CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain

Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dynamics in the brain, the development of a device with both wide-area detectability and high spatial-ltemporal resolution is necessary....

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Veröffentlicht in:	Nature communications Jg. 11; H. 1; S. 712 - 9
Hauptverfasser:	Horiuchi, Hiroshi, Agetsuma, Masakazu, Ishida, Junko, Nakamura, Yusuke, Lawrence Cheung, Dennis, Nanasaki, Shin, Kimura, Yasuyuki, Iwata, Tatsuya, Takahashi, Kazuhiro, Sawada, Kazuaki, Nabekura, Junichi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 05.02.2020 Nature Publishing Group Nature Portfolio
Schlagworte:	631/1647/1888 631/1647/245 9/10 Animal models Animals Biosensing Techniques - instrumentation Biosensing Techniques - methods Biosensors Brain Brain - diagnostic imaging Brain - physiology Brain Chemistry Change detection CMOS Equipment Design Humanities and Social Sciences Hydrogen-Ion Concentration Male Measurement methods Mice, Inbred C57BL multidisciplinary Neurotransmitters pH effects Photic Stimulation Protons Regional development Science Science (multidisciplinary) Sensors Spatio-Temporal Analysis Stimulation Temporal lobe Temporal resolution Visual cortex Visual Cortex - diagnostic imaging Visual Cortex - physiology Visual stimuli
ISSN:	2041-1723, 2041-1723
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Abstract	Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dynamics in the brain, the development of a device with both wide-area detectability and high spatial-ltemporal resolution is necessary. Therefore, we develop an image sensor with a high spatial-temporal resolution specifically designed for measuring protons in vivo. Here, we demonstrate that spatially deferent neural stimulation by visual stimulation induced distinct patterns of proton changes in the visual cortex. This result indicates that our biosensor can detect micrometer and millisecond scale changes of protons across a wide area. Our study demonstrates that a CMOS-based proton image sensor with high spatial and temporal precision can be used to detect pH changes associated with biological events. We believe that our sensor may have broad applicability in future biological studies. Protons have been discovered to play a role in neuronal signaling, but current methods to measure pH in the brain of animal models are limited. Here the authors develop a miniaturized proton image sensor that fits into a living mouse brain and can measure pH changes at micrometer and millisecond resolution scales.
AbstractList	Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dynamics in the brain, the development of a device with both wide-area detectability and high spatial-ltemporal resolution is necessary. Therefore, we develop an image sensor with a high spatial-temporal resolution specifically designed for measuring protons in vivo. Here, we demonstrate that spatially deferent neural stimulation by visual stimulation induced distinct patterns of proton changes in the visual cortex. This result indicates that our biosensor can detect micrometer and millisecond scale changes of protons across a wide area. Our study demonstrates that a CMOS-based proton image sensor with high spatial and temporal precision can be used to detect pH changes associated with biological events. We believe that our sensor may have broad applicability in future biological studies. Protons have been discovered to play a role in neuronal signaling, but current methods to measure pH in the brain of animal models are limited. Here the authors develop a miniaturized proton image sensor that fits into a living mouse brain and can measure pH changes at micrometer and millisecond resolution scales. Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dynamics in the brain, the development of a device with both wide-area detectability and high spatial-ltemporal resolution is necessary. Therefore, we develop an image sensor with a high spatial-temporal resolution specifically designed for measuring protons in vivo. Here, we demonstrate that spatially deferent neural stimulation by visual stimulation induced distinct patterns of proton changes in the visual cortex. This result indicates that our biosensor can detect micrometer and millisecond scale changes of protons across a wide area. Our study demonstrates that a CMOS-based proton image sensor with high spatial and temporal precision can be used to detect pH changes associated with biological events. We believe that our sensor may have broad applicability in future biological studies. Protons have been discovered to play a role in neuronal signaling, but current methods to measure pH in the brain of animal models are limited. Here the authors develop a miniaturized proton image sensor that fits into a living mouse brain and can measure pH changes at micrometer and millisecond resolution scales. Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dynamics in the brain, the development of a device with both wide-area detectability and high spatial-ltemporal resolution is necessary. Therefore, we develop an image sensor with a high spatial-temporal resolution specifically designed for measuring protons in vivo. Here, we demonstrate that spatially deferent neural stimulation by visual stimulation induced distinct patterns of proton changes in the visual cortex. This result indicates that our biosensor can detect micrometer and millisecond scale changes of protons across a wide area. Our study demonstrates that a CMOS-based proton image sensor with high spatial and temporal precision can be used to detect pH changes associated with biological events. We believe that our sensor may have broad applicability in future biological studies.Protons have been discovered to play a role in neuronal signaling, but current methods to measure pH in the brain of animal models are limited. Here the authors develop a miniaturized proton image sensor that fits into a living mouse brain and can measure pH changes at micrometer and millisecond resolution scales. Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dynamics in the brain, the development of a device with both wide-area detectability and high spatial-ltemporal resolution is necessary. Therefore, we develop an image sensor with a high spatial-temporal resolution specifically designed for measuring protons in vivo. Here, we demonstrate that spatially deferent neural stimulation by visual stimulation induced distinct patterns of proton changes in the visual cortex. This result indicates that our biosensor can detect micrometer and millisecond scale changes of protons across a wide area. Our study demonstrates that a CMOS-based proton image sensor with high spatial and temporal precision can be used to detect pH changes associated with biological events. We believe that our sensor may have broad applicability in future biological studies.Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent proton dynamics in the brain, the development of a device with both wide-area detectability and high spatial-ltemporal resolution is necessary. Therefore, we develop an image sensor with a high spatial-temporal resolution specifically designed for measuring protons in vivo. Here, we demonstrate that spatially deferent neural stimulation by visual stimulation induced distinct patterns of proton changes in the visual cortex. This result indicates that our biosensor can detect micrometer and millisecond scale changes of protons across a wide area. Our study demonstrates that a CMOS-based proton image sensor with high spatial and temporal precision can be used to detect pH changes associated with biological events. We believe that our sensor may have broad applicability in future biological studies.
