Ultra-large chemical libraries for the discovery of high-affinity peptide binders

High-diversity genetically-encoded combinatorial libraries (10 8 −10 13 members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 10 6 compounds by screening. Here we show that...

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Vydáno v:	Nature communications Ročník 11; číslo 1; s. 3183 - 11
Hlavní autoři:	Quartararo, Anthony J., Gates, Zachary P., Somsen, Bente A., Hartrampf, Nina, Ye, Xiyun, Shimada, Arisa, Kajihara, Yasuhiro, Ottmann, Christian, Pentelute, Bradley L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 23.06.2020 Nature Publishing Group Nature Portfolio
Témata:	14-3-3 protein 49/1 49/75 631/1647/296 639/638/45/611 639/638/92/2132/605 82/58 82/75 Affinity Amino Acid Sequence Amino Acids Antibodies, Monoclonal - chemistry Antibody Affinity Binders Binding Carrier Proteins - chemistry Chromatography, Liquid Combinatorial analysis Combinatorial libraries Crystallography, X-Ray Drug Design Drug Discovery Humanities and Social Sciences Libraries Liquid chromatography Mass spectrometry Mass spectroscopy MDM2 protein Models, Molecular Monoclonal antibodies multidisciplinary p53 Protein Peptide libraries Peptide Library Peptides Peptides - chemistry Proto-Oncogene Proteins c-mdm2 - chemistry Proto-Oncogene Proteins c-mdm2 - metabolism Randomization Science Science (multidisciplinary) Small Molecule Libraries - chemistry
ISSN:	2041-1723, 2041-1723
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Abstract	High-diversity genetically-encoded combinatorial libraries (10 8 −10 13 members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 10 6 compounds by screening. Here we show that in-solution affinity selection can be interfaced with nano-liquid chromatography-tandem mass spectrometry peptide sequencing to identify binders from fully randomized synthetic libraries of 10 8 members—a 100-fold gain in diversity over standard practice. To validate this approach, we show that binders to a monoclonal antibody are identified in proportion to library diversity, as diversity is increased from 10 6 –10 8 . These results are then applied to the discovery of p53-like binders to MDM2, and to a family of 3–19 nM-affinity, α/β-peptide-based binders to 14-3-3. An X-ray structure of one of these binders in complex with 14-3-3σ is determined, illustrating the role of β-amino acids in facilitating a key binding contact. Synthetic peptide libraries can access broad chemical space, but generally examine only ~ 10 6 compounds. Here, the authors show that in-solution affinity selection, interfaced with nLC-MS/MS sequencing, can identify binders from fully randomized synthetic libraries of 10 8 members.
AbstractList	Synthetic peptide libraries can access broad chemical space, but generally examine only ~ 106 compounds. Here, the authors show that in-solution affinity selection, interfaced with nLC-MS/MS sequencing, can identify binders from fully randomized synthetic libraries of 108 members. High-diversity genetically-encoded combinatorial libraries (10 8 −10 13 members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 10 6 compounds by screening. Here we show that in-solution affinity selection can be interfaced with nano-liquid chromatography-tandem mass spectrometry peptide sequencing to identify binders from fully randomized synthetic libraries of 10 8 members—a 100-fold gain in diversity over standard practice. To validate this approach, we show that binders to a monoclonal antibody are identified in proportion to library diversity, as diversity is increased from 10 6 –10 8 . These results are then applied to the discovery of p53-like binders to MDM2, and to a family of 3–19 nM-affinity, α/β-peptide-based binders to 14-3-3. An X-ray structure of one of these binders in complex with 14-3-3σ is determined, illustrating the role of β-amino acids in facilitating a key binding contact. High-diversity genetically-encoded combinatorial libraries (108−1013 members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 106 compounds by screening. Here we show that in-solution affinity selection can be interfaced with nano-liquid chromatography-tandem mass spectrometry peptide sequencing to identify binders from fully randomized synthetic libraries of 108 members—a 100-fold gain in diversity over standard practice. To validate this approach, we show that binders to a monoclonal antibody are identified in proportion to library diversity, as diversity is increased from 106–108. These results are then applied to the discovery of p53-like binders to MDM2, and to a family of 3–19 nM-affinity, α/β-peptide-based binders to 14-3-3. An X-ray structure of one of these binders in complex with 14-3-3σ is determined, illustrating the role of β-amino acids in facilitating a key binding contact.Synthetic peptide libraries can access broad chemical space, but generally examine only ~ 106 compounds. Here, the authors show that in-solution affinity selection, interfaced with nLC-MS/MS sequencing, can