Tissue-specific multi-omics analysis of atrial fibrillation

Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences for mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed for decipher...

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Veröffentlicht in:	Nature communications Jg. 13; H. 1; S. 441 - 15
Hauptverfasser:	Assum, Ines, Krause, Julia, Scheinhardt, Markus O., Müller, Christian, Hammer, Elke, Börschel, Christin S., Völker, Uwe, Conradi, Lenard, Geelhoed, Bastiaan, Zeller, Tanja, Schnabel, Renate B., Heinig, Matthias
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 21.01.2022 Nature Publishing Group Nature Portfolio
Schlagworte:	631/114/2114 631/208/199 631/208/205/2138 631/208/212 631/45/475 Atria Atrial Fibrillation - genetics Cardiac arrhythmia Cardiovascular diseases Fibrillation Gene expression Gene Expression Regulation Genetic diversity Genetic Predisposition to Disease Genetic variance Genome-wide association studies Genome-Wide Association Study Genomics Homeobox Protein Nkx-2.5 - genetics Homeobox Protein Nkx-2.5 - metabolism Humanities and Social Sciences Humans Molecular modelling multidisciplinary Nkx2.5 protein Organ Specificity Polymorphism, Single Nucleotide - genetics Proteins Proteomics Quantitative trait loci Quantitative Trait Loci - genetics Science Science (multidisciplinary) Single-nucleotide polymorphism Transcriptomics
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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