Skeletal muscle transcriptome in healthy aging

Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22–...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 2014 - 16
Main Authors:	Tumasian, Robert A., Harish, Abhinav, Kundu, Gautam, Yang, Jen-Hao, Ubaida-Mohien, Ceereena, Gonzalez-Freire, Marta, Kaileh, Mary, Zukley, Linda M., Chia, Chee W., Lyashkov, Alexey, Wood, William H., Piao, Yulan, Coletta, Christopher, Ding, Jun, Gorospe, Myriam, Sen, Ranjan, De, Supriyo, Ferrucci, Luigi
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.04.2021 Nature Publishing Group Nature Portfolio
Subjects:	38/39 38/88 38/91 631/337/2019 692/698/1671/1668/1973 82/80 Adaptation Adipogenesis Adult Age Aged Aged, 80 and over Aging Damage accumulation Female Gene expression Gene Expression Profiling Healthy Aging - genetics Homeostasis Homeostasis - genetics Humanities and Social Sciences Humans Insulin Isoforms Male Middle Aged multidisciplinary Muscle, Skeletal - metabolism Muscles Muscular Diseases - genetics Musculoskeletal system Myogenesis Non-coding RNA Oxidative phosphorylation Phosphorylation Proteins Regression analysis Regression models RNA Isoforms - genetics RNA, Messenger - genetics RNA, Untranslated - genetics Science Science (multidisciplinary) Senescence Skeletal muscle Transcriptome Transcriptomes Young Adult
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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