identify binders from fully randomized synthetic libraries of 108 members. High-diversity genetically-encoded combinatorial libraries (10 8 −10 13 members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 10 6 compounds by screening. Here we show that in-solution affinity selection can be interfaced with nano-liquid chromatography-tandem mass spectrometry peptide sequencing to identify binders from fully randomized synthetic libraries of 10 8 members—a 100-fold gain in diversity over standard practice. To validate this approach, we show that binders to a monoclonal antibody are identified in proportion to library diversity, as diversity is increased from 10 6 –10 8 . These results are then applied to the discovery of p53-like binders to MDM2, and to a family of 3–19 nM-affinity, α/β-peptide-based binders to 14-3-3. An X-ray structure of one of these binders in complex with 14-3-3σ is determined, illustrating the role of β-amino acids in facilitating a key binding contact. Synthetic peptide libraries can access broad chemical space, but generally examine only ~ 10 6 compounds. Here, the authors show that in-solution affinity selection, interfaced with nLC-MS/MS sequencing, can identify binders from fully randomized synthetic libraries of 10 8 members. High-diversity genetically-encoded combinatorial libraries (108−1013 members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 106 compounds by screening. Here we show that in-solution affinity selection can be interfaced with nano-liquid chromatography-tandem mass spectrometry peptide sequencing to identify binders from fully randomized synthetic libraries of 108 members—a 100-fold gain in diversity over standard practice. To validate this approach, we show that binders to a monoclonal antibody are identified in proportion to library diversity, as diversity is increased from 106–108. These results are then applied to the discovery of p53-like binders to MDM2, and to a family of 3–19 nM-affinity, α/β-peptide-based binders to 14-3-3. An X-ray structure of one of these binders in complex with 14-3-3σ is determined, illustrating the role of β-amino acids in facilitating a key binding contact. Synthetic peptide libraries can access broad chemical space, but generally examine only ~ 106 compounds. Here, the authors show that in-solution affinity selection, interfaced with nLC-MS/MS sequencing, can identify binders from fully randomized synthetic libraries of 108 members. High-diversity genetically-encoded combinatorial libraries (108-1013 members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 106 compounds by screening. Here we show that in-solution affinity selection can be interfaced with nano-liquid chromatography-tandem mass spectrometry peptide sequencing to identify binders from fully randomized synthetic libraries of 108 members-a 100-fold gain in diversity over standard practice. To validate this approach, we show that binders to a monoclonal antibody are identified in proportion to library diversity, as diversity is increased from 106-108. These results are then applied to the discovery of p53-like binders to MDM2, and to a family of 3-19 nM-affinity, α/β-peptide-based binders to 14-3-3. An X-ray structure of one of these binders in complex with 14-3-3σ is determined, illustrating the role of β-amino acids in facilitating a key binding contact.High-diversity genetically-encoded combinatorial libraries (108-1013 members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 106 compounds by screening. Here we show that in-solution affinity selection can be interfaced with nano-liquid chromatography-tandem mass spectrometry peptide sequencing to identify binders from fully randomized synthetic libraries of 108 members-a 100-fold gain in diversity over standard practice. To validate this approach, we show that binders to a monoclonal antibody are identified in proportion to library diversity, as diversity is increased from 106-108. These results are then applied to the discovery of p53-like binders to MDM2, and to a family of 3-19 nM-affinity, α/β-peptide-based binders to 14-3-3. An X-ray structure of one of these binders in complex with 14-3-3σ is determined, illustrating the role of β-amino acids in facilitating a key binding contact. High-diversity genetically-encoded combinatorial libraries (10 -10 members) are a rich source of peptide-based binding molecules, identified by affinity selection. Synthetic libraries can access broader chemical space, but typically examine only ~ 10 compounds by screening. Here we show that in-solution affinity selection can be interfaced with nano-liquid chromatography-tandem mass spectrometry peptide sequencing to identify binders from fully randomized synthetic libraries of 10 members-a 100-fold gain in diversity over standard practice. To validate this approach, we show that binders to a monoclonal antibody are identified in proportion to library diversity, as diversity is increased from 10 -10 . These results are then applied to the discovery of p53-like binders to MDM2, and to a family of 3-19 nM-affinity, α/β-peptide-based binders to 14-3-3. An X-ray structure of one of these binders in complex with 14-3-3σ is determined, illustrating the role of β-amino acids in facilitating a key binding contact.
