMoa012158 10.1002/path.4230 10.1146/annurev-pathol-020712-163949 10.1073/pnas.0712345105 10.1097/PAS.0b013e3181cf3d79 10.1038/nature10166 10.1038/nature14410 10.1016/S0090-8258(03)00365-2 10.1038/modpathol.2010.119 10.1056/NEJMoa020119 10.3322/caac.21254 10.1097/AOG.0b013e3181a11c64 10.1016/j.ajpath.2015.11.011 10.1155/2010/932371 10.1126/scitranslmed.3004952 10.1097/01.pas.0000180854.28831.77 10.1016/S0140-6736(15)01224-6 10.1097/AOG.0b013e3182783c2f 10.1002/path.2091 10.1038/nature09515 10.1016/j.humpath.2006.11.010 10.1093/jnci/dju410
ContentType	Journal Article
Copyright	The Author(s) 2017 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml	– notice: The Author(s) 2017 – notice: 2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM DOA
DOI	10.1038/s41467-017-00962-1
DatabaseName	SpringerOpen Free (Free internet resource, activated by CARLI) CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic CrossRef Publicly Available Content Database MEDLINE
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals (WRLC) url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2041-1723
EndPage	11
ExternalDocumentID	oai_doaj_org_article_733833a56c6b45119ce856baf3827bd9 PMC5653668 29061967 10_1038_s41467_017_00962_1
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NCI NIH HHS grantid: P30 CA006973 – fundername: NCI NIH HHS grantid: P50 CA083636 – fundername: NCI NIH HHS grantid: U01 CA200469 – fundername: NIGMS NIH HHS grantid: T32 GM007814 – fundername: NCI NIH HHS grantid: R01 CA121113 – fundername: NCI NIH HHS grantid: U01 CA152990
GroupedDBID	--- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BAPOH BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX AFFHD CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 SOI 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c606t-f47f2f20d8a2457ae1b499bb91d7e24e18cb8f5d7e8728277bc1aa2d63c486d63
IEDL.DBID	M7P
ISICitedReferencesCount	546
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000413404800004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2041-1723
IngestDate	Fri Oct 03 12:44:07 EDT 2025 Tue Nov 04 01:57:14 EST 2025 Fri Sep 05 11:30:52 EDT 2025 Sat Nov 29 15:05:18 EST 2025 Thu Apr 03 06:55:30 EDT 2025 Tue Nov 18 22:15:45 EST 2025 Sat Nov 29 03:37:41 EST 2025 Fri Feb 21 02:42:00 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c606t-f47f2f20d8a2457ae1b499bb91d7e24e18cb8f5d7e8728277bc1aa2d63c486d63
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0003-0136-4271 0000-0003-1195-438X 0000-0002-6912-6977
OpenAccessLink	https://www.proquest.com/docview/1954386931?pq-origsite=%requestingapplication%
PMID	29061967
PQID	1954386931
PQPubID	546298
PageCount	11
ParticipantIDs	doaj_primary_oai_doaj_org_article_733833a56c6b45119ce856baf3827bd9 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5653668 proquest_miscellaneous_1955063026 proquest_journals_1954386931 pubmed_primary_29061967 crossref_citationtrail_10_1038_s41467_017_00962_1 crossref_primary_10_1038_s41467_017_00962_1 springer_journals_10_1038_s41467_017_00962_1
PublicationCentury	2000
PublicationDate	2017-10-23
PublicationDateYYYYMMDD	2017-10-23
PublicationDate_xml	– month: 10 year: 2017 text: 2017-10-23 day: 23
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Nature communications
PublicationTitleAbbrev	Nat Commun
PublicationTitleAlternate	Nat Commun
PublicationYear	2017
Publisher	Nature Publishing Group UK Nature Publishing Group Nature Portfolio
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio
References	Patch (CR12) 2015; 521 Rebbeck (CR34) 2002; 346 Piek (CR14) 2003; 90 Kwon (CR37) 2013; 121 Jones (CR29) 2008; 105 Kurman, Shih Ie (CR7) 2010; 34 Piek (CR15) 2001; 195 CR36 Nik, Vang, Shih Ie, Kurman (CR22) 2014; 9 Leeper (CR26) 2002; 87 Eberle (CR43) 2010; 12 Cass (CR13) 2005; 106 Jones (CR45) 2015; 7 Yachida (CR24) 2010; 467 Perets (CR28) 2013; 24 Haber, Velculescu (CR41) 2014; 4 Menon, Griffin, Gentry-Maharaj (CR4) 2014; 132 Eckert (CR33) 2016; 6 Bashashati (CR21) 2013; 231 Parker (CR39) 2009; 113 Ferlay (CR1) 2013; 49 Siegel, Miller, Jemal (CR2) 2015; 65 Bertotti (CR44) 2015; 526 Lee (CR17) 2007; 211 Karnezis, Cho (CR32) 2016; 144 Karst, Drapkin (CR8) 2010; 2010 McDaniel (CR20) 2015; 1 Li (CR47) 2009; 25 Roh (CR27) 2010; 23 Conner (CR31) 2014; 132 Kuhn (CR19) 2012; 226 McPherson (CR23) 2016; 48 Kinde (CR42) 2013; 5 Kindelberger (CR18) 2007; 31 Perets, Drapkin (CR30) 2016; 76 Kauff (CR35) 2002; 346 Levanon, Crum, Drapkin (CR9) 2008; 26 McAlpine (CR38) 2014; 210 Kurman, Shih Ie (CR6) 2016; 186 Niknafs, Beleva-Guthrie, Naiman, Karchin (CR25) 2015; 11 Bowtell (CR10) 2015; 15 CR40 Cress, Chen, Morris, Petersen, Leiserowitz (CR3) 2015; 126 Medeiros (CR16) 2006; 30 (CR11) 2011; 474 Jacobs (CR5) 2016; 387 Olshen, Venkatraman, Lucito, Wigler (CR46) 2004; 5 RL Siegel (962_CR2) 2015; 65 AM Karst (962_CR8) 2010; 2010 S Jones (962_CR45) 2015; 7 RD Cress (962_CR3) 2015; 126 A Bertotti (962_CR44) 2015; 526 K Levanon (962_CR9) 2008; 26 WH Parker (962_CR39) 2009; 113 FC Eberle (962_CR43) 2010; 12 I Cass (962_CR13) 2005; 106 MH Roh (962_CR27) 2010; 23 AS McDaniel (962_CR20) 2015; 1 ND Kauff (962_CR35) 2002; 346 962_CR40 A Bashashati (962_CR21) 2013; 231 JR Conner (962_CR31) 2014; 132 H Li (962_CR47) 2009; 25 MA Eckert (962_CR33) 2016; 6 RJ Kurman (962_CR6) 2016; 186 K Leeper (962_CR26) 2002; 87 DD Bowtell (962_CR10) 2015; 15 AN Karnezis (962_CR32) 2016; 144 JM Piek (962_CR14) 2003; 90 JS Kwon (962_CR37) 2013; 121 J Ferlay (962_CR1) 2013; 49 U Menon (962_CR4) 2014; 132 JN McAlpine (962_CR38) 2014; 210 R Perets (962_CR28) 2013; 24 DA Haber (962_CR41) 2014; 4 IJ Jacobs (962_CR5) 2016; 387 A McPherson (962_CR23) 2016; 48 N Niknafs (962_CR25) 2015; 11 S Jones (962_CR29) 2008; 105 F Medeiros (962_CR16) 2006; 30 JM Piek (962_CR15) 2001; 195 R Perets (962_CR30) 2016; 76 AM Patch (962_CR12) 2015; 521 Y Lee (962_CR17) 2007; 211 DW Kindelberger (962_CR18) 2007; 31 RJ Kurman (962_CR7) 2010; 34 I Kinde (962_CR42) 2013; 5 962_CR36 E Kuhn (962_CR19) 2012; 226 NN Nik (962_CR22) 2014; 9 Cancer Genome Atlas Research Network (962_CR11) 2011; 474 TR Rebbeck (962_CR34) 2002; 346 S Yachida (962_CR24) 2010; 467 AB Olshen (962_CR46) 2004; 5
References_xml	– volume: 195 start-page: 451 year: 2001 end-page: 456 ident: CR15 article-title: Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer publication-title: J. Pathol. doi: 10.1002/path.1000 – volume: 526 start-page: 263 year: 2015 end-page: 267 ident: CR44 article-title: The genomic landscape of response to EGFR blockade in colorectal cancer publication-title: Nature doi: 10.1038/nature14969 – volume: 11 year: 2015 ident: CR25 article-title: SubClonal hierarchy inference from somatic mutations: automatic reconstruction of cancer evolutionary trees from multi-region next generation sequencing publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1004416 – volume: 48 start-page: 758 year: 2016 end-page: 767 ident: CR23 article-title: Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer publication-title: Nat. Genet. doi: 10.1038/ng.3573 – volume: 126 start-page: 491 