A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex

Klebsiella pneumoniae is a leading cause of antimicrobial-resistant (AMR) healthcare-associated infections, neonatal sepsis and community-acquired liver abscess, and is associated with chronic intestinal diseases. Its diversity and complex population structure pose challenges for analysis and interp...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 4188 - 16
Main Authors:	Lam, Margaret M. C., Wick, Ryan R., Watts, Stephen C., Cerdeira, Louise T., Wyres, Kelly L., Holt, Kathryn E.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.07.2021 Nature Publishing Group Nature Portfolio
Subjects:	45 45/23 631/114/1314 631/326/325/2482 631/326/41/2530 692/700/478/174 Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents Antimicrobial resistance Associated species Bacterial Proteins - genetics beta-Lactamases - genetics Carbapenemase Clinical isolates Cross Infection - diagnosis Cross Infection - drug therapy Cross Infection - epidemiology Cross Infection - microbiology Datasets as Topic Drug resistance Drug Resistance, Multiple, Bacterial - genetics Epidemiological Monitoring Epidemiology Gastrointestinal Microbiome - genetics Genome, Bacterial Genomes Genomics Genotyping Health surveillance Humanities and Social Sciences Humans Infant Infant, Newborn Interrogation Klebsiella Klebsiella Infections - diagnosis Klebsiella Infections - drug therapy Klebsiella Infections - epidemiology Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Klebsiella pneumoniae - pathogenicity Metagenome - genetics Molecular Epidemiology - methods Molecular Typing - methods multidisciplinary Mutation Neonates Phylogeny Population structure Public health Science Science (multidisciplinary) Sepsis Software Virulence Virulence - genetics Virulence Factors - genetics Whole Genome Sequencing
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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