Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage

During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynam...

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Veröffentlicht in:Nature communications Jg. 12; H. 1; S. 1565 - 19
Hauptverfasser: Hurskainen, Maria, Mižíková, Ivana, Cook, David P., Andersson, Noora, Cyr-Depauw, Chanèle, Lesage, Flore, Helle, Emmi, Renesme, Laurent, Jankov, Robert P., Heikinheimo, Markku, Vanderhyden, Barbara C., Thébaud, Bernard
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 10.03.2021
Nature Publishing Group
Nature Portfolio
Schlagworte:
13/1
13/31
14/32
14/63
49/91
631/1647/514
631/337
631/337/2019
631/80
631/80/304
64/60
Alveoli
Animals
Biological activity
Bronchopulmonary Dysplasia - genetics
Bronchopulmonary Dysplasia - pathology
Crosstalk
Dysplasia
Endothelium
Epithelium
Fibroblasts
Gas exchange
Gene expression
Gene sequencing
Genotype
Humanities and Social Sciences
Hyperoxia
Hyperoxia - genetics
Hyperoxia - physiopathology
Infants
Inflammation
Lung - metabolism
Lung - pathology
Lungs
Macrophages
Male
Mice
Microvasculature
multidisciplinary
Oxygen
Phenotypes
Populations
Science
Science (multidisciplinary)
Sequence Analysis, RNA - methods
Single-Cell Analysis - methods
ISSN:2041-1723, 2041-1723
Online-Zugang:Volltext
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Abstract During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynamics during biological processes, such as development. Here, we use MULTI-seq to generate scRNA-seq profiles of over 66,000 cells from 36 mice during normal or impaired lung development secondary to hyperoxia with validation of some of the findings in lungs from BPD patients. We observe dynamic populations of cells, including several rare cell types and putative progenitors. Hyperoxia exposure, which mimics the BPD phenotype, alters the composition of all cellular compartments, particularly alveolar epithelium, stromal fibroblasts, capillary endothelium and macrophage populations. Pathway analysis and predicted dynamic cellular crosstalk suggest inflammatory signaling as the main driver of hyperoxia-induced changes. Our data provides a single-cell view of cellular changes associated with late lung development in health and disease. It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatures of impaired lung development under hyperoxia.
AbstractList During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynamics during biological processes, such as development. Here, we use MULTI-seq to generate scRNA-seq profiles of over 66,000 cells from 36 mice during normal or impaired lung development secondary to hyperoxia with validation of some of the findings in lungs from BPD patients. We observe dynamic populations of cells, including several rare cell types and putative progenitors. Hyperoxia exposure, which mimics the BPD phenotype, alters the composition of all cellular compartments, particularly alveolar epithelium, stromal fibroblasts, capillary endothelium and macrophage populations. Pathway analysis and predicted dynamic cellular crosstalk suggest inflammatory signaling as the main driver of hyperoxia-induced changes. Our data provides a single-cell view of cellular changes associated with late lung development in health and disease.It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatures of impaired lung development under hyperoxia.
During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynamics during biological processes, such as development. Here, we use MULTI-seq to generate scRNA-seq profiles of over 66,000 cells from 36 mice during normal or impaired lung development secondary to hyperoxia with validation of some of the findings in lungs from BPD patients. We observe dynamic populations of cells, including several rare cell types and putative progenitors. Hyperoxia exposure, which mimics the BPD phenotype, alters the composition of all cellular compartments, particularly alveolar epithelium, stromal fibroblasts, capillary endothelium and macrophage populations. Pathway analysis and predicted dynamic cellular crosstalk suggest inflammatory signaling as the main driver of hyperoxia-induced changes. Our data provides a single-cell view of cellular changes associated with late lung development in health and disease.
During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynamics during biological processes, such as development. Here, we use MULTI-seq to generate scRNA-seq profiles of over 66,000 cells from 36 mice during normal or impaired lung development secondary to hyperoxia with validation of some of the findings in lungs from BPD patients. We observe dynamic populations of cells, including several rare cell types and putative progenitors. Hyperoxia exposure, which mimics the BPD phenotype, alters the composition of all cellular compartments, particularly alveolar epithelium, stromal fibroblasts, capillary endothelium and macrophage populations. Pathway analysis and predicted dynamic cellular crosstalk suggest inflammatory signaling as the main driver of hyperoxia-induced changes. Our data provides a single-cell view of cellular changes associated with late lung development in health and disease. It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatures of impaired lung development under hyperoxia.
It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from MULTI-seq scRNAseq in mice showing exposure to higher oxygen levels affects cell fates, especially for alveolarisation, and define gene/cell signatures of impaired lung development under hyperoxia.
During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynamics during biological processes, such as development. Here, we use MULTI-seq to generate scRNA-seq profiles of over 66,000 cells from 36 mice during normal or impaired lung development secondary to hyperoxia with validation of some of the findings in lungs from BPD patients. We observe dynamic populations of cells, including several rare cell types and putative progenitors. Hyperoxia exposure, which mimics the BPD phenotype, alters the composition of all cellular compartments, particularly alveolar epithelium, stromal fibroblasts, capillary endothelium and macrophage populations. Pathway analysis and predicted dynamic cellular crosstalk suggest inflammatory signaling as the main driver of hyperoxia-induced changes. Our data provides a single-cell view of cellular changes associated with late lung development in health and disease.During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests as bronchopulmonary dysplasia (BPD) in preterm infants. Single-cell RNA sequencing (scRNA-seq) allows for assessment of complex cellular dynamics during biological processes, such as development. Here, we use MULTI-seq to generate scRNA-seq profiles of over 66,000 cells from 36 mice during normal or impaired lung development secondary to hyperoxia with validation of some of the findings in lungs from BPD patients. We observe dynamic populations of cells, including several rare cell types and putative progenitors. Hyperoxia exposure, which mimics the BPD phenotype, alters the composition of all cellular compartments, particularly alveolar epithelium, stromal fibroblasts, capillary endothelium and macrophage populations. Pathway analysis and predicted dynamic cellular crosstalk suggest inflammatory signaling as the main driver of hyperoxia-induced changes. Our data provides a single-cell view of cellular changes associated with late lung development in health and disease.
ArticleNumber 1565
Author Hurskainen, Maria
Cyr-Depauw, Chanèle
Heikinheimo, Markku
Mižíková, Ivana
Cook, David P.
Andersson, Noora
Jankov, Robert P.
Lesage, Flore
Vanderhyden, Barbara C.
