Effective weight control via an implanted self-powered vagus nerve stimulation device

In vivo vagus nerve stimulation holds great promise in regulating food intake for obesity treatment. Here we present an implanted vagus nerve stimulation system that is battery-free and spontaneously responsive to stomach movement. The vagus nerve stimulation system comprises a flexible and biocompa...

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Vydáno v:Nature communications Ročník 9; číslo 1; s. 5349 - 10
Hlavní autoři: Yao, Guang, Kang, Lei, Li, Jun, Long, Yin, Wei, Hao, Ferreira, Carolina A., Jeffery, Justin J., Lin, Yuan, Cai, Weibo, Wang, Xudong
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 17.12.2018
Nature Publishing Group
Nature Portfolio
Témata:
13
14/63
3T3 Cells
631/378/1488/393
639/301/1005/1007
639/4077/4072/4062
639/925/357/995
692/700/2817
96/95
Adrenal glands
Animal models
Animals
Appetite Regulation
Batteries
Biocompatibility
Body weight
Cell Line
Eating
Electric power generation
Electric pulses
Food intake
Humanities and Social Sciences
Ions
Mice
multidisciplinary
Nanotechnology
Obesity - therapy
Peristalsis
Peristalsis - physiology
Rats
Rats, Sprague-Dawley
Science
Science (multidisciplinary)
Sensory neurons
Stimulation
Stomach
Stomach - physiology
Surgical implants
Therapeutic applications
Vagus nerve
Vagus Nerve - metabolism
Vagus Nerve Stimulation - instrumentation
Vagus Nerve Stimulation - methods
ISSN:2041-1723, 2041-1723
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Shrnutí:In vivo vagus nerve stimulation holds great promise in regulating food intake for obesity treatment. Here we present an implanted vagus nerve stimulation system that is battery-free and spontaneously responsive to stomach movement. The vagus nerve stimulation system comprises a flexible and biocompatible nanogenerator that is attached on the surface of stomach. It generates biphasic electric pulses in responsive to the peristalsis of stomach. The electric signals generated by this device can stimulate the vagal afferent fibers to reduce food intake and achieve weight control. This strategy is successfully demonstrated on rat models. Within 100 days, the average body weight is controlled at 350 g, 38% less than the control groups. This work correlates nerve stimulation with targeted organ functionality through a smart, self-responsive system, and demonstrated highly effective weight control. This work also provides a concept in therapeutic technology using artificial nerve signal generated from coordinated body activities. Developing new technologies for the neuromodulation of the vagus nerve can enable therapeutic strategies for body weight control in obese patients. Here, the authors present a battery-free self-powered implantable vagus nerve stimulation system that electrically responds to stomach movement.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-018-07764-z