Genetic regulation of gene expression and splicing during a 10-year period of human aging

Background Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there has been no long-term, longitudinal characterization of thes...

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Vydáno v:	Genome Biology Ročník 20; číslo 1; s. 230
Hlavní autoři:	Balliu, Brunilda, Durrant, Matthew, Goede, Olivia de, Abell, Nathan, Li, Xin, Liu, Boxiang, Gloudemans, Michael J., Cook, Naomi L., Smith, Kevin S., Knowles, David A., Pala, Mauro, Cucca, Francesco, Schlessinger, David, Jaiswal, Siddhartha, Sabatti, Chiara, Lind, Lars, Ingelsson, Erik, Montgomery, Stephen B.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 04.11.2019 Springer Nature B.V BMC
Témata:	Age Aged Aged, 80 and over Aging Aging - genetics Aging - metabolism Alternative Splicing Animal Genetics and Genomics Bioinformatics Biomedical and Life Sciences blood Blood pressure Cholesterol Disease Evolutionary Biology Female Gene expression Gene Expression Regulation Gene regulation genome Human Genetics Humans Life Sciences Longevity Longitudinal studies Male Metabolism Microbial Genetics and Genomics Plant Genetics and Genomics RNA transcriptome Transcriptomes variance Aging Alternative splicing Longevity Gene expression Gene regulation
ISSN:	1474-760X, 1474-7596, 1465-6906, 1474-760X
On-line přístup:	Získat plný text
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