Helle, Emmi
Renesme, Laurent
Thébaud, Bernard
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  surname: Hurskainen
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  organization: Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Division of Pediatric Cardiology, New Children’s Hospital, Helsinki University Hospital and University of Helsinki, Pediatric Research Center, New Children’s Hospital, University of Helsinki and Helsinki University Hospital, Department of Cellular and Molecular Medicine, University of Ottawa
– sequence: 2
  givenname: Ivana
  orcidid: 0000-0002-3440-9133
  surname: Mižíková
  fullname: Mižíková, Ivana
  organization: Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa
– sequence: 3
  givenname: David P.
  surname: Cook
  fullname: Cook, David P.
  organization: Department of Cellular and Molecular Medicine, University of Ottawa, Cancer Therapeutics Program, Ottawa Hospital Research Institute
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  givenname: Noora
  surname: Andersson
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  organization: Pediatric Research Center, New Children’s Hospital, University of Helsinki and Helsinki University Hospital, Research Programs unit, Systems Oncology, Faculty of Medicine, University of Helsinki
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  surname: Cyr-Depauw
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  organization: Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa
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  surname: Lesage
  fullname: Lesage, Flore
  organization: Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa
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  givenname: Emmi
  orcidid: 0000-0001-8993-2194
  surname: Helle
  fullname: Helle, Emmi
  organization: Division of Pediatric Cardiology, New Children’s Hospital, Helsinki University Hospital and University of Helsinki, Pediatric Research Center, New Children’s Hospital, University of Helsinki and Helsinki University Hospital, Research Programs Unit, Stem Cells and Metabolism, University of Helsinki
– sequence: 8
  givenname: Laurent
  orcidid: 0000-0001-6848-3617
  surname: Renesme
  fullname: Renesme, Laurent
  organization: Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa
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  givenname: Robert P.
  surname: Jankov
  fullname: Jankov, Robert P.
  organization: Department of Cellular and Molecular Medicine, University of Ottawa, Department of Pediatrics, Children’s Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, University of Ottawa, Molecular Biomedicine Program, Children’s Hospital of Eastern Ontario Research Institute
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  givenname: Markku
  orcidid: 0000-0001-9452-0661
  surname: Heikinheimo
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  organization: Pediatric Research Center, New Children’s Hospital, University of Helsinki and Helsinki University Hospital
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  givenname: Barbara C.
  orcidid: 0000-0002-7644-7189
  surname: Vanderhyden
  fullname: Vanderhyden, Barbara C.
  organization: Department of Cellular and Molecular Medicine, University of Ottawa, Cancer Therapeutics Program, Ottawa Hospital Research Institute, Department of Obstetrics and Gynecology, University of Ottawa/The Ottawa Hospital
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  givenname: Bernard
  orcidid: 0000-0003-1844-7145
  surname: Thébaud
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  email: bthebaud@toh.ca
  organization: Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Department of Pediatrics, Children’s Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, University of Ottawa
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33692365$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/s41572-019-0127-7
10.1172/jci.insight.122490
10.1038/s41598-020-61919-x
10.3109/01902149809099588
10.1242/dmm.027086
10.1038/s41467-018-07770-1
10.1165/rcmb.2012-0407OC
10.1161/CIRCULATIONAHA.105.541524
10.1016/j.clp.2015.08.002
10.3389/fimmu.2017.00623
10.1152/ajplung.00343.2017
10.1164/rccm.201705-0925OC
10.1038/s41598-018-28190-7
10.1073/pnas.1717802115
10.1159/000458465
10.1016/j.celrep.2018.03.010
10.1016/0092-8674(93)90499-G
10.1371/journal.pone.0052886
10.1172/jci.insight.126556
10.1007/s00441-016-2554-z
10.1038/s41586-020-2922-4
10.3389/fimmu.2019.01084
10.1152/ajplung.00139.2017
10.3389/fmed.2015.00091
10.1161/CIRCULATIONAHA.114.009124
10.1164/rccm.200909-1361OC
10.1038/s41592-019-0433-8
10.1038/s41390-019-0335-6
10.1038/s41586-020-2822-7
10.1542/neo.20-5-e272
10.1016/j.stem.2018.01.010
10.1165/rcmb.2010-0058OC
10.4049/jimmunol.1001539
10.1186/s13059-019-1874-1
10.1016/j.cell.2017.07.034
10.1371/journal.pbio.3000557
10.1074/jbc.M507515200
10.1038/s41591-018-0096-5
10.1136/fn.77.3.F198
10.1152/ajplung.00527.2017
10.15252/emmm.201809448
10.1111/jmi.12800
10.1002/path.5076
10.1126/science.aal3321
10.1186/s12931-014-0162-6
10.1053/j.semperi.2015.09.004
10.1152/ajplung.00145.2015
10.1016/S0022-3476(05)81201-6
10.1016/j.immuni.2019.03.009
10.1093/nar/gky900
10.1016/j.resp.2015.09.008
10.18632/oncotarget.14722
10.4049/jimmunol.1500906
10.1038/s41467-019-08831-9
10.1016/j.ajpath.2016.07.004
10.1164/rccm.200611-1660PP
10.1164/rccm.201812-2312OC
10.4049/jimmunol.180.1.601
10.1038/s41598-018-35256-z
10.1038/ncomms9977
10.1038/nbt.4096
10.1165/rcmb.2003-0049OC
10.1152/ajplung.1993.265.6.L627
10.1016/j.cels.2015.12.004
10.1016/j.cell.2018.09.009
