Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features

The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of invasive lung ADC and its precursors by transcriptomic immune profiling, T cell receptor (TCR) sequencing and multiplex immunofluor...

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Vydáno v:	Nature communications Ročník 12; číslo 1; s. 2722 - 11
Hlavní autoři:	Dejima, Hitoshi, Hu, Xin, Chen, Runzhe, Zhang, Jiexin, Fujimoto, Junya, Parra, Edwin R., Haymaker, Cara, Hubert, Shawna M., Duose, Dzifa, Solis, Luisa M., Su, Dan, Fukuoka, Junya, Tabata, Kazuhiro, Pham, Hoa H. N., Mcgranahan, Nicholas, Zhang, Baili, Ye, Jie, Ying, Lisha, Little, Latasha, Gumbs, Curtis, Chow, Chi-Wan, Estecio, Marcos Roberto, Godoy, Myrna C. B., Antonoff, Mara B., Sepesi, Boris, Pass, Harvey I., Behrens, Carmen, Zhang, Jianhua, Vaporciyan, Ara A., Heymach, John V., Scheet, Paul, Lee, J. Jack, Wu, Jia, Futreal, P. Andrew, Reuben, Alexandre, Kadara, Humam, Wistuba, Ignacio I., Zhang, Jianjun
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 11.05.2021 Nature Publishing Group Nature Portfolio
Témata:	45/23 631/181/2474 631/250/580/1884/2323 631/67/1612/1350 692/4028/67/1612/1350 692/4028/67/580/1884/2323 Adenocarcinoma Carcinogenesis Carcinogens Copy number Cytotoxicity DNA methylation Down-regulation Epigenetics Evolution Humanities and Social Sciences Immune response Immune system Immunity Immunofluorescence Immunoregulation Immunosuppression Infiltration Lung cancer Lungs Lymphocytes Lymphocytes T Metastases multidisciplinary Mutation Precursors Preneoplasia Science Science (multidisciplinary) T cell receptors
ISSN:	2041-1723, 2041-1723
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