Targeted removal of epigenetic barriers during transcriptional reprogramming

Master transcription factors have the ability to direct and reverse cellular identities, and consequently their genes must be subject to particular transcriptional control. However, it is unclear which molecular processes are responsible for impeding their activation and safeguarding cellular identi...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 2119 - 12
Main Authors:	Baumann, Valentin, Wiesbeck, Maximilian, Breunig, Christopher T., Braun, Julia M., Köferle, Anna, Ninkovic, Jovica, Götz, Magdalena, Stricker, Stefan H.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.05.2019 Nature Publishing Group Nature Portfolio
Subjects:	13/100 13/109 38 38/22 38/77 38/88 38/91 631/136/2435 631/1647/2017 631/1647/2210 631/208/176/1988 631/208/4041 64 64/60 Activation Animals Cell Differentiation - genetics Cell Line Cells (biology) Cellular Reprogramming - genetics CRISPR-Cas Systems - genetics Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenesis, Genetic Gene Editing - methods Gene expression Gene Expression Regulation Humanities and Social Sciences Mice multidisciplinary Neural stem cells Neural Stem Cells - physiology Neuroglia - cytology Neuroglia - physiology Progenitor cells Promoter Regions, Genetic - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA, Guide, CRISPR-Cas Systems Science Science (multidisciplinary) SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Transcription factors Transcription, Genetic - genetics
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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