10.1183/09031936.00127107
10.1371/journal.pone.0009674
10.1164/rccm.201712-2410OC
10.1165/ajrcmb.24.2.3993
10.1242/dev.129122
10.3389/fphys.2018.00138
10.1186/s12967-019-1843-1
10.1242/dev.176354
10.1016/j.devcel.2020.01.009
10.1165/rcmb.2016-0361OC
10.1378/chest.125.2.754
10.1002/jcp.24156
10.1165/ajrcmb.24.6.4355
10.1080/14712598.2019.1596256
10.7554/eLife.53072
10.1038/s41592-019-0667-5
10.1038/pr.2015.46
10.1073/pnas.0506580102
10.1203/01.pdr.0000185269.93228.29
10.1165/rcmb.2010-0158OC
10.1038/cr.2016.85
10.1016/j.earlhumdev.2012.12.011
10.1126/sciadv.aaw3851
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References Wakabayashi (CR63) 2018; 22
McGinnis (CR8) 2019; 16
Surate Solaligue, Rodríguez-Castillo, Ahlbrecht, Morty (CR7) 2017; 313
D’angio, Johnston, Wright, Reed, Finkelstein (CR80) 1998; 24
Beers, Mulugeta (CR19) 2017; 367
Wong (CR77) 2008; 32
Thébaud (CR6) 2019; 5
Pryhuber (CR79) 2015; 42
Visser, de, Walther, Laghmani, van der Laarse, Wagenaar (CR59) 2010; 182
Zilionis (CR66) 2019; 50
Vila Ellis (CR47) 2020; 52
Thébaud (CR75) 2005; 112
Ardini-Poleske (CR9) 2017; 313
Jia (CR38) 2013; 228
Gremlich (CR42) 2020; 10
Reyfman (CR73) 2019; 199
CR74
Subramanian (CR89) 2005; 102
Inoue (CR17) 2013; 89
Thul (CR11) 2017; 356
Travaglini (CR37) 2020; 587
Ren (CR62) 2019; 200
Harijith (CR82) 2011; 44
Butler, Hoffman, Smibert, Papalexi, Satija (CR86) 2018; 36
Nardiello (CR84) 2017; 10
Li (CR39) 2019; 21
Bottoms, Howell, Reinhardt, Evans, McAnulty (CR55) 2010; 5
Dzhuraev (CR85) 2019; 275
Gokey (CR18) 2018; 3
Perveen (CR16) 2019; 85
Thébaud, Abman (CR56) 2007; 175
Browaeys, Saelens, Saeys (CR12) 2020; 17
Kalymbetova (CR69) 2018; 245
Zhong (CR23) 2018; 315
Liberzon (CR88) 2015; 1
Barron, Gharib, Duffield (CR28) 2016; 186
Orecchioni, Ghosheh, Pramod, Ley (CR71) 2019; 10
McQualter (CR36) 2019; 19
Gibbings (CR68) 2017; 57
Liao (CR78) 2015; 6
Olave (CR43) 2016; 310
Hafemeister, Satija (CR87) 2019; 20
Lambrechts (CR27) 2018; 24
Willis (CR70) 2018; 197
Marino (CR14) 2011; 186
Angelidis (CR35) 2019; 10
Alphonse (CR61) 2014; 129
Mižíková, Morty (CR41) 2015; 2
O’Reilly (CR57) 2001; 24
Stouch (CR81) 2016; 196
White, Wojcik, Gruenert, Sun, Dorscheid (CR25) 2001; 24
Wujak (CR52) 2016; 220
Revenis, Kaliner (CR13) 1992; 121
Niethamer (CR48) 2020; 9
Mould, Jackson, Henson, Seibold, Janssen (CR65) 2019; 4
Guo (CR1) 2019; 10
Leong (CR4) 2019; 20
Wilson, Bachurski, Ikegami, Jobe, Kallapur (CR30) 2005; 58
Wang (CR45) 2018; 8
Windt, van der, Schouten, Zeerleder, Florquin, van der Poll (CR40) 2011; 44
Li (CR33) 2019; 146
Ruiz‐Camp (CR32) 2019; 11
Fleming, Crouch, Ruzicka, Sly (CR44) 1993; 265
Zepp (CR21) 2017; 170
Chen, Krasnow (CR26) 2012; 7
Yang (CR72) 2017; 8
Kevill (CR15) 2008; 180
Gillich (CR46) 2020; 586
Bartram, Speer (CR51) 2004; 125
Jónsson, Tullus, Brauner, Lu, Noack (CR22) 1997; 77
Xie (CR29) 2018; 22
Lim (CR49) 2015; 77
Cheong (CR20) 2006; 281
Djurec (CR31) 2018; 115
McGrath-Morrow, Cho, Soutiere, Mitzner, Tuder (CR58) 2004; 30
Greco (CR76) 2019; 17
Hiepen (CR60) 2019; 17
Tan, Krasnow (CR67) 2016; 143
Warburton (CR3) 2017; 111
Brazee (CR53) 2017; 8
Pi (CR54) 2018; 9
Lal, Ambalavanan (CR5) 2015; 39
Joza, Wang, Tseu, Ackerley, Post (CR24) 2013; 49
Yu, Song, Wang, Zeng (CR64) 2016; 26
Fulton, Cui, Goldsmith, Bermick, Popova (CR34) 2018; 8
Cohen (CR2) 2018; 175
Zhang (CR10) 2019; 47
Sureshbabu (CR83) 2015; 16
Harper (CR50) 1993; 75
JA Zepp (21865_CR21) 2017; 170
T Xie (21865_CR29) 2018; 22
L Vila Ellis (21865_CR47) 2020; 52
MM Wang (21865_CR45) 2018; 8
SA McGrath-Morrow (21865_CR58) 2004; 30
PJ Thul (21865_CR11) 2017; 356
W Harper (21865_CR50) 1993; 75
SE Bottoms (21865_CR55) 2010; 5
F Greco (21865_CR76) 2019; 17
CV Lal (21865_CR5) 2015; 39
KA Kevill (21865_CR15) 2008; 180
MA O’Reilly (21865_CR57) 2001; 24
JL McQualter (21865_CR36) 2019; 19
PA Reyfman (21865_CR73) 2019; 199
M Guo (21865_CR1) 2019; 10
I Angelidis (21865_CR35) 2019; 10
R Lim (21865_CR49) 2015; 77
N Cheong (21865_CR20) 2006; 281
ME Ardini-Poleske (21865_CR9) 2017; 313
U Bartram (21865_CR51) 2004; 125
A Liberzon (21865_CR88) 2015; 1
CT D’angio (21865_CR80) 1998; 24
X Zhang (21865_CR10) 2019; 47
21865_CR74
CS McGinnis (21865_CR8) 2019; 16
TC Wilson (21865_CR30) 2005; 58
R Zilionis (21865_CR66) 2019; 50
R Marino (21865_CR14) 2011; 186
L Barron (21865_CR28) 2016; 186
B Thébaud (21865_CR56) 2007; 175
M Li (21865_CR39) 2019; 21
N Olave (21865_CR43) 2016; 310
B Thébaud (21865_CR75) 2005; 112
AN Stouch (21865_CR81) 2016; 196
PM Wong (21865_CR77) 2008; 32
S Joza (21865_CR24) 2013; 49
I Mižíková (21865_CR41) 2015; 2
B Jónsson (21865_CR22) 1997; 77
M Yang (21865_CR72) 2017; 8
B Thébaud (21865_CR6) 2019; 5
Y Zhong (21865_CR23) 2018; 315
C Hiepen (21865_CR60) 2019; 17
ŁA Wujak (21865_CR52) 2016; 220
M Orecchioni (21865_CR71) 2019; 10
MF Beers (21865_CR19) 2017; 367
M Leong (21865_CR4) 2019; 20
KJ Travaglini (21865_CR37) 2020; 587
TV Kalymbetova (21865_CR69) 2018; 245
S Gremlich (21865_CR42) 2020; 10
M Djurec (21865_CR31) 2018; 115
J Ruiz‐Camp (21865_CR32) 2019; 11
M Cohen (21865_CR2) 2018; 175
H Inoue (21865_CR17) 2013; 89
R Browaeys (21865_CR12) 2020; 17
SYS Tan (21865_CR67) 2016; 143
A Gillich (21865_CR46) 2020; 586
X Ren (21865_CR62) 2019; 200
SL Gibbings (21865_CR68) 2017; 57
YP Visser (21865_CR59) 2010; 182
TK Niethamer (21865_CR48) 2020; 9
CT Fulton (21865_CR34) 2018; 8
RS Alphonse (21865_CR61) 2014; 129
QC Yu (21865_CR64) 2016; 26
J Chen (21865_CR26) 2012; 7
C Li (21865_CR33) 2019; 146
PL Brazee (21865_CR53) 2017; 8
DE Surate Solaligue (21865_CR7) 2017; 313
A Butler (21865_CR86) 2018; 36
S Perveen (21865_CR16) 2019; 85
GJW Windt (21865_CR40) 2011; 44
