High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer m...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 4358 - 14
Main Authors:	Labbé, David P., Zadra, Giorgia, Yang, Meng, Reyes, Jaime M., Lin, Charles Y., Cacciatore, Stefano, Ebot, Ericka M., Creech, Amanda L., Giunchi, Francesca, Fiorentino, Michelangelo, Elfandy, Habiba, Syamala, Sudeepa, Karoly, Edward D., Alshalalfa, Mohammed, Erho, Nicholas, Ross, Ashley, Schaeffer, Edward M., Gibb, Ewan A., Takhar, Mandeep, Den, Robert B., Lehrer, Jonathan, Karnes, R. Jeffrey, Freedland, Stephen J., Davicioni, Elai, Spratt, Daniel E., Ellis, Leigh, Jaffe, Jacob D., DʼAmico, Anthony V., Kantoff, Philip W., Bradner, James E., Mucci, Lorelei A., Chavarro, Jorge E., Loda, Massimo, Brown, Myles
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.09.2019 Nature Publishing Group Nature Portfolio
Subjects:	38/15 38/39 631/67/2324 631/67/2327 64/110 64/60 692/4028/67/589/466 692/499 692/53/2422 82/58 Aged Animals Cell Line, Tumor Cell Proliferation - drug effects Cell Proliferation - genetics Diet Diet, High-Fat - adverse effects Disease Progression Gene Expression Regulation, Neoplastic - drug effects High fat diet Humanities and Social Sciences Humans Low fat diet Male Metabolism Metabolome - drug effects Mice, Transgenic Middle Aged Mimicry multidisciplinary Myc protein Nutrient deficiency Prostate cancer Prostatic Neoplasms - etiology Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Rewiring Science Science (multidisciplinary) Transcription Tumor Burden - drug effects Tumor Burden - genetics Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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