Advances in the pathogenesis of psoriasis: from keratinocyte perspective

Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevan...

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Vydáno v:Cell death & disease Ročník 13; číslo 1; s. 81 - 13
Hlavní autoři: Zhou, Xue, Chen, Youdong, Cui, Lian, Shi, Yuling, Guo, Chunyuan
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 24.01.2022
Springer Nature B.V
Nature Publishing Group
Témata:
13/21
631/80/304
692/699/249
82/80
Antibodies
Antimicrobial peptides
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell signaling
Cytokines - metabolism
Dermatitis - metabolism
Humans
Hyperplasia
Immunology
Keratinocytes
Keratinocytes - metabolism
Life Sciences
Pathogenesis
Psoriasis
Psoriasis - metabolism
Review
Review Article
Signal Transduction
Skin diseases
Transcription factors
ISSN:2041-4889, 2041-4889
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Popis
Shrnutí:Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis.
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ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-022-04523-3