A Subramanian (21865_CR89) 2005; 102
C Hafemeister (21865_CR87) 2019; 20
A Sureshbabu (21865_CR83) 2015; 16
JJ Gokey (21865_CR18) 2018; 3
L Pi (21865_CR54) 2018; 9
T Wakabayashi (21865_CR63) 2018; 22
D Lambrechts (21865_CR27) 2018; 24
J Liao (21865_CR78) 2015; 6
C Nardiello (21865_CR84) 2017; 10
Y Jia (21865_CR38) 2013; 228
ME Revenis (21865_CR13) 1992; 121
SR White (21865_CR25) 2001; 24
RE Fleming (21865_CR44) 1993; 265
A Harijith (21865_CR82) 2011; 44
D Warburton (21865_CR3) 2017; 111
G Dzhuraev (21865_CR85) 2019; 275
KJ Mould (21865_CR65) 2019; 4
GR Willis (21865_CR70) 2018; 197
GS Pryhuber (21865_CR79) 2015; 42
References_xml – volume: 5
  start-page: 78
  year: 2019
  ident: CR6
  article-title: Bronchopulmonary dysplasia
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/s41572-019-0127-7
– volume: 3
  start-page: e122490
  year: 2018
  ident: CR18
  article-title: MEG3 is increased in idiopathic pulmonary fibrosis and regulates epithelial cell differentiation
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.122490
– volume: 10
  year: 2020
  ident: CR42
  article-title: Tenascin-C inactivation impacts lung structure and function beyond lung development
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-61919-x
– volume: 24
  start-page: 685
  year: 1998
  end-page: 702
  ident: CR80
  article-title: Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxia
  publication-title: Exp. Lung Res.
  doi: 10.3109/01902149809099588
– volume: 10
  start-page: 185
  year: 2017
  end-page: 196
  ident: CR84
  article-title: Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia
  publication-title: Dis. Model. Mech.
  doi: 10.1242/dmm.027086
– volume: 10
  year: 2019
  ident: CR1
  article-title: Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07770-1
– volume: 49
  start-page: 627
  year: 2013
  end-page: 636
  ident: CR24
  article-title: Fetal, but not postnatal, deletion of semaphorin-neuropilin-1 signaling affects murine alveolar development
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2012-0407OC
– ident: CR74
– volume: 112
  start-page: 2477
  year: 2005
  end-page: 2486
  ident: CR75
  article-title: Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.541524
– volume: 42
  start-page: 697
  year: 2015
  end-page: 718
  ident: CR79
  article-title: Postnatal infections and immunology affecting chronic lung disease of prematurity
  publication-title: Clin. Perinatol.
  doi: 10.1016/j.clp.2015.08.002
– volume: 8
  start-page: 623
  year: 2017
  ident: CR53
  article-title: FXYD5 is an essential mediator of the inflammatory response during lung injury
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.00623
– volume: 313
  start-page: L1101
  year: 2017
  end-page: L1153
  ident: CR7
  article-title: Recent advances in our understanding of the mechanisms of late lung development and bronchopulmonary dysplasia
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00343.2017
– volume: 197
  start-page: 104
  year: 2018
  end-page: 116
  ident: CR70
  article-title: Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201705-0925OC
– volume: 8
  year: 2018
  ident: CR45
  article-title: Expression of periaxin (PRX) specifically in the human cerebrovascular system: PDZ domain-mediated strengthening of endothelial barrier function
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-28190-7
– volume: 115
  start-page: E1147
  year: 2018
  end-page: E1156
  ident: CR31
  article-title: Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.1717802115
– volume: 111
  start-page: 398
  year: 2017
  end-page: 401
  ident: CR3
  article-title: Overview of lung development in the newborn human
  publication-title: Neonatology
  doi: 10.1159/000458465
– volume: 22
  start-page: 3625
  year: 2018
  end-page: 3640
  ident: CR29
  article-title: Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.03.010
– volume: 75
  start-page: 805
  year: 1993
  end-page: 816
  ident: CR50
  article-title: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90499-G
– volume: 7
  start-page: e52886
  year: 2012
  ident: CR26
  article-title: Integrin beta 1 suppresses multilayering of a simple epithelium
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0052886
– volume: 4
  start-page: e126556
  year: 2019
  ident: CR65
  article-title: Single cell RNA sequencing identifies unique inflammatory airspace macrophage subsets
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.126556
– volume: 367
  start-page: 481
  year: 2017
  end-page: 493
  ident: CR19
  article-title: The biology of the ABCA3 lipid transporter in lung health and disease
  publication-title: Cell Tissue Res.
  doi: 10.1007/s00441-016-2554-z
– volume: 587
  start-page: 619
  year: 2020
  end-page: 625
  ident: CR37
  article-title: A molecular cell atlas of the human lung from single-cell RNA sequencing
  publication-title: Nature
  doi: 10.1038/s41586-020-2922-4
– volume: 10
  start-page: 1084
  year: 2019
  ident: CR71
  article-title: Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS–) vs. alternatively activated macrophages
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.01084
– volume: 313
  start-page: L733
  year: 2017
  end-page: L740
  ident: CR9
  article-title: LungMAP: the molecular atlas of lung development program
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00139.2017
– volume: 21
  start-page: 607
  year: 2019
  end-page: 614
  ident: CR39
  article-title: Inhibition of calcineurin/NFATc4 signaling attenuates ventilator‑induced lung injury
  publication-title: Mol. Med. Rep.