year: 2015 end-page: 497 ident: CR3 article-title: Characteristics of long-term survivors of epithelial ovarian cancer publication-title: Obstet. Gynecol. doi: 10.1097/AOG.0000000000000981 – volume: 25 start-page: 2078 year: 2009 end-page: 2079 ident: CR47 article-title: The sequence alignment/map format and SAMtools publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 26 start-page: 5284 year: 2008 end-page: 5293 ident: CR9 article-title: New insights into the pathogenesis of serous ovarian cancer and its clinical impact publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2008.18.1107 – volume: 226 start-page: 421 year: 2012 end-page: 426 ident: CR19 article-title: TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma--evidence supporting the clonal relationship of the two lesions publication-title: J. Pathol. doi: 10.1002/path.3023 – volume: 76 start-page: 10 year: 2016 end-page: 17 ident: CR30 article-title: It’s totally tubular…riding the new wave of ovarian cancer research publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-15-1382 – volume: 132 start-page: 280 year: 2014 end-page: 286 ident: CR31 article-title: Outcome of unexpected adnexal neoplasia discovered during risk reduction salpingo-oophorectomy in women with germ-line BRCA1 or BRCA2 mutations publication-title: Gynecol. Oncol. doi: 10.1016/j.ygyno.2013.12.009 – volume: 87 start-page: 52 year: 2002 end-page: 56 ident: CR26 article-title: Pathologic findings in prophylactic oophorectomy specimens in high-risk women publication-title: Gynecol. Oncol. doi: 10.1006/gyno.2002.6779 – volume: 7 year: 2015 ident: CR45 article-title: Personalized genomic analyses for cancer mutation discovery and interpretation publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaa7161 – volume: 6 start-page: 1342 year: 2016 end-page: 1351 ident: CR33 article-title: Genomics of ovarian cancer progression reveals diverse metastatic trajectories including intraepithelial metastasis to the fallopian tube publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-16-0607 – volume: 1 start-page: 1128 year: 2015 end-page: 1132 ident: CR20 article-title: Next-generation sequencing of tubal intraepithelial carcinomas publication-title: JAMA Oncol doi: 10.1001/jamaoncol.2015.1618 – volume: 49 start-page: 1374 year: 2013 end-page: 1403 ident: CR1 article-title: Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012 publication-title: Eur. J. Cancer. doi: 10.1016/j.ejca.2012.12.027 – volume: 24 start-page: 751 year: 2013 end-page: 765 ident: CR28 article-title: Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.10.013 – volume: 15 start-page: 668 year: 2015 end-page: 679 ident: CR10 article-title: Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer publication-title: Nat. Rev. Cancer. doi: 10.1038/nrc4019 – volume: 210 start-page: 471.e1 year: 2014 end-page: 471.e11 ident: CR38 article-title: Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention publication-title: Am. J. Obstet. Gynecol. doi: 10.1016/j.ajog.2014.01.003 – ident: CR40 – volume: 132 start-page: 490 year: 2014 end-page: 495 ident: CR4 article-title: Ovarian cancer screening--current status, future directions publication-title: Gynecol. Oncol. doi: 10.1016/j.ygyno.2013.11.030 – volume: 106 start-page: 1327 year: 2005 end-page: 1334 ident: CR13 article-title: BRCA-mutation-associated fallopian tube carcinoma: a distinct clinical phenotype? publication-title: Obstet. Gynecol. doi: 10.1097/01.AOG.0000187892.78392.3f – volume: 31 start-page: 161 