Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

Polygenic Scores (PSs) describe the genetic component of an individual’s quantitative phenotype or their susceptibility to diseases with a genetic basis. Currently, PSs rely on population-dependent contributions of many associated alleles, with limited applicability to understudied populations and r...

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Vydané v:	Nature communications Ročník 11; číslo 1; s. 1628 - 9
Hlavní autori:	Marnetto, Davide, Pärna, Katri, Läll, Kristi, Molinaro, Ludovica, Montinaro, Francesco, Haller, Toomas, Metspalu, Mait, Mägi, Reedik, Fischer, Krista, Pagani, Luca
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 02.04.2020 Nature Publishing Group Nature Portfolio
Predmet:	631/114/2413 631/208/205 631/208/457/649 Bias Deconvolution Genealogy Genetic Predisposition to Disease Genetics, Population Genomes Genotype Humanities and Social Sciences Humans Models, Genetic multidisciplinary Multifactorial Inheritance Phenotype Phenotypes Polygenic inheritance Population Population genetics Populations Precision medicine Predictions Science Science (multidisciplinary)
ISSN:	2041-1723, 2041-1723
On-line prístup:	Získať plný text
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