– volume: 2
  start-page: 91
  year: 2015
  ident: CR41
  article-title: The extracellular matrix in bronchopulmonary dysplasia: target and source
  publication-title: Front. Med.
  doi: 10.3389/fmed.2015.00091
– volume: 129
  start-page: 2144
  year: 2014
  end-page: 2157
  ident: CR61
  article-title: Existence, functional impairment, and lung repair potential of endothelial colony-forming cells in oxygen-induced arrested alveolar growth
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.114.009124
– volume: 182
  start-page: 1239
  year: 2010
  end-page: 1250
  ident: CR59
  article-title: Apelin attenuates hyperoxic lung and heart injury in neonatal rats
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200909-1361OC
– volume: 16
  start-page: 619
  year: 2019
  end-page: 626
  ident: CR8
  article-title: MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices
  publication-title: Nat. Methods
  doi: 10.1038/s41592-019-0433-8
– volume: 85
  start-page: 711
  year: 2019
  end-page: 718
  ident: CR16
  article-title: MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia
  publication-title: Pediatr. Res.
  doi: 10.1038/s41390-019-0335-6
– volume: 586
  start-page: 785
  year: 2020
  end-page: 789
  ident: CR46
  article-title: Capillary cell-type specialization in the alveolus
  publication-title: Nature
  doi: 10.1038/s41586-020-2822-7
– volume: 20
  start-page: e272
  year: 2019
  end-page: e279
  ident: CR4
  article-title: Genetic approaches to bronchopulmonary dysplasia
  publication-title: NeoRev.
  doi: 10.1542/neo.20-5-e272
– volume: 22
  start-page: 384
  year: 2018
  end-page: 397
  ident: CR63
  article-title: CD157 marks tissue-resident endothelial stem cells with homeostatic and regenerative properties
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.01.010
– volume: 44
  start-page: 621
  year: 2011
  end-page: 630
  ident: CR82
  article-title: A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2010-0058OC
– volume: 186
  start-page: 4433
  year: 2011
  end-page: 4442
  ident: CR14
  article-title: Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1001539
– volume: 20
  year: 2019
  ident: CR87
  article-title: Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1874-1
– volume: 170
  start-page: 1134
  year: 2017
  end-page: 1148
  ident: CR21
  article-title: Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung
  publication-title: Cell
  doi: 10.1016/j.cell.2017.07.034
– volume: 17
  start-page: e3000557
  year: 2019
  ident: CR60
  article-title: BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics
  publication-title: PLOS Biol.
  doi: 10.1371/journal.pbio.3000557
– volume: 281
  start-page: 9791
  year: 2006
  end-page: 9800
  ident: CR20
  article-title: Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M507515200
– volume: 24
  start-page: 1277
  year: 2018
  end-page: 1289
  ident: CR27
  article-title: Phenotype molding of stromal cells in the lung tumor microenvironment
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0096-5
– volume: 77
  start-page: F198
  year: 1997
  end-page: F201
  ident: CR22
  article-title: Early increase of TNFalpha and IL-6 in tracheobronchial aspirate fluid indicator of subsequent chronic lung disease in preterm infants
  publication-title: Arch. Dis. Child. - Fetal Neonatal Ed.
  doi: 10.1136/fn.77.3.F198
– volume: 315
  start-page: L116
  year: 2018
  end-page: L132
  ident: CR23
  article-title: Maternal omega-3 PUFA supplementation prevents hyperoxia-induced pulmonary hypertension in the offspring
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00527.2017
– volume: 11
  start-page: e9448
  year: 2019
  ident: CR32
  article-title: Targeting miR‐34a/ Pdgfra interactions partially corrects alveologenesis in experimental bronchopulmonary dysplasia
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201809448
– volume: 275
  start-page: 36
  year: 2019
  end-page: 50
  ident: CR85
  article-title: Estimation of absolute number of alveolar epithelial type 2 cells in mouse lungs: a comparison between stereology and flow cytometry
  publication-title: J. Microsc.
  doi: 10.1111/jmi.12800
– volume: 245
  start-page: 153
  year: 2018
  end-page: 159
  ident: CR69
  article-title: Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia: Macrophages mediate aberrant lung alveolarization
  publication-title: J. Pathol.
  doi: 10.1002/path.5076
– volume: 356
  start-page: eaal3321
  year: 2017
  ident: CR11
  article-title: A subcellular map of the human proteome
  publication-title: Science
  doi: 10.1126/science.aal3321
– volume: 16
  start-page: 4
  year: 2015
  ident: CR83
  article-title: Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung
  publication-title: Respir. Res.
  doi: 10.1186/s12931-014-0162-6
– volume: 39
  start-page: 584
  year: 2015
  end-page: 591
  ident: CR5
  article-title: Genetic predisposition to bronchopulmonary dysplasia
  publication-title: Semin. Perinatol.
  doi: 10.1053/j.semperi.2015.09.004
– volume: 310
  start-page: L476
  year: 2016
  end-page: L487
  ident: CR43
  article-title: Regulation of alveolar septation by microRNA-489
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00145.2015
– volume: 121
  start-page: 262
  year: 1992
  end-page: 270
  ident: CR13
  article-title: Lactoferrin and lysozyme deficiency in airway secretions: Association with the development of bronchopulmonary dysplasia
  publication-title: J. Pediatr.
  doi: 10.1016/S0022-3476(05)81201-6
– volume: 50
  start-page: 1317
  year: 2019
  end-page: 1334
  ident: CR66
  article-title: Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.009
– volume: 47
  start-page: D721
  year: 2019
  end-page: D728
  ident: CR10
  article-title: CellMarker: a manually curated resource of cell markers in human and mouse
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky900
– volume: 220
  start-page: 54
  year: 2016
  end-page: 61
  ident: CR52
  article-title: FXYD1 negatively regulates Na+/K+-ATPase activity in lung alveolar epithelial cells
  publication-title: Respir. Physiol. Neurobiol.