ArticleNumber	3183
Author	Quartararo, Anthony J. Pentelute, Bradley L. Gates, Zachary P. Hartrampf, Nina Ye, Xiyun Ottmann, Christian Somsen, Bente A. Shimada, Arisa Kajihara, Yasuhiro
Author_xml	– sequence: 1 givenname: Anthony J. orcidid: 0000-0003-4995-1424 surname: Quartararo fullname: Quartararo, Anthony J. organization: Department of Chemistry, Massachusetts Institute of Technology – sequence: 2 givenname: Zachary P. surname: Gates fullname: Gates, Zachary P. organization: Department of Chemistry, Massachusetts Institute of Technology – sequence: 3 givenname: Bente A. orcidid: 0000-0003-4862-3787 surname: Somsen fullname: Somsen, Bente A. organization: Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology – sequence: 4 givenname: Nina orcidid: 0000-0003-0875-6390 surname: Hartrampf fullname: Hartrampf, Nina organization: Department of Chemistry, Massachusetts Institute of Technology – sequence: 5 givenname: Xiyun surname: Ye fullname: Ye, Xiyun organization: Department of Chemistry, Massachusetts Institute of Technology – sequence: 6 givenname: Arisa surname: Shimada fullname: Shimada, Arisa organization: Department of Chemistry, Graduate School of Science, Osaka University – sequence: 7 givenname: Yasuhiro surname: Kajihara fullname: Kajihara, Yasuhiro organization: Department of Chemistry, Graduate School of Science, Osaka University – sequence: 8 givenname: Christian surname: Ottmann fullname: Ottmann, Christian organization: Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology – sequence: 9 givenname: Bradley L. orcidid: 0000-0002-7242-801X surname: Pentelute fullname: Pentelute, Bradley L. email: blp@mit.edu organization: Department of Chemistry, Massachusetts Institute of Technology, The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Center for Environmental Health Sciences, Massachusetts Institute of Technology, Broad Institute of MIT and Harvard
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32576815$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1006/jmbi.1994.1530 10.1038/nchembio.184 10.1016/S0092-8674(00)80487-0 10.1021/ja055050o 10.1016/0079-6107(93)90015-C 10.1021/jm040031v 10.1016/j.cbpa.2009.04.627 10.1016/0167-7799(94)90079-5 10.1073/pnas.89.10.4505 10.1039/C6MD00221H 10.1021/jacs.8b07247 10.1021/cr3003533 10.1038/nbt785 10.1021/acscombsci.7b00109 10.1002/prca.200700009 10.1002/anie.201701807 10.1073/pnas.061028198 10.1038/354082a0 10.1080/17460441.2019.1614559 10.1038/s41589-019-0245-2 10.1016/S1359-6446(98)01220-3 10.1111/j.1399-3011.1991.tb00765.x 10.1016/j.jmb.2010.03.005 10.1073/pnas.1809901115 10.1002/rcm.1196 10.1002/(SICI)1097-0231(199707)11:11<1178::AID-RCM991>3.0.CO;2-H 10.1021/ac970132j 10.1007/s13361-016-1564-0 10.1021/jacs.8b13178 10.1021/acs.jmedchem.7b00574 10.1021/jacs.5b11742 10.1002/anie.201207005 10.1021/cr9600114 10.1002/cbic.201800766 10.1021/ja0563455 10.1016/j.chembiol.2016.11.012 10.1073/pnas.1208396109 10.1039/c0cc03272g 10.1073/pnas.1413185112 10.2174/138620708783398340 10.1002/cbic.201300796 10.1021/jm4011675 10.1016/j.trac.2017.02.011 10.1073/pnas.1303002110 10.1016/j.drudis.2015.09.007 10.1021/cb700233t 10.1023/A:1026369729393 10.1038/nchembio.2153 10.1517/17460441.2015.1076790 10.1073/pnas.0900947106 10.1158/0008-5472.CAN-07-1140 10.1021/ja036417x 10.1073/pnas.1722633115 10.1016/j.cbpa.2017.02.020 10.1016/S0958-1669(98)80092-X 10.1038/nchembio.2318 10.1021/acs.orglett.6b00296 10.1016/j.ejmech.2015.01.014 10.1038/nbt0197-29
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References	Ma (CR37) 2003; 17 Pazgier (CR45) 2009; 106 Dunayevskiy, Lai, Quinn, Talley, Vouros (CR26) 1997; 11 Furka, Sebestyén, Asgedom, Dibó (CR36) 1991; 37 Clackson, Wells (CR14) 1994; 12 Lam, Lebl, Krchňák (CR23) 1997; 97 Alluri, Reddy, Bachhawat-Sikder, Olivos, Kodadek (CR42) 2003; 125 Rogers, Passioura, Suga (CR13) 2018; 115 Katoh, Suga (CR19) 2018; 140 Churchill (CR38) 1994; 241 Gates (CR24) 2018; 115 Leshchiner (CR8) 2015; 112 Katoh, Tajima, Suga (CR18) 2017; 24 Rush, Walker, Prehna, Burton, van Breemen (CR34) 2017; 28 de Vink (CR50) 2017; 56 Yaffe (CR49) 1997; 91 Simon (CR60) 2014; 15 Vinogradov (CR30) 2017; 19 Efimov (CR51) 1993; 60 Feldhaus (CR41) 2003; 21 Maaty, Weis (CR29) 2016; 138 Kritzer, Luedtke, Harker, Schepartz (CR47) 2005; 127 Heinis, Rutherford, Freund, Winter (CR56) 2009; 5 Wilson, Keefe, Szostak (CR16) 2001; 98 Mijalis (CR61) 2017; 13 Eidam, L. Satz (CR20) 2016; 7 Griffiths, Duncan (CR52) 1998; 9 Georgiou (CR40) 1997; 15 Goto (CR57) 2008; 3 van Breemen (CR28) 1997; 69 Nizami (CR55) 2020; 48 Liang, Vézina-Dawod, Bédard, Porte, Biron (CR59) 2016; 18 Erlanson, McDowell, O’Brien (CR2) 2004; 47 Sannino (CR35) 2019; 20 Grossmann (CR6) 2012; 109 Tsomaia (CR4) 2015; 94 Lee, Meyer, Lim (CR58) 2010; 46 Zhang, Fonslow, Shan, Baek, Yates (CR53) 2013; 113 