Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

Thrombocytosis is present in more than 30% of patients with solid malignancies and correlates with worsened patient survival. Tumor cell interaction with various cellular components of the tumor microenvironment including platelets is crucial for tumor growth and metastasis. Although it is known tha...

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Bibliographic Details
Published in:	Nature communications Vol. 8; no. 1; pp. 310 - 15
Main Authors:	Haemmerle, Monika, Taylor, Morgan L., Gutschner, Tony, Pradeep, Sunila, Cho, Min Soon, Sheng, Jianting, Lyons, Yasmin M., Nagaraja, Archana S., Dood, Robert L., Wen, Yunfei, Mangala, Lingegowda S., Hansen, Jean M., Rupaimoole, Rajesha, Gharpure, Kshipra M., Rodriguez-Aguayo, Cristian, Yim, Sun Young, Lee, Ju-Seog, Ivan, Cristina, Hu, Wei, Lopez-Berestein, Gabriel, Wong, Stephen T., Karlan, Beth Y., Levine, Douglas A., Liu, Jinsong, Afshar-Kharghan, Vahid, Sood, Anil K.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 21.08.2017 Nature Publishing Group Nature Portfolio
Subjects:	631/67/1517/1709 631/80/304 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Anoikis Blood Platelets - cytology Blood Platelets - metabolism Cancer Cell Line, Tumor Coculture Techniques Female Gene Expression Profiling - methods Humanities and Social Sciences Humans Metastases Metastasis Mice, Inbred C57BL Mice, Nude multidisciplinary Neoplasm Metastasis Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phosphoproteins - genetics Phosphoproteins - metabolism Platelets RhoA protein RNA Interference Science Science (multidisciplinary) Signal Transduction Transcription Factors Translocation Transplantation, Heterologous Tumors YAP-Signaling Proteins Yes-associated protein
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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