  doi: 10.1016/j.resp.2015.09.008
– volume: 8
  start-page: 18670
  year: 2017
  end-page: 18679
  ident: CR72
  article-title: Angiogenesis-related genes may be a more important factor than matrix metalloproteinases in bronchopulmonary dysplasia development
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.14722
– volume: 196
  start-page: 3411
  year: 2016
  end-page: 3420
  ident: CR81
  article-title: IL-1β and inflammasome activity link inflammation to abnormal fetal airway development
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1500906
– volume: 10
  year: 2019
  ident: CR35
  article-title: An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08831-9
– volume: 186
  start-page: 2519
  year: 2016
  end-page: 2531
  ident: CR28
  article-title: Lung pericytes and resident fibroblasts
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2016.07.004
– volume: 175
  start-page: 978
  year: 2007
  end-page: 985
  ident: CR56
  article-title: Bronchopulmonary dysplasia: where have all the vessels gone? Roles of angiogenic growth factors in chronic lung disease
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200611-1660PP
– volume: 200
  start-page: 1164
  year: 2019
  end-page: 1176
  ident: CR62
  article-title: Postnatal alveologenesis depends on FOXF1 signaling in c-KIT + endothelial progenitor cells
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201812-2312OC
– volume: 180
  start-page: 601
  year: 2008
  end-page: 608
  ident: CR15
  article-title: A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.180.1.601
– volume: 8
  year: 2018
  ident: CR34
  article-title: Gene expression signatures point to a male sex-specific lung mesenchymal cell PDGF receptor signaling defect in infants developing bronchopulmonary dysplasia
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-35256-z
– volume: 6
  year: 2015
  ident: CR78
  article-title: The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9977
– volume: 36
  start-page: 411
  year: 2018
  end-page: 420
  ident: CR86
  article-title: Integrating single-cell transcriptomic data across different conditions, technologies, and species
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4096
– volume: 30
  start-page: 635
  year: 2004
  end-page: 640
  ident: CR58
  article-title: The effect of neonatal hyperoxia on the lung of p21 Waf1/Cip1/Sdi1 -deficient mice
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2003-0049OC
– volume: 265
  start-page: L627
  year: 1993
  end-page: L635
  ident: CR44
  article-title: Pulmonary carbonic anhydrase IV: developmental regulation and cell-specific expression in the capillary endothelium
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.1993.265.6.L627
– volume: 1
  start-page: 417
  year: 2015
  end-page: 425
  ident: CR88
  article-title: The molecular signatures database hallmark gene set collection
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2015.12.004
– volume: 175
  start-page: 1031
  year: 2018
  end-page: 1044
  ident: CR2
  article-title: Lung single-cell signaling interaction map reveals basophil role in macrophage imprinting
  publication-title: Cell
  doi: 10.1016/j.cell.2018.09.009
– volume: 32
  start-page: 321
  year: 2008
  end-page: 328
  ident: CR77
  article-title: Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.00127107
– volume: 5
  start-page: e9674
  year: 2010
  ident: CR55
  article-title: TGF-β isoform specific regulation of airway inflammation and remodelling in a murine model of asthma
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0009674
– volume: 199
  start-page: 1517
  year: 2019
  end-page: 1536
  ident: CR73
  article-title: Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201712-2410OC
– volume: 24
  start-page: 179
  year: 2001
  end-page: 186
  ident: CR25
  article-title: Airway epithelial cell wound repair mediated by α-dystroglycan
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/ajrcmb.24.2.3993
– volume: 143
  start-page: 1318
  year: 2016
  end-page: 1327
  ident: CR67
  article-title: Developmental origin of lung macrophage diversity
  publication-title: Development
  doi: 10.1242/dev.129122
– volume: 9
  start-page: 138
  year: 2018
  ident: CR54
  article-title: Vascular endothelial cell-specific connective tissue growth factor (CTGF) is necessary for development of chronic hypoxia-induced pulmonary hypertension
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2018.00138
– volume: 17
  year: 2019
  ident: CR76
  article-title: Hyperoxia-induced lung structure–function relation, vessel rarefaction, and cardiac hypertrophy in an infant rat model
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-019-1843-1
– volume: 146
  start-page: dev176354
  year: 2019
  ident: CR33
  article-title: Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis
  publication-title: Development
  doi: 10.1242/dev.176354
– volume: 52
  start-page: 617
  year: 2020
  end-page: 630
  ident: CR47
  article-title: Epithelial vegfa specifies a distinct endothelial population in the mouse lung
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2020.01.009
– volume: 57
  start-page: 66
  year: 2017
  end-page: 76
  ident: CR68
  article-title: Three unique interstitial macrophages in the murine lung at steady state
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2016-0361OC
– volume: 125
  start-page: 754
  year: 2004
  end-page: 765
  ident: CR51
  article-title: The role of transforming growth factor β in lung development and disease
  publication-title: Chest
  doi: 10.1378/chest.125.2.754
– volume: 228
  start-page: 476
  year: 2013
  end-page: 484
  ident: CR38
  article-title: Regulation of lung fibroblast activation by annexin A1
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.24156
– volume: 24
  start-page: 703
  year: 2001
  end-page: 710
  ident: CR57
  article-title: The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/ajrcmb.24.6.4355
– volume: 19
  start-page: 539
  year: 2019
  end-page: 546
  ident: CR36
  article-title: Endogenous lung stem cells for lung regeneration
  publication-title: Expert Opin. Biol. Ther.
  doi: 10.1080/14712598.2019.1596256
– volume: 9
  start-page: e53072
  year: 2020
  ident: CR48
  article-title: Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury
  publication-title: eLife
  doi: 10.7554/eLife.53072
– volume: 17
  start-page: 159
  year: 2020
  end-page: 162
  ident: CR12
  article-title: NicheNet: modeling intercellular communication by linking ligands to target genes
  publication-title: Nat. Methods
  doi: 10.1038/s41592-019-0667-5
– volume: 77
  start-page: 749
  year: 2015
  end-page: 756
  ident: CR49
  article-title: Activin A contributes to the development of hyperoxia-induced lung injury in neonatal mice
  publication-title: Pediatr. Res.
  doi: 10.1038/pr.2015.46
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 15550
  ident: CR89
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.0506580102
– volume: 58
  start-page: 1204
  year: 2005
  end-page: 1209
  ident: CR30
  article-title: Pulmonary and systemic induction of SAA3 after ventilation and endotoxin in preterm lambs
  publication-title: Pediatr. Res.
