Skeletal muscle transcriptome in healthy aging

Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22–...

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Veröffentlicht in:Nature communications Jg. 12; H. 1; S. 2014 - 16
Hauptverfasser: Tumasian, Robert A., Harish, Abhinav, Kundu, Gautam, Yang, Jen-Hao, Ubaida-Mohien, Ceereena, Gonzalez-Freire, Marta, Kaileh, Mary, Zukley, Linda M., Chia, Chee W., Lyashkov, Alexey, Wood, William H., Piao, Yulan, Coletta, Christopher, Ding, Jun, Gorospe, Myriam, Sen, Ranjan, De, Supriyo, Ferrucci, Luigi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 01.04.2021
Nature Publishing Group
Nature Portfolio
Schlagworte:
38/39
38/88
38/91
631/337/2019
692/698/1671/1668/1973
82/80
Adaptation
Adipogenesis
Adult
Age
Aged
Aged, 80 and over
Aging
Damage accumulation
Female
Gene expression
Gene Expression Profiling
Healthy Aging - genetics
Homeostasis
Homeostasis - genetics
Humanities and Social Sciences
Humans
Insulin
Isoforms
Male
Middle Aged
multidisciplinary
Muscle, Skeletal - metabolism
Muscles
Muscular Diseases - genetics
Musculoskeletal system
Myogenesis
Non-coding RNA
Oxidative phosphorylation
Phosphorylation
Proteins
Regression analysis
Regression models
RNA Isoforms - genetics
RNA, Messenger - genetics
RNA, Untranslated - genetics
Science
Science (multidisciplinary)
Senescence
Skeletal muscle
Transcriptome
Transcriptomes
Young Adult
ISSN:2041-1723, 2041-1723
Online-Zugang:Volltext
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Abstract Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22–83 years old) of the GESTALT study of the National Institute on Aging–NIH. Expression levels of 57,205 protein-coding and non-coding RNAs were studied as a function of aging by linear and negative binomial regression models. From both models, 1134 RNAs changed significantly with age. The most differentially abundant mRNAs encoded proteins implicated in several age-related processes, including cellular senescence, insulin signaling, and myogenesis. Specific mRNA isoforms that changed significantly with age in skeletal muscle were enriched for proteins involved in oxidative phosphorylation and adipogenesis. Our study establishes a detailed framework of the global transcriptome and mRNA isoforms that govern muscle damage and homeostasis with age. As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during aging in healthy individuals.
AbstractList Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22-83 years old) of the GESTALT study of the National Institute on Aging-NIH. Expression levels of 57,205 protein-coding and non-coding RNAs were studied as a function of aging by linear and negative binomial regression models. From both models, 1134 RNAs changed significantly with age. The most differentially abundant mRNAs encoded proteins implicated in several age-related processes, including cellular senescence, insulin signaling, and myogenesis. Specific mRNA isoforms that changed significantly with age in skeletal muscle were enriched for proteins involved in oxidative phosphorylation and adipogenesis. Our study establishes a detailed framework of the global transcriptome and mRNA isoforms that govern muscle damage and homeostasis with age.Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22-83 years old) of the GESTALT study of the National Institute on Aging-NIH. Expression levels of 57,205 protein-coding and non-coding RNAs were studied as a function of aging by linear and negative binomial regression models. From both models, 1134 RNAs changed significantly with age. The most differentially abundant mRNAs encoded proteins implicated in several age-related processes, including cellular senescence, insulin signaling, and myogenesis. Specific mRNA isoforms that changed significantly with age in skeletal muscle were enriched for proteins involved in oxidative phosphorylation and adipogenesis. Our study establishes a detailed framework of the global transcriptome and mRNA isoforms that govern muscle damage and homeostasis with age.
As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during aging in healthy individuals.
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22–83 years old) of the GESTALT study of the National Institute on Aging–NIH. Expression levels of 57,205 protein-coding and non-coding RNAs were studied as a function of aging by linear and negative binomial regression models. From both models, 1134 RNAs changed significantly with age. The most differentially abundant mRNAs encoded proteins implicated in several age-related processes, including cellular senescence, insulin signaling, and myogenesis. Specific mRNA isoforms that changed significantly with age in skeletal muscle were enriched for proteins involved in oxidative phosphorylation and adipogenesis. Our study establishes a detailed framework of the global transcriptome and mRNA isoforms that govern muscle damage and homeostasis with age. As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during aging in healthy individuals.
