Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells

Non-alcoholic fatty liver disease (NAFLD) is a dominant cause of chronic liver disease, but the exact mechanism of progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains unknown. Here, we investigated the role of exosomes in NAFLD progression. Exosomes were isolated from a...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; pp. 3710 - 10
Main Authors:	Lee, Young-Sun, Kim, So Yeon, Ko, Eunjung, Lee, Jun-Hee, Yi, Hyon-Seung, Yoo, Yang Jae, Je, Jihye, Suh, Sang Jun, Jung, Young Kul, Kim, Ji Hoon, Seo, Yeon Seok, Yim, Hyung Joon, Jeong, Won-Il, Yeon, Jong Eun, Um, Soon Ho, Byun, Kwan Soo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.06.2017 Nature Publishing Group Nature Portfolio
Subjects:	13/95 45/61 631/80/86/820 692/4020/4021/1607/2750 692/4020/4021/1607/2751 Animals CD36 antigen Cell Line, Tumor Exosomes Exosomes - metabolism Exosomes - ultrastructure Fatty liver Fibrosis Gene Expression Profiling Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - ultrastructure Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - ultrastructure Hepatoma Humanities and Social Sciences Humans Liver cancer Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver diseases Male Mice MicroRNAs - genetics miRNA multidisciplinary Palmitic acid Palmitic Acid - pharmacology Science Science (multidisciplinary) Steatosis Stellate cells Transcriptome
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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