  doi: 10.1203/01.pdr.0000185269.93228.29
– volume: 44
  start-page: 377
  year: 2011
  end-page: 383
  ident: CR40
  article-title: CD44 is protective during hyperoxia-induced lung injury
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2010-0158OC
– volume: 26
  start-page: 1079
  year: 2016
  end-page: 1098
  ident: CR64
  article-title: Identification of blood vascular endothelial stem cells by the expression of protein C receptor
  publication-title: Cell Res.
  doi: 10.1038/cr.2016.85
– volume: 89
  start-page: 425
  year: 2013
  end-page: 429
  ident: CR17
  article-title: Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants
  publication-title: Early Hum. Dev.
  doi: 10.1016/j.earlhumdev.2012.12.011
– volume: 57
  start-page: 66
  year: 2017
  ident: 21865_CR68
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2016-0361OC
– volume: 16
  start-page: 4
  year: 2015
  ident: 21865_CR83
  publication-title: Respir. Res.
  doi: 10.1186/s12931-014-0162-6
– volume: 22
  start-page: 384
  year: 2018
  ident: 21865_CR63
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2018.01.010
– volume: 85
  start-page: 711
  year: 2019
  ident: 21865_CR16
  publication-title: Pediatr. Res.
  doi: 10.1038/s41390-019-0335-6
– volume: 24
  start-page: 703
  year: 2001
  ident: 21865_CR57
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/ajrcmb.24.6.4355
– volume: 356
  start-page: eaal3321
  year: 2017
  ident: 21865_CR11
  publication-title: Science
  doi: 10.1126/science.aal3321
– volume: 310
  start-page: L476
  year: 2016
  ident: 21865_CR43
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00145.2015
– volume: 10
  start-page: 185
  year: 2017
  ident: 21865_CR84
  publication-title: Dis. Model. Mech.
  doi: 10.1242/dmm.027086
– volume: 36
  start-page: 411
  year: 2018
  ident: 21865_CR86
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.4096
– volume: 24
  start-page: 1277
  year: 2018
  ident: 21865_CR27
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0096-5
– volume: 275
  start-page: 36
  year: 2019
  ident: 21865_CR85
  publication-title: J. Microsc.
  doi: 10.1111/jmi.12800
– volume: 281
  start-page: 9791
  year: 2006
  ident: 21865_CR20
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M507515200
– volume: 32
  start-page: 321
  year: 2008
  ident: 21865_CR77
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.00127107
– volume: 5
  start-page: e9674
  year: 2010
  ident: 21865_CR55
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0009674
– volume: 186
  start-page: 4433
  year: 2011
  ident: 21865_CR14
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1001539
– volume: 75
  start-page: 805
  year: 1993
  ident: 21865_CR50
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90499-G
– volume: 39
  start-page: 584
  year: 2015
  ident: 21865_CR5
  publication-title: Semin. Perinatol.
  doi: 10.1053/j.semperi.2015.09.004
– volume: 9
  start-page: e53072
  year: 2020
  ident: 21865_CR48
  publication-title: eLife
  doi: 10.7554/eLife.53072
– volume: 77
  start-page: F198
  year: 1997
  ident: 21865_CR22
  publication-title: Arch. Dis. Child. - Fetal Neonatal Ed.
  doi: 10.1136/fn.77.3.F198
– volume: 125
  start-page: 754
  year: 2004
  ident: 21865_CR51
  publication-title: Chest
  doi: 10.1378/chest.125.2.754
– volume: 111
  start-page: 398
  year: 2017
  ident: 21865_CR3
  publication-title: Neonatology
  doi: 10.1159/000458465
– volume: 180
  start-page: 601
  year: 2008
  ident: 21865_CR15
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.180.1.601
– volume: 89
  start-page: 425
  year: 2013
  ident: 21865_CR17
  publication-title: Early Hum. Dev.
  doi: 10.1016/j.earlhumdev.2012.12.011
– volume: 143
  start-page: 1318
  year: 2016
  ident: 21865_CR67
  publication-title: Development
  doi: 10.1242/dev.129122
– volume: 10
  year: 2020
  ident: 21865_CR42
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-61919-x
– volume: 313
  start-page: L1101
  year: 2017
  ident: 21865_CR7
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00343.2017
– volume: 220
  start-page: 54
  year: 2016
  ident: 21865_CR52
  publication-title: Respir. Physiol. Neurobiol.
  doi: 10.1016/j.resp.2015.09.008
– volume: 5
  start-page: 78
  year: 2019
  ident: 21865_CR6
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/s41572-019-0127-7
– volume: 197
  start-page: 104
  year: 2018
  ident: 21865_CR70
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201705-0925OC
– volume: 11
  start-page: e9448
  year: 2019
  ident: 21865_CR32
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201809448
– volume: 102
  start-page: 15545
  year: 2005
  ident: 21865_CR89
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.0506580102
– volume: 21
  start-page: 607
  year: 2019
  ident: 21865_CR39
  publication-title: Mol. Med. Rep.
– volume: 47
  start-page: D721
  year: 2019
  ident: 21865_CR10
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky900
– volume: 8
  year: 2018
  ident: 21865_CR34
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-35256-z
– volume: 42
  start-page: 697
  year: 2015
  ident: 21865_CR79
  publication-title: Clin. Perinatol.
  doi: 10.1016/j.clp.2015.08.002
– volume: 112
  start-page: 2477
  year: 2005
  ident: 21865_CR75
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.541524
– volume: 24
  start-page: 685
  year: 1998
  ident: 21865_CR80
  publication-title: Exp. Lung Res.
  doi: 10.3109/01902149809099588
– volume: 7
  start-page: e52886
  year: 2012
  ident: 21865_CR26
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0052886
– volume: 199
  start-page: 1517
  year: 2019
  ident: 21865_CR73
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201712-2410OC
– volume: 175
  start-page: 978
  year: 2007
  ident: 21865_CR56
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200611-1660PP
– volume: 587
  start-page: 619
  year: 2020
  ident: 21865_CR37
  publication-title: Nature
  doi: 10.1038/s41586-020-2922-4
– volume: 30
  start-page: 635
  year: 2004
  ident: 21865_CR58
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2003-0049OC
– volume: 52
  start-page: 617
  year: 2020
  ident: 21865_CR47
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2020.01.009
– volume: 10
  start-page: 1084
  year: 2019
  ident: 21865_CR71
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.01084
– volume: 1
  start-page: 417
  year: 2015
  ident: 21865_CR88
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2015.12.004
– volume: 265
  start-page: L627
  year: 1993
  ident: 21865_CR44
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.1993.265.6.L627
– volume: 182
  start-page: 1239
  year: 2010
  ident: 21865_CR59
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200909-1361OC
– volume: 200
  start-page: 1164
  year: 2019
  ident: 21865_CR62
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201812-2312OC
– volume: 115
  start-page: E1147
  year: 2018
  ident: 21865_CR31
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.1717802115
– volume: 44
  start-page: 377
  year: 2011
  ident: 21865_CR40
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2010-0158OC
– volume: 77
  start-page: 749
  year: 2015
  ident: 21865_CR49
  publication-title: Pediatr. Res.