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22–83 years old) of the GESTALT study of the National Institute on Aging–NIH. Expression levels of 57,205 protein-coding and non-coding RNAs were studied as a function of aging by linear and negative binomial regression models. From both models, 1134 RNAs changed significantly with age. The most differentially abundant mRNAs encoded proteins implicated in several age-related processes, including cellular senescence, insulin signaling, and myogenesis. Specific mRNA isoforms that changed significantly with age in skeletal muscle were enriched for proteins involved in oxidative phosphorylation and adipogenesis. Our study establishes a detailed framework of the global transcriptome and mRNA isoforms that govern muscle damage and homeostasis with age.As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during aging in healthy individuals.
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22–83 years old) of the GESTALT study of the National Institute on Aging–NIH. Expression levels of 57,205 protein-coding and non-coding RNAs were studied as a function of aging by linear and negative binomial regression models. From both models, 1134 RNAs changed significantly with age. The most differentially abundant mRNAs encoded proteins implicated in several age-related processes, including cellular senescence, insulin signaling, and myogenesis. Specific mRNA isoforms that changed significantly with age in skeletal muscle were enriched for proteins involved in oxidative phosphorylation and adipogenesis. Our study establishes a detailed framework of the global transcriptome and mRNA isoforms that govern muscle damage and homeostasis with age.
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve tissue integrity. To characterize these changes, RNA was extracted and sequenced from muscle biopsies collected from 53 healthy individuals (22–83 years old) of the GESTALT study of the National Institute on Aging–NIH. Expression levels of 57,205 protein-coding and non-coding RNAs were studied as a function of aging by linear and negative binomial regression models. From both models, 1134 RNAs changed significantly with age. The most differentially abundant mRNAs encoded proteins implicated in several age-related processes, including cellular senescence, insulin signaling, and myogenesis. Specific mRNA isoforms that changed significantly with age in skeletal muscle were enriched for proteins involved in oxidative phosphorylation and adipogenesis. Our study establishes a detailed framework of the global transcriptome and mRNA isoforms that govern muscle damage and homeostasis with age. As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during aging in healthy individuals.
ArticleNumber 2014
Author Harish, Abhinav
Ding, Jun
Yang, Jen-Hao
Gorospe, Myriam
Kaileh, Mary
Zukley, Linda M.
De, Supriyo
Tumasian, Robert A.
Wood, William H.
Kundu, Gautam
Coletta, Christopher
Piao, Yulan
Sen, Ranjan
Chia, Chee W.
Gonzalez-Freire, Marta
Lyashkov, Alexey
Ubaida-Mohien, Ceereena
Ferrucci, Luigi
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  organization: National Institute on Aging–Intramural Research Program, National Institutes of Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33795677$$D View this record in MEDLINE/PubMed
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Copyright This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021
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Copyright_xml – notice: This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021
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Snippet Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect accumulation of damage and compensatory adaptations to preserve...
As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present...
SourceID doaj
pubmedcentral
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StartPage 2014
SubjectTerms 38/39
38/88
38/91
631/337/2019
692/698/1671/1668/1973
82/80
Adaptation
Adipogenesis
Adult
Age
Aged
Aged, 80 and over
Aging
Damage accumulation
Female
Gene expression
Gene Expression Profiling
Healthy Aging - genetics
Homeostasis
Homeostasis - genetics
Humanities and Social Sciences
Humans
Insulin
Isoforms
Male
Middle Aged
multidisciplinary
Muscle, Skeletal - metabolism
Muscles
Muscular Diseases - genetics
Musculoskeletal system
Myogenesis
Non-coding RNA
Oxidative phosphorylation
Phosphorylation
Proteins
Regression analysis
Regression models
RNA Isoforms - genetics
RNA, Messenger - genetics
RNA, Untranslated - genetics
Science
Science (multidisciplinary)
Senescence
Skeletal muscle
Transcriptome
Transcriptomes
Young Adult
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Title Skeletal muscle transcriptome in healthy aging
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