ArticleNumber	712
Author	Iwata, Tatsuya Horiuchi, Hiroshi Agetsuma, Masakazu Nakamura, Yusuke Lawrence Cheung, Dennis Kimura, Yasuyuki Nabekura, Junichi Sawada, Kazuaki Takahashi, Kazuhiro Ishida, Junko Nanasaki, Shin
Author_xml	– sequence: 1 givenname: Hiroshi orcidid: 0000-0001-9008-2027 surname: Horiuchi fullname: Horiuchi, Hiroshi organization: Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Department of Physiological Sciences, SOKENDAI: The Graduate University for Advanced Studies – sequence: 2 givenname: Masakazu orcidid: 0000-0002-8606-4886 surname: Agetsuma fullname: Agetsuma, Masakazu organization: Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences – sequence: 3 givenname: Junko orcidid: 0000-0001-9794-0856 surname: Ishida fullname: Ishida, Junko organization: Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences – sequence: 4 givenname: Yusuke surname: Nakamura fullname: Nakamura, Yusuke organization: Department of Electrical and Electronic Engineering, Toyohashi University of Technology – sequence: 5 givenname: Dennis orcidid: 0000-0003-3795-6375 surname: Lawrence Cheung fullname: Lawrence Cheung, Dennis organization: Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences – sequence: 6 givenname: Shin surname: Nanasaki fullname: Nanasaki, Shin organization: Department of Electrical and Electronic Engineering, Toyohashi University of Technology – sequence: 7 givenname: Yasuyuki orcidid: 0000-0002-2072-8598 surname: Kimura fullname: Kimura, Yasuyuki organization: Department of Electrical and Electronic Engineering, Toyohashi University of Technology – sequence: 8 givenname: Tatsuya orcidid: 0000-0002-9846-297X surname: Iwata fullname: Iwata, Tatsuya organization: Department of Electrical and Electronic Engineering, Toyohashi University of Technology – sequence: 9 givenname: Kazuhiro surname: Takahashi fullname: Takahashi, Kazuhiro organization: Department of Electrical and Electronic Engineering, Toyohashi University of Technology – sequence: 10 givenname: Kazuaki surname: Sawada fullname: Sawada, Kazuaki email: sawada@ee.tut.ac.jp organization: Department of Electrical and Electronic Engineering, Toyohashi University of Technology – sequence: 11 givenname: Junichi surname: Nabekura fullname: Nabekura, Junichi email: nabekura@nips.ac.jp organization: Division of Homeostatic Development, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Department of Physiological Sciences, SOKENDAI: The Graduate University for Advanced Studies
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Snippet	Recent studies have shown that protons can function as neurotransmitters in cultured neurons. To further investigate regional and neural activity-dependent... Protons have been discovered to play a role in neuronal signaling, but current methods to measure pH in the brain of animal models are limited. Here the...
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SubjectTerms	631/1647/1888 631/1647/245 9/10 Animal models Animals Biosensing Techniques - instrumentation Biosensing Techniques - methods Biosensors Brain Brain - diagnostic imaging Brain - physiology Brain Chemistry Change detection CMOS Equipment Design Humanities and Social Sciences Hydrogen-Ion Concentration Male Measurement methods Mice, Inbred C57BL multidisciplinary Neurotransmitters pH effects Photic Stimulation Protons Regional development Science Science (multidisciplinary) Sensors Spatio-Temporal Analysis Stimulation Temporal lobe Temporal resolution Visual cortex Visual Cortex - diagnostic imaging Visual Cortex - physiology Visual stimuli
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Title	CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain
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