Quantification of mitochondrial DNA damage and copy number in circulating blood of patients with systemic sclerosis by a qPCR-based assay

Although not fully understood, oxidative stress has been implicated in the pathogenesis of different autoimmune diseases such as systemic sclerosis. Accumulating evidence indicates that oxidative stress can induce mitochondrial DNA (mtDNA) damage and variations in mtDNA copy number (mtDNAcn). The ai...

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Veröffentlicht in:	Anais brasileiros de dermatología Jg. 95; H. 3; S. 314 - 319
Hauptverfasser:	Movassaghi, Shafieh, Jafari, Sara, Falahati, Kowsar, Ataei, Mitra, Sanati, Mohammad Hossein, Jadali, Zohreh
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Spain Elsevier España, S.L.U 01.05.2020 Sociedade Brasileira de Dermatologia
Schlagworte:	Adult Autoimmunity Case-Control Studies DERMATOLOGY DNA DNA Copy Number Variations DNA Damage DNA, Mitochondrial - blood DNA, Mitochondrial - genetics Electrophoresis, Agar Gel Female Humans Investigation Male Middle Aged Mitochondrial Oxidative stress Oxidative Stress - genetics Reactive Oxygen Species - blood Real-Time Polymerase Chain Reaction Reference Values Scleroderma Scleroderma, Systemic - blood Scleroderma, Systemic - genetics Statistics, Nonparametric Systemic Autoimmunity Oxidative stress Mitochondrial DNA Systemic Scleroderma Real-time polymerase chain reaction
ISSN:	0365-0596, 1806-4841, 1806-4841
Online-Zugang:	Volltext
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