Combining streptozotocin and unilateral nephrectomy is an effective method for inducing experimental diabetic nephropathy in the ‘resistant’ C57Bl/6J mouse strain

Diabetic nephropathy (DN) is the leading cause of chronic kidney disease. Animal models are essential tools for designing new strategies to prevent DN. C57Bl/6 (B6) mice are widely used for transgenic mouse models, but are relatively resistant to DN. This study aims to identify the most effective me...

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Veröffentlicht in:	Scientific reports Jg. 8; H. 1; S. 5542 - 10
Hauptverfasser:	Uil, Melissa, Scantlebery, Angelique M. L., Butter, Loes M., Larsen, Per W. B., de Boer, Onno J., Leemans, Jaklien C., Florquin, Sandrine, Roelofs, Joris J. T. H.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 03.04.2018 Nature Publishing Group Nature Portfolio
Schlagworte:	13/51 14/28 14/63 38/77 64/60 692/308/1426 692/4022/1585/104 82/80 Animal diseases Animal models Animals Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - surgery Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - surgery Diabetic Nephropathies - etiology Diabetic Nephropathies - pathology Diabetic nephropathy Diet Disease Models, Animal High fat diet Humanities and Social Sciences Kidneys Lesions Male Mice Mice, Inbred C57BL multidisciplinary Nephrectomy Nephrectomy - adverse effects Nephropathy Rodents Science Science (multidisciplinary) Streptozocin Streptozocin - toxicity Transgenic mice
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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