Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

Patients with primary and bone metastatic breast cancer have significantly reduced survival and life quality. Due to the poor drug delivery efficiency of anti-metastasis therapy and the limited response rate of immunotherapy for breast cancer, effective treatment remains a formidable challenge. In t...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 4310 - 22
Main Authors:	Huang, Yanjuan, Guan, Zilin, Dai, Xiuling, Shen, Yifeng, Wei, Qin, Ren, Lingling, Jiang, Jingwen, Xiao, Zhanghong, Jiang, Yali, Liu, Di, Huang, Zeqian, Xu, Xiaoyu, Luo, Yong, Zhao, Chunshun
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.07.2021 Nature Publishing Group Nature Portfolio
Subjects:	13/2 13/21 13/31 13/51 14/1 14/19 14/34 14/5 59/5 631/67/1344 631/67/1347 631/67/322/803 64/60 Animals Antitumor activity Apoptosis - drug effects B7-H1 Antigen - antagonists & inhibitors Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - immunology Bone Neoplasms - secondary Bone tumors Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - pathology Cell death Cell Line, Tumor Cell Movement - drug effects Drug Carriers - chemistry Drug delivery Drug Delivery Systems Female Humanities and Social Sciences Humans I.R. radiation Immune Checkpoint Inhibitors - therapeutic use Immune response Immune system Immunogenic Cell Death - drug effects Immunogenicity Immunologic Memory - drug effects Immunotherapy Indoles - administration & dosage Indoles - chemistry Indoles - pharmacology Infrared Rays Macrophages Macrophages - chemistry Macrophages - transplantation Medical prognosis Metastases Metastasis multidisciplinary Nanomedicine Nanotechnology Near infrared radiation Organometallic Compounds - administration & dosage Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Oxaliplatin Oxaliplatin - administration & dosage Oxaliplatin - chemistry Oxaliplatin - pharmacology Patients PD-L1 protein Phenotypes Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - administration & dosage Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Prodrugs Prodrugs - administration & dosage Prodrugs - chemistry Prodrugs - pharmacology Quality of life Science Science (multidisciplinary) Survival Toxicity Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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