The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

UK Biobank is a population-based cohort of half a million participants aged 40–69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world’s largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resona...

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Vydáno v:Nature communications Ročník 11; číslo 1; s. 2624 - 12
Hlavní autoři: Littlejohns, Thomas J., Holliday, Jo, Gibson, Lorna M., Garratt, Steve, Oesingmann, Niels, Alfaro-Almagro, Fidel, Bell, Jimmy D., Boultwood, Chris, Collins, Rory, Conroy, Megan C., Crabtree, Nicola, Doherty, Nicola, Frangi, Alejandro F., Harvey, Nicholas C., Leeson, Paul, Miller, Karla L., Neubauer, Stefan, Petersen, Steffen E., Sellors, Jonathan, Sheard, Simon, Smith, Stephen M., Sudlow, Cathie L. M., Matthews, Paul M., Allen, Naomi E.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 26.05.2020
Nature Publishing Group
Nature Portfolio
Témata:
631/1647/245
692/308
Adult
Aged
Biobanks
Biological Specimen Banks - organization & administration
Brain
Data collection
Dual energy X-ray absorptiometry
Female
Humanities and Social Sciences
Humans
Image Enhancement - methods
Image Enhancement - standards
Incidental Findings
Information Management
Magnetic resonance imaging
Male
Medical imaging
Middle Aged
multidisciplinary
Multimodal Imaging
Neuroimaging
Review
Review Article
Science
Science (multidisciplinary)
Ultrasonic imaging
Ultrasound
United Kingdom
X ray imagery
United Kingdom
United Kingdom > UK
ISSN:2041-1723, 2041-1723
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Popis
Shrnutí:UK Biobank is a population-based cohort of half a million participants aged 40–69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world’s largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions. Between 2014 and 2023, 100,000 UK Biobank participants are undergoing brain, heart and abdominal MRI, as well as DXA and carotid ultrasound scans. In this review, authors provide a detailed overview of the rationale for the collection of these imaging data, the procedures of data collection and management, and the future directions of the UK biobank imaging enhancement.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-020-15948-9