Gebauer, Skerra (CR3) 2009; 13 Li (CR46) 2010; 398 Walensky, Bird (CR10) 2014; 57 Rezai, Yu, Millhauser, Jacobson, Lokey (CR9) 2006; 128 Obexer, Walport, Suga (CR17) 2017; 38 Kaur, McGuire, Tang, Dollinger, Huebner (CR27) 1997; 16 Lam (CR22) 1991; 354 Hu, Gilkes, Chen (CR44) 2007; 67 Olson (CR39) 2012; 51 Mignani, Huber, Tomás, Rodrigues, Majoral (CR1) 2016; 21 Vinogradov, Yin, Suga (CR5) 2019; 141 Zuckermann, Kerr, Siani, Banville, Santi (CR25) 1992; 89 Choi, van Breemen (CR33) 2008; 11 Stevers (CR48) 2018; 61 Mándity, Fülöp (CR54) 2015; 10 Li, Popp, Borchers (CR32) 2017; 90 Bird (CR11) 2016; 12 Chang (CR7) 2013; 110 Touti, Gates, Bandyopadhyay, Lautrette, Pentelute (CR12) 2019; 15 Kay, Kurakin, Hyde-DeRuyscher (CR15) 1998; 3 Böttger (CR43) 1996; 13 Jiang (CR31) 2007; 1 Zhao, Huang, Zhou, Li, Li (CR21) 2019; 14 V Böttger (16920_CR43) 1996; 13 ME Churchill (16920_CR38) 1994; 241 M Gebauer (16920_CR3) 2009; 13 B Ma (16920_CR37) 2003; 17 ZP Gates (16920_CR24) 2018; 115 S Mignani (16920_CR1) 2016; 21 BK Kay (16920_CR15) 1998; 3 A Furka (16920_CR36) 1991; 37 DS Wilson (16920_CR16) 2001; 98 YM Dunayevskiy (16920_CR26) 1997; 11 Y Choi (16920_CR33) 2008; 11 AD Griffiths (16920_CR52) 1998; 9 RN Zuckermann (16920_CR25) 1992; 89 S Kaur (16920_CR27) 1997; 16 B Hu (16920_CR44) 2007; 67 KS Lam (16920_CR23) 1997; 97 MD Simon (16920_CR60) 2014; 15 T Katoh (16920_CR19) 2018; 140 WS Maaty (16920_CR29) 2016; 138 Y Zhang (16920_CR53) 2013; 113 MD Rush (16920_CR34) 2017; 28 AV Efimov (16920_CR51) 1993; 60 MJ Feldhaus (16920_CR41) 2003; 21 PG Alluri (16920_CR42) 2003; 125 GH Bird (16920_CR11) 2016; 12 C Li (16920_CR46) 2010; 398 YS Chang (16920_CR7) 2013; 110 AJ Mijalis (16920_CR61) 2017; 13 T Katoh (16920_CR18) 2017; 24 JA Kritzer (16920_CR47) 2005; 127 T Rezai (16920_CR9) 2006; 128 O Eidam (16920_CR20) 2016; 7 LD Walensky (16920_CR10) 2014; 57 JH Lee (16920_CR58) 2010; 46 X Liang (16920_CR59) 2016; 18 C Heinis (16920_CR56) 2009; 5 JM Rogers (16920_CR13) 2018; 115 AA Vinogradov (16920_CR5) 2019; 141 N Tsomaia (16920_CR4) 2015; 94 Y Goto (16920_CR57) 2008; 3 PJ de Vink (16920_CR50) 2017; 56 ES Leshchiner (16920_CR8) 2015; 112 KS Lam (16920_CR22) 1991; 354 MB Yaffe (16920_CR49) 1997; 91 F Touti (16920_CR12) 2019; 15 B Nizami (16920_CR55) 2020; 48 A Sannino (16920_CR35) 2019; 20 M Pazgier (16920_CR45) 2009; 106 TN Grossmann (16920_CR6) 2012; 109 CA Olson (16920_CR39) 2012; 51 LM Stevers (16920_CR48) 2018; 61 R Obexer (16920_CR17) 2017; 38 DA Erlanson (16920_CR2) 2004; 47 AA Vinogradov (16920_CR30) 2017; 19 J Jiang (16920_CR31) 2007; 1 IM Mándity (16920_CR54) 2015; 10 RB van Breemen (16920_CR28) 1997; 69 G Georgiou (16920_CR40) 1997; 15 H Li (16920_CR32) 2017; 90 T Clackson (16920_CR14) 1994; 12 G Zhao (16920_CR21) 2019; 14
References_xml	– volume: 241 start-page: 534 year: 1994 end-page: 556 ident: CR38 article-title: Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9. Comparison of two different antibodies bound to the same peptide antigen publication-title: J. Mol. Biol. doi: 10.1006/jmbi.1994.1530 – volume: 5 start-page: 502 year: 2009 end-page: 507 ident: CR56 article-title: Phage-encoded combinatorial chemical libraries based on bicyclic peptides publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.184 – volume: 91 start-page: 961 year: 1997 end-page: 971 ident: CR49 article-title: The structural basis for 14-3-3:phosphopeptide binding specificity publication-title: Cell doi: 10.1016/S0092-8674(00)80487-0 – volume: 127 start-page: 14584 year: 2005 end-page: 14585 ident: CR47 article-title: A rapid library screen for tailoring β-peptide structure and function publication-title: J. Am. Chem. Soc. doi: 10.1021/ja055050o – volume: 60 start-page: 201 year: 1993 end-page: 239 ident: CR51 article-title: Standard structures in proteins publication-title: Prog. Biophysics Mol. Biol. doi: 10.1016/0079-6107(93)90015-C – volume: 47 start-page: 3463 year: 2004 end-page: 3482 ident: CR2 article-title: Fragment-based drug discovery publication-title: J. Med. Chem. doi: 10.1021/jm040031v – volume: 13 start-page: 245 year: 2009 end-page: 255 ident: CR3 article-title: Engineered protein scaffolds as next-generation antibody therapeutics publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2009.04.627 – volume: 12 start-page: 173 year: 1994 end-page: 184 ident: CR14 article-title: In vitro selection from protein and peptide libraries publication-title: Trends Biotechnol. doi: 10.1016/0167-7799(94)90079-5 – volume: 89 start-page: 4505 year: 1992 end-page: 4509 ident: CR25 article-title: Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.89.10.4505 – volume: 7 start-page: 1323 year: 2016 end-page: 1331 ident: CR20 article-title: Analysis of the productivity of DNA encoded libraries publication-title: MedChemComm doi: 10.1039/C6MD00221H – volume: 140 start-page: 12159 year: 2018 end-page: 12167 ident: CR19 article-title: Ribosomal incorporation of consecutive β-amino acids publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b07247 – volume: 113 start-page: 2343 year: 2013 