  doi: 10.1038/pr.2015.46
– volume: 175
  start-page: 1031
  year: 2018
  ident: 21865_CR2
  publication-title: Cell
  doi: 10.1016/j.cell.2018.09.009
– volume: 245
  start-page: 153
  year: 2018
  ident: 21865_CR69
  publication-title: J. Pathol.
  doi: 10.1002/path.5076
– volume: 50
  start-page: 1317
  year: 2019
  ident: 21865_CR66
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.009
– volume: 20
  start-page: e272
  year: 2019
  ident: 21865_CR4
  publication-title: NeoRev.
  doi: 10.1542/neo.20-5-e272
– volume: 121
  start-page: 262
  year: 1992
  ident: 21865_CR13
  publication-title: J. Pediatr.
  doi: 10.1016/S0022-3476(05)81201-6
– volume: 44
  start-page: 621
  year: 2011
  ident: 21865_CR82
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2010-0058OC
– volume: 58
  start-page: 1204
  year: 2005
  ident: 21865_CR30
  publication-title: Pediatr. Res.
  doi: 10.1203/01.pdr.0000185269.93228.29
– volume: 16
  start-page: 619
  year: 2019
  ident: 21865_CR8
  publication-title: Nat. Methods
  doi: 10.1038/s41592-019-0433-8
– volume: 17
  start-page: e3000557
  year: 2019
  ident: 21865_CR60
  publication-title: PLOS Biol.
  doi: 10.1371/journal.pbio.3000557
– volume: 8
  start-page: 18670
  year: 2017
  ident: 21865_CR72
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.14722
– volume: 146
  start-page: dev176354
  year: 2019
  ident: 21865_CR33
  publication-title: Development
  doi: 10.1242/dev.176354
– volume: 20
  year: 2019
  ident: 21865_CR87
  publication-title: Genome Biol.
  doi: 10.1186/s13059-019-1874-1
– volume: 3
  start-page: e122490
  year: 2018
  ident: 21865_CR18
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.122490
– volume: 186
  start-page: 2519
  year: 2016
  ident: 21865_CR28
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2016.07.004
– volume: 129
  start-page: 2144
  year: 2014
  ident: 21865_CR61
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.114.009124
– volume: 17
  start-page: 159
  year: 2020
  ident: 21865_CR12
  publication-title: Nat. Methods
  doi: 10.1038/s41592-019-0667-5
– volume: 2
  start-page: 91
  year: 2015
  ident: 21865_CR41
  publication-title: Front. Med.
  doi: 10.3389/fmed.2015.00091
– volume: 196
  start-page: 3411
  year: 2016
  ident: 21865_CR81
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1500906
– volume: 313
  start-page: L733
  year: 2017
  ident: 21865_CR9
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00139.2017
– volume: 8
  start-page: 623
  year: 2017
  ident: 21865_CR53
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.00623
– volume: 4
  start-page: e126556
  year: 2019
  ident: 21865_CR65
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.126556
– volume: 9
  start-page: 138
  year: 2018
  ident: 21865_CR54
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2018.00138
– volume: 10
  year: 2019
  ident: 21865_CR1
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07770-1
– volume: 22
  start-page: 3625
  year: 2018
  ident: 21865_CR29
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.03.010
– volume: 24
  start-page: 179
  year: 2001
  ident: 21865_CR25
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/ajrcmb.24.2.3993
– volume: 6
  year: 2015
  ident: 21865_CR78
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms9977
– volume: 49
  start-page: 627
  year: 2013
  ident: 21865_CR24
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2012-0407OC
– volume: 8
  year: 2018
  ident: 21865_CR45
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-28190-7
– ident: 21865_CR74
  doi: 10.1126/sciadv.aaw3851
– volume: 170
  start-page: 1134
  year: 2017
  ident: 21865_CR21
  publication-title: Cell
  doi: 10.1016/j.cell.2017.07.034
– volume: 315
  start-page: L116
  year: 2018
  ident: 21865_CR23
  publication-title: Am. J. Physiol. -Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00527.2017
– volume: 367
  start-page: 481
  year: 2017
  ident: 21865_CR19
  publication-title: Cell Tissue Res.
  doi: 10.1007/s00441-016-2554-z
– volume: 586
  start-page: 785
  year: 2020
  ident: 21865_CR46
  publication-title: Nature
  doi: 10.1038/s41586-020-2822-7
– volume: 10
  year: 2019
  ident: 21865_CR35
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08831-9
– volume: 26
  start-page: 1079
  year: 2016
  ident: 21865_CR64
  publication-title: Cell Res.
  doi: 10.1038/cr.2016.85
– volume: 17
  year: 2019
  ident: 21865_CR76
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-019-1843-1
– volume: 19
  start-page: 539
  year: 2019
  ident: 21865_CR36
  publication-title: Expert Opin. Biol. Ther.
  doi: 10.1080/14712598.2019.1596256
– volume: 228
  start-page: 476
  year: 2013
  ident: 21865_CR38
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.24156
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Snippet During late lung development, alveolar and microvascular development is finalized to enable sufficient gas exchange. Impaired late lung development manifests...
It is unclear how changes in gene expression are induced by changes in oxygen levels during late lung development. Here, the authors provide data from...
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Alveoli
Animals
Biological activity
Bronchopulmonary Dysplasia - genetics
Bronchopulmonary Dysplasia - pathology
Crosstalk
Dysplasia
Endothelium
Epithelium
Fibroblasts
Gas exchange
Gene expression
Gene sequencing
Genotype
Humanities and Social Sciences
Hyperoxia
Hyperoxia - genetics
Hyperoxia - physiopathology
Infants
Inflammation
Lung - metabolism
Lung - pathology
Lungs
Macrophages
Male
Mice
Microvasculature
multidisciplinary
Oxygen
Phenotypes
Populations
Science
Science (multidisciplinary)
Sequence Analysis, RNA - methods
Single-Cell Analysis - methods
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