CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain

Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dynamics in the brain, the development of a device with both wide-area detectability and high spatial-ltemporal resolution is necessary....

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 712 - 9
Main Authors:	Horiuchi, Hiroshi, Agetsuma, Masakazu, Ishida, Junko, Nakamura, Yusuke, Lawrence Cheung, Dennis, Nanasaki, Shin, Kimura, Yasuyuki, Iwata, Tatsuya, Takahashi, Kazuhiro, Sawada, Kazuaki, Nabekura, Junichi
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.02.2020 Nature Publishing Group Nature Portfolio
Subjects:	631/1647/1888 631/1647/245 9/10 Animal models Animals Biosensing Techniques - instrumentation Biosensing Techniques - methods Biosensors Brain Brain - diagnostic imaging Brain - physiology Brain Chemistry Change detection CMOS Equipment Design Humanities and Social Sciences Hydrogen-Ion Concentration Male Measurement methods Mice, Inbred C57BL multidisciplinary Neurotransmitters pH effects Photic Stimulation Protons Regional development Science Science (multidisciplinary) Sensors Spatio-Temporal Analysis Stimulation Temporal lobe Temporal resolution Visual cortex Visual Cortex - diagnostic imaging Visual Cortex - physiology Visual stimuli
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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