end-page: 2394 ident: CR53 article-title: Protein analysis by shotgun/bottom-up proteomics publication-title: Chem. Rev. doi: 10.1021/cr3003533 – volume: 21 start-page: 163 year: 2003 end-page: 170 ident: CR41 article-title: Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library publication-title: Nat. Biotechnol. doi: 10.1038/nbt785 – volume: 19 start-page: 694 year: 2017 end-page: 701 ident: CR30 article-title: Library design-facilitated high-throughput sequencing of synthetic peptide libraries publication-title: ACS Comb. Sci. doi: 10.1021/acscombsci.7b00109 – volume: 1 start-page: 1651 year: 2007 end-page: 1659 ident: CR31 article-title: Development of an immuno tandem mass spectrometry (iMALDI) assay for EGFR diagnosis publication-title: Proteom. Clin. Appl. doi: 10.1002/prca.200700009 – volume: 56 start-page: 8998 year: 2017 end-page: 9002 ident: CR50 article-title: A binary bivalent supramolecular assembly platform based on Cucurbit[8]uril and dimeric adapter protein 14-3-3 publication-title: Angew. Chem. Int Ed. Engl. doi: 10.1002/anie.201701807 – volume: 98 start-page: 3750 year: 2001 end-page: 3755 ident: CR16 article-title: The use of mRNA display to select high-affinity protein-binding peptides publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.061028198 – volume: 354 start-page: 82 year: 1991 end-page: 84 ident: CR22 article-title: A new type of synthetic peptide library for identifying ligand-binding activity publication-title: Nature doi: 10.1038/354082a0 – volume: 14 start-page: 735 year: 2019 end-page: 753 ident: CR21 article-title: Future challenges with DNA-encoded chemical libraries in the drug discovery domain publication-title: Expert Opin. Drug Discov. doi: 10.1080/17460441.2019.1614559 – volume: 15 start-page: 410 year: 2019 end-page: 418 ident: CR12 article-title: In-solution enrichment identifies peptide inhibitors of protein–protein interactions publication-title: Nat. Chem. Biol. doi: 10.1038/s41589-019-0245-2 – volume: 13 start-page: 2141 year: 1996 end-page: 2147 ident: CR43 article-title: Identification of novel mdm2 binding peptides by phage display publication-title: Oncogene – volume: 3 start-page: 370 year: 1998 end-page: 378 ident: CR15 article-title: From peptides to drugs via phage display publication-title: Drug Discov. Today doi: 10.1016/S1359-6446(98)01220-3 – volume: 37 start-page: 487 year: 1991 end-page: 493 ident: CR36 article-title: General method for rapid synthesis of multicomponent peptide mixtures publication-title: Int. J. Pept. Protein Res. doi: 10.1111/j.1399-3011.1991.tb00765.x – volume: 398 start-page: 200 year: 2010 end-page: 213 ident: CR46 article-title: Systematic mutational analysis of peptide inhibition of the p53–MDM2/MDMX interactions publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2010.03.005 – volume: 115 start-page: 10959 year: 2018 end-page: 10964 ident: CR13 article-title: Nonproteinogenic deep mutational scanning of linear and cyclic peptides publication-title: Proc. Natl Acad. Sci USA. doi: 10.1073/pnas.1809901115 – volume: 17 start-page: 2337 year: 2003 end-page: 2342 ident: CR37 article-title: PEAKS: powerful software for peptidede novo sequencing by tandem mass spectrometry publication-title: Rapid Commun. Mass Spectrom. doi: 10.1002/rcm.1196 – volume: 11 start-page: 1178 year: 1997 end-page: 1184 ident: CR26 article-title: Mass spectrometric identification of ligands selected from combinatorial libraries using gel filtration publication-title: Rapid Commun. Mass Spectrom. doi: 10.1002/(SICI)1097-0231(199707)11:11<1178::AID-RCM991>3.0.CO;2-H – volume: 69 start-page: 2159 year: 1997 end-page: 2164 ident: CR28 article-title: Pulsed ultrafiltration mass spectrometry: a new method for screening combinatorial libraries publication-title: Anal. Chem. doi: 10.1021/ac970132j – volume: 28 start-page: 479 year: 2017 end-page: 485 ident: CR34 article-title: Development of a magnetic microbead affinity selection screen (MagMASS) using mass spectrometry for ligands to the retinoid X receptor-α publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-016-1564-0 – volume: 141 start-page: 4167 year: 2019 end-page: 4181 ident: CR5 article-title: Macrocyclic peptides as drug candidates: recent progress and remaining challenges publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b13178 – volume: 61 start-page: 3755 year: 2018 end-page: 3778 ident: CR48 article-title: Modulators of 14-3-3 protein–protein interactions publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.7b00574 – volume: 138 start-page: 1335 year: 2016 end-page: 1343 ident: CR29 article-title: Label-free, in-solution screening of peptide libraries for binding to protein targets using hydrogen exchange mass spectrometry publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.5b11742 – volume: 51 start-page: 12449 year: 2012 end-page: 12453 ident: CR39 article-title: Single-round, multiplexed antibody mimetic design through mRNA display publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.201207005 – volume: 