year: 2007 end-page: 169 ident: CR18 article-title: Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship publication-title: Am. J. Surg. Pathol. doi: 10.1097/01.pas.0000213335.40358.47 – volume: 5 start-page: 557 year: 2004 end-page: 572 ident: CR46 article-title: Circular binary segmentation for the analysis of array-based DNA copy number data publication-title: Biostatistics doi: 10.1093/biostatistics/kxh008 – volume: 144 start-page: 5 year: 2016 end-page: 7 ident: CR32 article-title: Of mice and women - non-ovarian origins of “ovarian” cancer publication-title: Gynecol. Oncol. doi: 10.1016/j.ygyno.2016.11.039 – volume: 4 start-page: 650 year: 2014 end-page: 661 ident: CR41 article-title: Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-13-1014 – volume: 12 start-page: 394 year: 2010 end-page: 401 ident: CR43 article-title: Immunoguided laser assisted microdissection techniques for DNA methylation analysis of archival tissue specimens publication-title: J. Mol. Diagn. doi: 10.2353/jmoldx.2010.090200 – volume: 346 start-page: 1616 year: 2002 end-page: 1622 ident: CR34 article-title: Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa012158 – volume: 231 start-page: 21 year: 2013 end-page: 34 ident: CR21 article-title: Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling publication-title: J. Pathol. doi: 10.1002/path.4230 – volume: 9 start-page: 27 year: 2014 end-page: 45 ident: CR22 article-title: Origin and pathogenesis of pelvic (ovarian, tubal, and primary peritoneal) serous carcinoma publication-title: Annu. Rev. Pathol. doi: 10.1146/annurev-pathol-020712-163949 – volume: 105 start-page: 4283 year: 2008 end-page: 4288 ident: CR29 article-title: Comparative lesion sequencing provides insights into tumor evolution publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0712345105 – volume: 34 start-page: 433 year: 2010 end-page: 443 ident: CR7 article-title: The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory publication-title: Am. J. Surg. Pathol. doi: 10.1097/PAS.0b013e3181cf3d79 – volume: 474 start-page: 609 year: 2011 end-page: 615 ident: CR11 article-title: Integrated genomic analyses of ovarian carcinoma publication-title: Nature doi: 10.1038/nature10166 – volume: 521 start-page: 489 year: 2015 end-page: 494 ident: CR12 article-title: Whole-genome characterization of chemoresistant ovarian cancer publication-title: Nature doi: 10.1038/nature14410 – volume: 90 year: 2003 ident: CR14 article-title: BRCA1/2-related ovarian cancers are of tubal origin: a hypothesis publication-title: Gynecol. Oncol. doi: 10.1016/S0090-8258(03)00365-2 – volume: 23 start-page: 1316 year: 2010 end-page: 1324 ident: CR27 article-title: High-grade fimbrial-ovarian carcinomas are unified by altered p53, PTEN and PAX2 expression publication-title: Mod. Pathol. doi: 10.1038/modpathol.2010.119 – volume: 346 start-page: 1609 year: 2002 end-page: 1615 ident: CR35 article-title: Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa020119 – volume: 65 start-page: 5 year: 2015 end-page: 29 ident: CR2 article-title: Cancer statistics, 2015 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21254 – volume: 113 start-page: 1027 year: 2009 end-page: 1037 ident: CR39 article-title: Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses’ health study publication-title: Obstet. Gynecol. doi: 10.1097/AOG.0b013e3181a11c64 – volume: 186 start-page: 733 year: 2016 end-page: 747 ident: CR6 article-title: The dualistic model of ovarian carcinogenesis: revisited, revised, and