SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity

Dysregulation of YAP localization and activity is associated with pathological conditions such as cancer. Although activation of the Hippo phosphorylation cascade is known to cause cytoplasmic retention and inactivation of YAP, emerging evidence suggests that YAP can be regulated in a Hippo-independ...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 2269 - 16
Main Authors:	Yao, Fan, Zhou, Zhicheng, Kim, Jongchan, Hang, Qinglei, Xiao, Zhenna, Ton, Baochau N., Chang, Liang, Liu, Na, Zeng, Liyong, Wang, Wenqi, Wang, Yumeng, Zhang, Peijing, Hu, Xiaoyu, Su, Xiaohua, Liang, Han, Sun, Yutong, Ma, Li
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 11.06.2018 Nature Publishing Group Nature Portfolio
Subjects:	38/109 42/89 631/45/612/1254 631/80/2023/2022 631/80/458/582 64/60 82/29 82/83 96/95 Activation Active Transport, Cell Nucleus Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Amino Acid Substitution Animals Binding Sites - genetics Cancer Cell Line Cell Nucleus - metabolism Cytoplasm Deactivation DNA-Binding Proteins - metabolism Female Gene Knockout Techniques HEK293 Cells Humanities and Social Sciences Humans Inactivation Localization Mice multidisciplinary Mutagenesis, Site-Directed Nuclear Proteins - metabolism Phosphoproteins - chemistry Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proteolysis S-Phase Kinase-Associated Proteins - metabolism Science Science (multidisciplinary) Skp2 protein Transcription Transcription Factors - metabolism Ubiquitin-protein ligase Ubiquitin-Specific Proteases - metabolism Ubiquitination Yes-associated protein
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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