48 start-page: D1122 year: 2020 end-page: D1128 ident: CR55 article-title: FoldamerDB: a database of peptidic foldamers publication-title: Nucleic Acids Res – volume: 97 start-page: 411 year: 1997 end-page: 448 ident: CR23 article-title: The “One-Bead-One-Compound” Combinatorial Library Method publication-title: Chem. Rev. doi: 10.1021/cr9600114 – volume: 20 start-page: 955 year: 2019 end-page: 962 ident: CR35 article-title: Quantitative assessment of affinity selection performance by using DNA-encoded chemical libraries publication-title: ChemBioChem doi: 10.1002/cbic.201800766 – volume: 128 start-page: 2510 year: 2006 end-page: 2511 ident: CR9 article-title: Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers publication-title: J. Am. Chem. Soc. doi: 10.1021/ja0563455 – volume: 24 start-page: 46 year: 2017 end-page: 54 ident: CR18 article-title: Consecutive elongation of D-Amino acids in translation publication-title: Cell Chem. Biol. doi: 10.1016/j.chembiol.2016.11.012 – volume: 109 start-page: 17942 year: 2012 end-page: 17947 ident: CR6 article-title: Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin publication-title: Proc Natl Acad. Sci. USA doi: 10.1073/pnas.1208396109 – volume: 46 start-page: 8615 year: 2010 end-page: 8617 ident: CR58 article-title: A simple strategy for the construction of combinatorial cyclic peptoid libraries publication-title: Chem. Commun. doi: 10.1039/c0cc03272g – volume: 112 start-page: 1761 year: 2015 end-page: 1766 ident: CR8 article-title: Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1413185112 – volume: 11 start-page: 1 year: 2008 end-page: 6 ident: CR33 article-title: Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS publication-title: Comb. Chem. High. Throughput Screen. doi: 10.2174/138620708783398340 – volume: 15 start-page: 713 year: 2014 end-page: 720 ident: CR60 article-title: Rapid flow-based peptide synthesis publication-title: ChemBioChem doi: 10.1002/cbic.201300796 – volume: 57 start-page: 6275 year: 2014 end-page: 6288 ident: CR10 article-title: Hydrocarbon-stapled peptides: principles, practice, and progress publication-title: J. Med. Chem. doi: 10.1021/jm4011675 – volume: 90 start-page: 80 year: 2017 end-page: 88 ident: CR32 article-title: Affinity-mass spectrometric technologies for quantitative proteomics in biological fluids publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2017.02.011 – volume: 110 start-page: E3445 year: 2013 end-page: E3454 ident: CR7 article-title: Stapled α−helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy publication-title: PRoc. Natl Acd. Sci USA doi: 10.1073/pnas.1303002110 – volume: 21 start-page: 239 year: 2016 end-page: 249 ident: CR1 article-title: Why and how have drug discovery strategies in pharma changed? What are the new mindsets? publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2015.09.007 – volume: 3 start-page: 120 year: 2008 end-page: 129 ident: CR57 article-title: Reprogramming the translation initiation for the synthesis of physiologically stable cyclic peptides publication-title: ACS Chem. Biol. doi: 10.1021/cb700233t – volume: 16 start-page: 505 year: 1997 end-page: 511 ident: CR27 article-title: Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries publication-title: J. Protein Chem. doi: 10.1023/A:1026369729393 – volume: 12 start-page: 845 year: 2016 end-page: 852 ident: CR11 article-title: Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.2153 – volume: 10 start-page: 1163 year: 2015 end-page: 1177 ident: CR54 article-title: An overview of peptide and peptoid foldamers in medicinal chemistry publication-title: Expert Opin. Drug Discov. doi: 10.1517/17460441.2015.1076790 – volume: 106 start-page: 4665 year: 2009 end-page: 4670 ident: CR45 article-title: Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0900947106 – volume: 67 start-page: 8810 year: 2007 end-page: 8817 ident: CR44 article-title: Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-1140 – volume: 125 start-page: 13995 year: 2003 end-page: 14004 ident: CR42 article-title: Isolation of protein ligands from large peptoid libraries publication-title: J. Am. Chem. Soc. doi: 10.1021/ja036417x – volume: 115 start-page: E5298 year: 2018 end-page: E5306 ident: CR24 article-title: Xenoprotein engineering via synthetic libraries publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1722633115 – volume: 38 start-page: 52 year: 2017 end-page: 61 ident: CR17 article-title: Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2017.02.020 – volume: 9 start-page: 102 year: 1998 end-page: 108 ident: CR52 article-title: Strategies for selection of antibodies by phage display publication-title: Curr. Opin. Biotechnol. doi: 10.1016/S0958-1669(98)80092-X – volume: 13 start-page: 464 year: 2017 end-page: 466 ident: CR61 article-title: A fully automated flow-based approach for accelerated peptide synthesis publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.2318 – volume: 18 start-page: 1174 year: 2016 end-page: 1177 ident: CR59 article-title: One-pot