expanded publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2015.11.011 – volume: 2010 year: 2010 ident: CR8 article-title: Ovarian cancer pathogenesis: a model in evolution publication-title: J. Oncol. doi: 10.1155/2010/932371 – ident: CR36 – volume: 5 year: 2013 ident: CR42 article-title: Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3004952 – volume: 30 start-page: 230 year: 2006 end-page: 236 ident: CR16 article-title: The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome publication-title: Am. J. Surg. Pathol. doi: 10.1097/01.pas.0000180854.28831.77 – volume: 387 start-page: 945 year: 2016 end-page: 956 ident: CR5 article-title: Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(15)01224-6 – volume: 121 start-page: 14 year: 2013 end-page: 24 ident: CR37 article-title: Prophylactic salpingectomy and delayed oophorectomy as an alternative for BRCA mutation carriers publication-title: Obstet. Gynecol. doi: 10.1097/AOG.0b013e3182783c2f – volume: 211 start-page: 26 year: 2007 end-page: 35 ident: CR17 article-title: A candidate precursor to serous carcinoma that originates in the distal fallopian tube publication-title: J. Pathol. doi: 10.1002/path.2091 – volume: 467 start-page: 1114 year: 2010 end-page: 1117 ident: CR24 article-title: Distant metastasis occurs late during the genetic evolution of pancreatic cancer publication-title: Nature doi: 10.1038/nature09515 – volume: 34 start-page: 433 year: 2010 ident: 962_CR7 publication-title: Am. J. Surg. Pathol. doi: 10.1097/PAS.0b013e3181cf3d79 – volume: 474 start-page: 609 year: 2011 ident: 962_CR11 publication-title: Nature doi: 10.1038/nature10166 – volume: 195 start-page: 451 year: 2001 ident: 962_CR15 publication-title: J. Pathol. doi: 10.1002/path.1000 – volume: 30 start-page: 230 year: 2006 ident: 962_CR16 publication-title: Am. J. Surg. Pathol. doi: 10.1097/01.pas.0000180854.28831.77 – volume: 4 start-page: 650 year: 2014 ident: 962_CR41 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-13-1014 – volume: 521 start-page: 489 year: 2015 ident: 962_CR12 publication-title: Nature doi: 10.1038/nature14410 – volume: 113 start-page: 1027 year: 2009 ident: 962_CR39 publication-title: Obstet. Gynecol. doi: 10.1097/AOG.0b013e3181a11c64 – volume: 526 start-page: 263 year: 2015 ident: 962_CR44 publication-title: Nature doi: 10.1038/nature14969 – volume: 132 start-page: 490 year: 2014 ident: 962_CR4 publication-title: Gynecol. Oncol. doi: 10.1016/j.ygyno.2013.11.030 – volume: 121 start-page: 14 year: 2013 ident: 962_CR37 publication-title: Obstet. Gynecol. doi: 10.1097/AOG.0b013e3182783c2f – volume: 6 start-page: 1342 year: 2016 ident: 962_CR33 publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-16-0607 – volume: 65 start-page: 5 year: 2015 ident: 962_CR2 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21254 – volume: 90 year: 2003 ident: 962_CR14 publication-title: Gynecol. Oncol. doi: 10.1016/S0090-8258(03)00365-2 – volume: 346 start-page: 1616 year: 2002 ident: 962_CR34 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa012158 – volume: 9 start-page: 27 year: 2014 ident: 962_CR22 publication-title: Annu. Rev. Pathol. doi: 10.1146/annurev-pathol-020712-163949 – volume: 346 start-page: 1609 year: 2002 ident: 962_CR35 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa020119 – volume: 144 start-page: 5 year: 2016 ident: 962_CR32 publication-title: Gynecol. Oncol. doi: 10.1016/j.ygyno.2016.11.039 – volume: 24 start-page: 751 year: 2013 ident: 962_CR28 publication-title: Cancer Cell doi: 