Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage

During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynam...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 1565 - 19
Main Authors:	Hurskainen, Maria, Mižíková, Ivana, Cook, David P., Andersson, Noora, Cyr-Depauw, Chanèle, Lesage, Flore, Helle, Emmi, Renesme, Laurent, Jankov, Robert P., Heikinheimo, Markku, Vanderhyden, Barbara C., Thébaud, Bernard
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.03.2021 Nature Publishing Group Nature Portfolio
Subjects:	13/1 13/31 14/32 14/63 49/91 631/1647/514 631/337 631/337/2019 631/80 631/80/304 64/60 Alveoli Animals Biological activity Bronchopulmonary Dysplasia - genetics Bronchopulmonary Dysplasia - pathology Crosstalk Dysplasia Endothelium Epithelium Fibroblasts Gas exchange Gene expression Gene sequencing Genotype Humanities and Social Sciences Hyperoxia Hyperoxia - genetics Hyperoxia - physiopathology Infants Inflammation Lung - metabolism Lung - pathology Lungs Macrophages Male Mice Microvasculature multidisciplinary Oxygen Phenotypes Populations Science Science (multidisciplinary) Sequence Analysis, RNA - methods Single-Cell Analysis - methods
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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