photochemical ring-opening/cleavage approach for the synthesis and decoding of cyclic peptide libraries publication-title: Org. Lett. doi: 10.1021/acs.orglett.6b00296 – volume: 94 start-page: 459 year: 2015 end-page: 470 ident: CR4 article-title: Peptide therapeutics: targeting the undruggable space publication-title: Eur. J. Medicinal Chem. doi: 10.1016/j.ejmech.2015.01.014 – volume: 15 start-page: 29 year: 1997 end-page: 34 ident: CR40 article-title: Display of heterologous proteins on the surface of microorganisms: From the screening of combinatorial libraries to live recombinant vaccines publication-title: Nat. Biotechnol. doi: 10.1038/nbt0197-29 – volume: 106 start-page: 4665 year: 2009 ident: 16920_CR45 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0900947106 – volume: 12 start-page: 173 year: 1994 ident: 16920_CR14 publication-title: Trends Biotechnol. doi: 10.1016/0167-7799(94)90079-5 – volume: 7 start-page: 1323 year: 2016 ident: 16920_CR20 publication-title: MedChemComm doi: 10.1039/C6MD00221H – volume: 15 start-page: 29 year: 1997 ident: 16920_CR40 publication-title: Nat. Biotechnol. doi: 10.1038/nbt0197-29 – volume: 61 start-page: 3755 year: 2018 ident: 16920_CR48 publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.7b00574 – volume: 19 start-page: 694 year: 2017 ident: 16920_CR30 publication-title: ACS Comb. Sci. doi: 10.1021/acscombsci.7b00109 – volume: 48 start-page: D1122 year: 2020 ident: 16920_CR55 publication-title: Nucleic Acids Res – volume: 13 start-page: 464 year: 2017 ident: 16920_CR61 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.2318 – volume: 398 start-page: 200 year: 2010 ident: 16920_CR46 publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2010.03.005 – volume: 14 start-page: 735 year: 2019 ident: 16920_CR21 publication-title: Expert Opin. Drug Discov. doi: 10.1080/17460441.2019.1614559 – volume: 90 start-page: 80 year: 2017 ident: 16920_CR32 publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2017.02.011 – volume: 354 start-page: 82 year: 1991 ident: 16920_CR22 publication-title: Nature doi: 10.1038/354082a0 – volume: 110 start-page: E3445 year: 2013 ident: 16920_CR7 publication-title: PRoc. Natl Acd. Sci USA doi: 10.1073/pnas.1303002110 – volume: 12 start-page: 845 year: 2016 ident: 16920_CR11 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.2153 – volume: 9 start-page: 102 year: 1998 ident: 16920_CR52 publication-title: Curr. Opin. Biotechnol. doi: 10.1016/S0958-1669(98)80092-X – volume: 60 start-page: 201 year: 1993 ident: 16920_CR51 publication-title: Prog. Biophysics Mol. Biol. doi: 10.1016/0079-6107(93)90015-C – volume: 3 start-page: 370 year: 1998 ident: 16920_CR15 publication-title: Drug Discov. Today doi: 10.1016/S1359-6446(98)01220-3 – volume: 140 start-page: 12159 year: 2018 ident: 16920_CR19 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b07247 – volume: 47 start-page: 3463 year: 2004 ident: 16920_CR2 publication-title: J. Med. Chem. doi: 10.1021/jm040031v – volume: 20 start-page: 955 year: 2019 ident: 16920_CR35 publication-title: ChemBioChem doi: 10.1002/cbic.201800766 – volume: 56 start-page: 8998 year: 2017 ident: 16920_CR50 publication-title: Angew. Chem. Int Ed. Engl. doi: 10.1002/anie.201701807 – volume: 115 start-page: 10959 year: 2018 ident: 16920_CR13 publication-title: Proc. Natl Acad. Sci USA. doi: 10.1073/pnas.1809901115 – volume: 10 start-page: 1163 year: 2015 ident: 16920_CR54 publication-title: Expert Opin. Drug Discov. doi: 10.1517/17460441.2015.1076790 – volume: 97 start-page: 411 year: 1997 ident: 16920_CR23 publication-title: Chem. Rev. doi: 10.1021/cr9600114 – volume: 115 start-page: E5298 year: 2018 ident: 16920_CR24 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1722633115 – volume: 16 start-page: 505 year: 1997 ident: 16920_CR27 publication-title: J. Protein Chem. doi: 10.1023/A:1026369729393 – volume: 13 start-page: 2141 year: 1996 ident: 16920_CR43 publication-title: Oncogene – volume: 15 start-page: 410 year: 2019 ident: 16920_CR12 publication-title: Nat. Chem. Biol. doi: 10.1038/s41589-019-0245-2 – volume: 109 start-page: 17942 year: 2012 ident: 16920_CR6 publication-title: Proc Natl Acad. Sci. USA doi: 10.1073/pnas.1208396109 – volume: 91 start-page: 961 year: 1997 ident: 16920_CR49 publication-title: Cell doi: 10.1016/S0092-8674(00)80487-0 – volume: 141 start-page: 4167 year: 2019 ident: 16920_CR5 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.8b13178 – volume: 13 start-page: 245 year: 2009 ident: 16920_CR3 publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2009.04.627 – volume: 138 start-page: 1335 year: 2016 ident: 16920_CR29 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.5b11742 – volume: 67 start-page: 8810 year: 2007 ident: 16920_CR44 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-1140 – volume: 11 start-page: 1178 year: 1997 ident: 16920_CR26 publication-title: Rapid Commun. Mass Spectrom. doi: 10.1002/(SICI)1097-0231(199707)11:11<1178::AID-RCM991>3.0.CO;2-H – volume: 98 start-page: 3750 year: 2001 ident: 16920_CR16 