10.1016/j.ccr.2013.10.013 – volume: 31 start-page: 161 year: 2007 ident: 962_CR18 publication-title: Am. J. Surg. Pathol. doi: 10.1097/01.pas.0000213335.40358.47 – volume: 5 start-page: 557 year: 2004 ident: 962_CR46 publication-title: Biostatistics doi: 10.1093/biostatistics/kxh008 – volume: 231 start-page: 21 year: 2013 ident: 962_CR21 publication-title: J. Pathol. doi: 10.1002/path.4230 – volume: 87 start-page: 52 year: 2002 ident: 962_CR26 publication-title: Gynecol. Oncol. doi: 10.1006/gyno.2002.6779 – volume: 467 start-page: 1114 year: 2010 ident: 962_CR24 publication-title: Nature doi: 10.1038/nature09515 – volume: 211 start-page: 26 year: 2007 ident: 962_CR17 publication-title: J. Pathol. doi: 10.1002/path.2091 – volume: 23 start-page: 1316 year: 2010 ident: 962_CR27 publication-title: Mod. Pathol. doi: 10.1038/modpathol.2010.119 – volume: 387 start-page: 945 year: 2016 ident: 962_CR5 publication-title: Lancet doi: 10.1016/S0140-6736(15)01224-6 – volume: 210 start-page: 471.e1 year: 2014 ident: 962_CR38 publication-title: Am. J. Obstet. Gynecol. doi: 10.1016/j.ajog.2014.01.003 – ident: 962_CR40 doi: 10.1016/j.humpath.2006.11.010 – volume: 48 start-page: 758 year: 2016 ident: 962_CR23 publication-title: Nat. Genet. doi: 10.1038/ng.3573 – ident: 962_CR36 doi: 10.1093/jnci/dju410 – volume: 15 start-page: 668 year: 2015 ident: 962_CR10 publication-title: Nat. Rev. Cancer. doi: 10.1038/nrc4019 – volume: 105 start-page: 4283 year: 2008 ident: 962_CR29 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0712345105 – volume: 2010 year: 2010 ident: 962_CR8 publication-title: J. Oncol. doi: 10.1155/2010/932371 – volume: 76 start-page: 10 year: 2016 ident: 962_CR30 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-15-1382 – volume: 49 start-page: 1374 year: 2013 ident: 962_CR1 publication-title: Eur. J. Cancer. doi: 10.1016/j.ejca.2012.12.027 – volume: 12 start-page: 394 year: 2010 ident: 962_CR43 publication-title: J. Mol. Diagn. doi: 10.2353/jmoldx.2010.090200 – volume: 132 start-page: 280 year: 2014 ident: 962_CR31 publication-title: Gynecol. Oncol. doi: 10.1016/j.ygyno.2013.12.009 – volume: 1 start-page: 1128 year: 2015 ident: 962_CR20 publication-title: JAMA Oncol doi: 10.1001/jamaoncol.2015.1618 – volume: 25 start-page: 2078 year: 2009 ident: 962_CR47 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 11 year: 2015 ident: 962_CR25 publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1004416 – volume: 5 year: 2013 ident: 962_CR42 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.3004952 – volume: 7 year: 2015 ident: 962_CR45 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaa7161 – volume: 126 start-page: 491 year: 2015 ident: 962_CR3 publication-title: Obstet. Gynecol. doi: 10.1097/AOG.0000000000000981 – volume: 106 start-page: 1327 year: 2005 ident: 962_CR13 publication-title: Obstet. Gynecol. doi: 10.1097/01.AOG.0000187892.78392.3f – volume: 186 start-page: 733 year: 2016 ident: 962_CR6 publication-title: Am. J. Pathol. doi: 10.1016/j.ajpath.2015.11.011 – volume: 26 start-page: 5284 year: 2008 ident: 962_CR9 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2008.18.1107 – volume: 226 start-page: 421 year: 2012 ident: 962_CR19 publication-title: J. Pathol. doi: 10.1002/path.3023
SSID	ssj0000391844
Score	2.6781745
Snippet	High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube... It has previously been proposed that high-grade serous ovarian carcinoma (HGSOC) may originate from the fallopian tube. Here, the authors analyze genetic...
