Fatal heart disease among cancer patients

As the overlap between heart disease and cancer patients increases as cancer-specific mortality is decreasing and the surviving population is aging, it is necessary to identify cancer patients who are at an increased risk of death from heart disease. The purpose of this study is to identify cancer p...

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Bibliographic Details
Published in:Nature communications Vol. 11; no. 1; pp. 2011 - 8
Main Authors: Stoltzfus, Kelsey C., Zhang, Ying, Sturgeon, Kathleen, Sinoway, Lawrence I., Trifiletti, Daniel M., Chinchilli, Vernon M., Zaorsky, Nicholas G.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 24.04.2020
Nature Publishing Group
Nature Portfolio
Subjects:
631/67/2324
Adult
Age Factors
Aged
Aged, 80 and over
Aging
Black or African American - statistics & numerical data
Cancer
Cancer Survivors - statistics & numerical data
Cardiovascular disease
Cardiovascular diseases
Cause of Death - trends
Coronary artery disease
Death
Fatalities
Female
Heart
Heart diseases
Heart Diseases - complications
Heart Diseases - mortality
Heart Diseases - prevention & control
Heart rate
Humanities and Social Sciences
Humans
Male
Marital Status - statistics & numerical data
Middle Aged
Mortality
multidisciplinary
Neoplasms - complications
Risk
Risk Factors
Science
Science (multidisciplinary)
Sex Factors
United States - epidemiology
United States
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:As the overlap between heart disease and cancer patients increases as cancer-specific mortality is decreasing and the surviving population is aging, it is necessary to identify cancer patients who are at an increased risk of death from heart disease. The purpose of this study is to identify cancer patients at highest risk of fatal heart disease compared to the general population and other cancer patients at risk of death during the study time period. Here we report that 394,849 of the 7,529,481 cancer patients studied died of heart disease. The heart disease-specific mortality rate is 10.61/10,000-person years, and the standardized mortality ratio (SMR) of fatal heart disease is 2.24 (95% CI: 2.23–2.25). Compared to other cancer patients, patients who are older, male, African American, and unmarried are at a greatest risk of fatal heart disease. For almost all cancer survivors, the risk of fatal heart disease increases with time. As the overlap between heart disease and cancer patients increases as cancer-specific mortality is decreasing, identifying cancer patients who are at an increased risk of death from heart disease is important. Here the authors report on risk of death from heart diseases among more than 7.5 million cancer patients.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-020-15639-5