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.061028198 – volume: 46 start-page: 8615 year: 2010 ident: 16920_CR58 publication-title: Chem. Commun. doi: 10.1039/c0cc03272g – volume: 28 start-page: 479 year: 2017 ident: 16920_CR34 publication-title: J. Am. Soc. Mass Spectrom. doi: 10.1007/s13361-016-1564-0 – volume: 113 start-page: 2343 year: 2013 ident: 16920_CR53 publication-title: Chem. Rev. doi: 10.1021/cr3003533 – volume: 3 start-page: 120 year: 2008 ident: 16920_CR57 publication-title: ACS Chem. Biol. doi: 10.1021/cb700233t – volume: 94 start-page: 459 year: 2015 ident: 16920_CR4 publication-title: Eur. J. Medicinal Chem. doi: 10.1016/j.ejmech.2015.01.014 – volume: 1 start-page: 1651 year: 2007 ident: 16920_CR31 publication-title: Proteom. Clin. Appl. doi: 10.1002/prca.200700009 – volume: 38 start-page: 52 year: 2017 ident: 16920_CR17 publication-title: Curr. Opin. Chem. Biol. doi: 10.1016/j.cbpa.2017.02.020 – volume: 125 start-page: 13995 year: 2003 ident: 16920_CR42 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja036417x – volume: 11 start-page: 1 year: 2008 ident: 16920_CR33 publication-title: Comb. Chem. High. Throughput Screen. doi: 10.2174/138620708783398340 – volume: 241 start-page: 534 year: 1994 ident: 16920_CR38 publication-title: J. Mol. Biol. doi: 10.1006/jmbi.1994.1530 – volume: 51 start-page: 12449 year: 2012 ident: 16920_CR39 publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.201207005 – volume: 5 start-page: 502 year: 2009 ident: 16920_CR56 publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.184 – volume: 21 start-page: 239 year: 2016 ident: 16920_CR1 publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2015.09.007 – volume: 18 start-page: 1174 year: 2016 ident: 16920_CR59 publication-title: Org. Lett. doi: 10.1021/acs.orglett.6b00296 – volume: 37 start-page: 487 year: 1991 ident: 16920_CR36 publication-title: Int. J. Pept. Protein Res. doi: 10.1111/j.1399-3011.1991.tb00765.x – volume: 57 start-page: 6275 year: 2014 ident: 16920_CR10 publication-title: J. Med. Chem. doi: 10.1021/jm4011675 – volume: 24 start-page: 46 year: 2017 ident: 16920_CR18 publication-title: Cell Chem. Biol. doi: 10.1016/j.chembiol.2016.11.012 – volume: 17 start-page: 2337 year: 2003 ident: 16920_CR37 publication-title: Rapid Commun. Mass Spectrom. doi: 10.1002/rcm.1196 – volume: 15 start-page: 713 year: 2014 ident: 16920_CR60 publication-title: ChemBioChem doi: 10.1002/cbic.201300796 – volume: 21 start-page: 163 year: 2003 ident: 16920_CR41 publication-title: Nat. Biotechnol. doi: 10.1038/nbt785 – volume: 89 start-page: 4505 year: 1992 ident: 16920_CR25 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.89.10.4505 – volume: 127 start-page: 14584 year: 2005 ident: 16920_CR47 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja055050o – volume: 112 start-page: 1761 year: 2015 ident: 16920_CR8 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1413185112 – volume: 128 start-page: 2510 year: 2006 ident: 16920_CR9 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja0563455 – volume: 69 start-page: 2159 year: 1997 ident: 16920_CR28 publication-title: Anal. Chem. doi: 10.1021/ac970132j
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Snippet	High-diversity genetically-encoded combinatorial libraries (10 8 −10 13 members) are a rich source of peptide-based binding molecules, identified by affinity... High-diversity genetically-encoded combinatorial libraries (10 -10 members) are a rich source of peptide-based binding molecules, identified by affinity... High-diversity genetically-encoded combinatorial libraries (108−1013 members) are a rich source of peptide-based binding molecules, identified by affinity... High-diversity genetically-encoded combinatorial libraries (108-1013 members) are a rich source of peptide-based binding molecules, identified by affinity... Synthetic peptide libraries can access broad chemical space, but generally examine only ~ 106 compounds. Here, the authors show that in-solution affinity...
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SubjectTerms	14-3-3 protein 49/1 49/75 631/1647/296 639/638/45/611 639/638/92/2132/605 82/58 82/75 Affinity Amino Acid Sequence Amino Acids Antibodies, Monoclonal - chemistry Antibody Affinity Binders Binding Carrier Proteins - chemistry Chromatography, Liquid Combinatorial analysis Combinatorial libraries Crystallography, X-Ray Drug Design Drug Discovery Humanities and Social Sciences Libraries Liquid chromatography Mass spectrometry Mass spectroscopy MDM2 protein Models, Molecular Monoclonal antibodies multidisciplinary p53 Protein Peptide libraries Peptide Library Peptides Peptides - chemistry Proto-Oncogene Proteins c-mdm2 - chemistry Proto-Oncogene Proteins c-mdm2 - metabolism Randomization Science Science (multidisciplinary) Small Molecule Libraries - chemistry
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Title	Ultra-large chemical libraries for the discovery of high-affinity peptide binders
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