SourceID	doaj pubmedcentral proquest pubmed crossref springer
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	1093
SubjectTerms	631/67/1517/1709 631/67/69 Aberration Alleles BRCA1 protein BRCA2 protein Breast cancer Cancer Copy number Cystadenocarcinoma, Serous - genetics DNA Copy Number Variations - genetics Etiology Evolution Fallopian tube Fallopian Tube Neoplasms - metabolism Fallopian Tube Neoplasms - pathology Fallopian Tubes - metabolism Fallopian Tubes - pathology Female Genital cancers Gynecological cancer Humanities and Social Sciences Humans Immunohistochemistry Laser Capture Microdissection Lesions Metastases Metastasis multidisciplinary Neoplasms, Cystic, Mucinous, and Serous - metabolism Neoplasms, Cystic, Mucinous, and Serous - pathology Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics p53 Protein Patients PTEN protein Science Science (multidisciplinary) Signatures
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9wwDBfj6GAvo91n2tvwYG9baGwntvPYdjv2MMoettE3YzvOdlDScpce9L-v5OSOu331ZU8hsUyEJNsSkn8CeKtFo6R3VPBEacbGidx5LnPZlBX36GK7BDz__bM-PzcXF_WXrVZfVBM2wAMPgjvWFENJV6mgPGFp1dRnU3nXSiO0b9LVvULXW8FU2oNljaFLOd6SKaQ5XpZpT6BNmdx2kfOdkygB9v_Jy_y9WPKXjGk6iGb78Hj0INnJwPkBPIjdE3g49JS8fQofqHKD_Vi4JjI0Lwzs2dUKA2LXsUB9gzoqCGJjP6w-snnH0AdkLSXgr4mqv_HxGXybffx69ikfWyXkASOQPm9L3YpWFI1xoqy0i0nO3te80VGUkZvgTVvhi9EYZGntA3eO9BRKo_DxHCbdVRdfAgtKuLINXGLsRElV1xY4z3PTaPSViiIDvhabDSOOOLWzuLQpny2NHURtUdQ2idryDN5t5lwPKBr_pD4lbWwoCQE7fUC7sKNd2PvsIoPpWpd2XJZLS_B20qha4j_ebIZxQVGWxHURdUI0FQGRCZXBi0H1G04IGx-3LJ2B3jGKHVZ3R7r5zwTajY6zVMpk8H5tPlts_VUUh_9DFEfwSJDd44kr5BQm_eImvoK9sOrny8XrtHDuALdmF7M priority: 102 providerName: Directory of Open Access Journals
Title	High grade serous ovarian carcinomas originate in the fallopian tube
URI	https://link.springer.com/article/10.1038/s41467-017-00962-1 https://www.ncbi.nlm.nih.gov/pubmed/29061967 https://www.proquest.com/docview/1954386931 https://www.proquest.com/docview/1955063026 https://pubmed.ncbi.nlm.nih.gov/PMC5653668 https://doaj.org/article/733833a56c6b45119ce856baf3827bd9
Volume	8
WOSCitedRecordID	wos000413404800004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals (WRLC) customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources (ISSN International Center) customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: P5Z dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M7P dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: 7X7 dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Proquest Central customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: BENPR dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: PIMPY dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RFiQuvEsDZWUkbhA1tpPYOSEKrUCCVYQALVws20nKSii73WQr8e_xON7A8uiFS6LEjmR7Hp7xTL4BeCJYlXOjMeEJw4yVZrE2lMe8SjNqnImtPfD8p7diOpWzWVGGA7cupFVudKJX1NXC4hn5ESKTcZkXnD5fnsdYNQqjq6GExg7sIUoC86l75XjGgujnMk3DvzIJl0dd6jUDqmY03llMt_YjD9v_N1vzz5TJ3-Kmfjs6vfm_E7kFN4IhSl4MnHMbrtTtHbg2lKb8fhdeYQIIOVvpqiaOSxfrjiwunF-tW2Kx_FCLeUUklNXqazJviTMlSYNx_CX26temvgcfT08-vHwdh4oLsXWOTB83qWhYw5JKapZmQteeXMYUtBI1S2sqrZFN5h6kcL6aEMZSrZHcNpW5u-3Dbrto6wMgNmc6bSzlzgXD2KxuEvedobISzuRKkgjoZt2VDXDkWBXjm_JhcS7VQCvlaKU8rRSN4On4zXIA47i09zGSc-yJQNr-xWJ1poJcKoEuOtdZbnODUG0FlnHNjW64m56piggON1RUQbo79ZOEETwem51cYrBFt7WjCfbJEM-M5RHcH3hnHAlC7DvNJyIQW1y1NdTtlnb-1WN_O_ub57mM4NmG_34Z1j-X4sHls3gI1xmKhNuSGT-E3X61rh_BVXvRz7vVBHbETPirnMDe8cm0fD_xRxcTL23uWmZfXEv55l35-QdPqy16
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VLQguvB-BAkaCE0SN7WzsPSAElKqrbld7KKicjO04ZSWUXfZR1D_Fb2Qmj4Xl0VsPnKIkTmTH34xnPJP5AJ4qkWfSWUp4ojBjbkVsHZexzNMud2hi26rw_IeBGg710VFvtAHf239hKK2y1YmVos4nnvbIt6kymdRZT_JX068xsUZRdLWl0KhhsR9Ov6HLNn_Z38H5fSbE7rvDt3txwyoQezTWF3GRqkIUIsm1FWlX2VB1ybkez1UQaeDaO1108UQr9EeUcp5bS0Pyqc7wgO-9AJspgb0Dm6P-wejjaleH6q3rNG3-zkmk3p6nlS6ixYDcBRHztRWwIgr4m3X7Z5Lmb5HaagHcvfa_fbrrcLUxtdnrWjZuwEYob8Klmnzz9BbsUIoLO57ZPDCUw8lyziYnFuWxZJ4IlkrKnGINcdgisHHJ0FhmBWUqTKnVYunCbXh_LkO4A51yUoZ7wHwmbFp4LtHJpOizLRJ8znGdKzQqkyQC3s6z8U3BdeL9-GKqwL_UpsaGQWyYChuGR_B89cy0LjdyZus3BJ9VSyoVXl2YzI5No3mMok0IabuZzxwVo-sRUW3mbCFxeC7vRbDVosY0-mtufkImgier26h5KJxky4BzQm26VLFNZBHcrbG66gmRCKBuVxGoNRSvdXX9Tjn-XFU3Rw9DZpmO4EWL91-69c9Pcf_sUTyGy3uHBwMz6A_3H8AVQeKIBoiQW9BZzJbhIVz0J4vxfPaokWgGn85bEn4AkpOFUQ
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6V8hAX3o9AASPBCaJN7CT2HhAClhVVq9UeAFVcXNtxykoou-yjqH-NX8eMkywsj9564BQlcSI7_mY845nMB_BE8rIQ1lDCE4UZS8NjY1MRizLLU4smtgmF5z_uy9FIHRz0x1vwvfsXhtIqO50YFHU5dbRH3qPKZEIVfZH2qjYtYjwYvpx9jYlBiiKtHZ1GA5E9f_IN3bfFi90BzvVTzodv3795F7cMA7FDw30ZV5mseMWTUhme5dL40D1r-2kpPc98qpxVVY4nSqJvIqV1qTE0PJepAg_43nNwXqKPSemE4_zTen-HKq-rLGv_00mE6i2yoJVoWSDHgcfpxloYKAP-Zuf-ma75W8w2LIXDq__zR7wGV1oDnL1qJOY6bPn6BlxsKDlPbsKAEl_Y0dyUnqF0TlcLNj02KKU1c0S7VFM-FWvpxJaeTWqGJjSrKH9hRq2WK-tvwYczGcJt2K6ntb8LzBXcZJVLBbqeFJM2VYLP2VSVEk3NJIkg7eZcu7YMO7GBfNEhHUAo3eBEI050wIlOI3i2fmbWFCE5tfVrgtK6JRUQDxem8yPd6iMtaWtCmLxwhaUSdX2iry2sqQQOz5b9CHY6BOlWqy30T_hE8Hh9G_URBZlM7XFOqE1Oddx4EcGdBrfrnhC1AGp8GYHcQPRGVzfv1JPPoeY5-h2iKFQEzzvs_9Ktf36Ke6eP4hFcQvjr_d3R3n24zEky0SrhYge2l_OVfwAX3PFyspg_DKLN4PCsxeAHd5OMtA
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=High+grade+serous+ovarian+carcinomas+originate+in+the+fallopian+tube&rft.jtitle=Nature+communications&rft.au=Labidi-Galy%2C+S.+Intidhar&rft.au=Papp%2C+Eniko&rft.au=Hallberg%2C+Dorothy&rft.au=Niknafs%2C+Noushin&rft.date=2017-10-23&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=8&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-017-00962-1&rft.externalDocID=10_1038_s41467_017_00962_1
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon