Tissue-specific multi-omics analysis of atrial fibrillation

Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences for mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed for decipher...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature communications Jg. 13; H. 1; S. 441 - 15
Hauptverfasser: Assum, Ines, Krause, Julia, Scheinhardt, Markus O., Müller, Christian, Hammer, Elke, Börschel, Christin S., Völker, Uwe, Conradi, Lenard, Geelhoed, Bastiaan, Zeller, Tanja, Schnabel, Renate B., Heinig, Matthias
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 21.01.2022
Nature Publishing Group
Nature Portfolio
Schlagworte:
631/114/2114
631/208/199
631/208/205/2138
631/208/212
631/45/475
Atria
Atrial Fibrillation - genetics
Cardiac arrhythmia
Cardiovascular diseases
Fibrillation
Gene expression
Gene Expression Regulation
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
Genome-wide association studies
Genome-Wide Association Study
Genomics
Homeobox Protein Nkx-2.5 - genetics
Homeobox Protein Nkx-2.5 - metabolism
Humanities and Social Sciences
Humans
Molecular modelling
multidisciplinary
Nkx2.5 protein
Organ Specificity
Polymorphism, Single Nucleotide - genetics
Proteins
Proteomics
Quantitative trait loci
Quantitative Trait Loci - genetics
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
Transcriptomics
ISSN:2041-1723, 2041-1723
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences for mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed for deciphering the underlying molecular networks. Here, we integrate genomics, transcriptomics, and proteomics of human atrial tissue in a cross-sectional study to identify widespread effects of genetic variants on both transcript ( cis -eQTL) and protein ( cis -pQTL) abundance. We further establish a novel targeted trans -QTL approach based on polygenic risk scores to determine candidates for AF core genes. Using this approach, we identify two trans -eQTLs and five trans -pQTLs for AF GWAS hits, and elucidate the role of the transcription factor NKX2-5 as a link between the GWAS SNP rs9481842 and AF. Altogether, we present an integrative multi-omics method to uncover trans -acting networks in small datasets and provide a rich resource of atrial tissue-specific regulatory variants for transcript and protein levels for cardiovascular disease gene prioritization. Numerous disease-associated variants have been described in GWAS for atrial fibrillation. Here the authors integrate omics data to investigate the consequences of genetic variants for transcript and protein levels in the atrium of the human heart. With this multi-omics approach, authors reveal the regulatory network underlying atrial fibrillation and provide a resource for cardiac gene prioritization.
AbstractList Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences for mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed for deciphering the underlying molecular networks. Here, we integrate genomics, transcriptomics, and proteomics of human atrial tissue in a cross-sectional study to identify widespread effects of genetic variants on both transcript (cis-eQTL) and protein (cis-pQTL) abundance. We further establish a novel targeted trans-QTL approach based on polygenic risk scores to determine candidates for AF core genes. Using this approach, we identify two trans-eQTLs and five trans-pQTLs for AF GWAS hits, and elucidate the role of the transcription factor NKX2-5 as a link between the GWAS SNP rs9481842 and AF. Altogether, we present an integrative multi-omics method to uncover trans-acting networks in small datasets and provide a rich resource of atrial tissue-specific regulatory variants for transcript and protein levels for cardiovascular disease gene prioritization. Numerous disease-associated variants have been described in GWAS for atrial fibrillation. Here the authors integrate omics data to investigate the consequences of genetic variants for transcript and protein levels in the atrium of the human heart. With this multi-omics approach, authors reveal the regulatory network underlying atrial fibrillation and provide a resource for cardiac gene prioritization.
Numerous disease-associated variants have been described in GWAS for atrial fibrillation. Here the authors integrate omics data to investigate the consequences of genetic variants for transcript and protein levels in the atrium of the human heart. With this multi-omics approach, authors reveal the regulatory network underlying atrial fibrillation and provide a resource for cardiac gene prioritization.
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences for mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed for deciphering the underlying molecular networks. Here, we integrate genomics, transcriptomics, and proteomics of human atrial tissue in a cross-sectional study to identify widespread effects of genetic variants on both transcript ( cis -eQTL) and protein ( cis -pQTL) abundance. We further establish a novel targeted trans -QTL approach based on polygenic risk scores to determine candidates for AF core genes. Using this approach, we identify two trans -eQTLs and five trans -pQTLs for AF GWAS hits, and elucidate the role of the transcription factor NKX2-5 as a link between the GWAS SNP rs9481842 and AF. Altogether, we present an integrative multi-omics method to uncover trans -acting networks in small datasets and provide a rich resource of atrial tissue-specific regulatory variants for transcript and protein levels for cardiovascular disease gene prioritization. Numerous disease-associated variants have been described in GWAS for atrial fibrillation. Here the authors integrate omics data to investigate the consequences of genetic variants for transcript and protein levels in the atrium of the human heart. With this multi-omics approach, authors reveal the regulatory network underlying atrial fibrillation and provide a resource for cardiac gene prioritization.
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences for mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed for deciphering the underlying molecular networks. Here, we integrate genomics, transcriptomics, and proteomics of human atrial tissue in a cross-sectional study to identify widespread effects of genetic variants on both transcript (cis-eQTL) and protein (cis-pQTL) abundance. We further establish a novel targeted trans-QTL approach based on polygenic risk scores to determine candidates for AF core genes. Using this approach, we identify two trans-eQTLs and five trans-pQTLs for AF GWAS hits, and elucidate the role of the transcription factor NKX2-5 as a link between the GWAS SNP rs9481842 and AF. Altogether, we present an integrative multi-omics method to uncover trans-acting networks in small datasets and provide a rich resource of atrial tissue-specific regulatory variants for transcript and protein levels for cardiovascular disease gene prioritization.Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences for mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed for deciphering the underlying molecular networks. Here, we integrate genomics, transcriptomics, and proteomics of human atrial tissue in a cross-sectional study to identify widespread effects of genetic variants on both transcript (cis-eQTL) and protein (cis-pQTL) abundance. We further establish a novel targeted trans-QTL approach based on polygenic risk scores to determine candidates for AF core genes. Using this approach, we identify two trans-eQTLs and five trans-pQTLs for AF GWAS hits, and elucidate the role of the transcription factor NKX2-5 as a link between the GWAS SNP rs9481842 and AF. Altogether, we present an integrative multi-omics method to uncover trans-acting networks in small datasets and provide a rich resource of atrial tissue-specific regulatory variants for transcript and protein levels for cardiovascular disease gene prioritization.
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences for mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed for deciphering the underlying molecular networks. Here, we integrate genomics, transcriptomics, and proteomics of human atrial tissue in a cross-sectional study to identify widespread effects of genetic variants on both transcript ( cis -eQTL) and protein ( cis -pQTL) abundance. We further establish a novel targeted trans -QTL approach based on polygenic risk scores to determine candidates for AF core genes. Using this approach, we identify two trans -eQTLs and five trans -pQTLs for AF GWAS hits, and elucidate the role of the transcription factor NKX2-5 as a link between the GWAS SNP rs9481842 and AF. Altogether, we present an integrative multi-omics method to uncover trans -acting networks in small datasets and provide a rich resource of atrial tissue-specific regulatory variants for transcript and protein levels for cardiovascular disease gene prioritization.
Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms, especially consequences for mRNA and protein expression remain largely elusive. Thus, refined multi-omics approaches are needed for deciphering the underlying molecular networks. Here, we integrate genomics, transcriptomics, and proteomics of human atrial tissue in a cross-sectional study to identify widespread effects of genetic variants on both transcript (cis-eQTL) and protein (cis-pQTL) abundance. We further establish a novel targeted trans-QTL approach based on polygenic risk scores to determine candidates for AF core genes. Using this approach, we identify two trans-eQTLs and five trans-pQTLs for AF GWAS hits, and elucidate the role of the transcription factor NKX2-5 as a link between the GWAS SNP rs9481842 and AF. Altogether, we present an integrative multi-omics method to uncover trans-acting networks in small datasets and provide a rich resource of atrial tissue-specific regulatory variants for transcript and protein levels for cardiovascular disease gene prioritization.
ArticleNumber 441
Author Geelhoed, Bastiaan
Müller, Christian
Zeller, Tanja
Scheinhardt, Markus O.
Hammer, Elke
Assum, Ines
Krause, Julia
Schnabel, Renate B.
Börschel, Christin S.
Heinig, Matthias
Völker, Uwe
Conradi, Lenard
Author_xml – sequence: 1
  givenname: Ines
  orcidid: 0000-0003-3347-6235
  surname: Assum
  fullname: Assum, Ines
  organization: Computational Health Center, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Department of Informatics, Technical University Munich
– sequence: 2
  givenname: Julia
  surname: Krause
  fullname: Krause, Julia
  organization: University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg, Partner site Hamburg/Kiel/Lübeck, DZHK (German Center for Cardiovascular Research)
– sequence: 3
  givenname: Markus O.
  surname: Scheinhardt
  fullname: Scheinhardt, Markus O.
  organization: Institute of Medical Biometry and Statistics, University of Lübeck, University Hospital of Schleswig-Holstein
– sequence: 4
  givenname: Christian
  surname: Müller
  fullname: Müller, Christian
  organization: University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg, Partner site Hamburg/Kiel/Lübeck, DZHK (German Center for Cardiovascular Research)
– sequence: 5
  givenname: Elke
  surname: Hammer
  fullname: Hammer, Elke
  organization: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Partner site Greifswald, DZHK (German Center for Cardiovascular Research)
– sequence: 6
  givenname: Christin S.
  surname: Börschel
  fullname: Börschel, Christin S.
  organization: Partner site Hamburg/Kiel/Lübeck, DZHK (German Center for Cardiovascular Research), Department of Cardiology, University Heart and Vascular Center Hamburg
– sequence: 7
  givenname: Uwe
  orcidid: 0000-0002-5689-3448
  surname: Völker
  fullname: Völker, Uwe
  organization: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Partner site Greifswald, DZHK (German Center for Cardiovascular Research)
– sequence: 8
  givenname: Lenard
  surname: Conradi
  fullname: Conradi, Lenard
  organization: Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg
– sequence: 9
  givenname: Bastiaan
  surname: Geelhoed
  fullname: Geelhoed, Bastiaan
  organization: Partner site Hamburg/Kiel/Lübeck, DZHK (German Center for Cardiovascular Research), Department of Cardiology, University Heart and Vascular Center Hamburg, Department of Cardiology, University of Groningen, University Medical Center Groningen
– sequence: 10
  givenname: Tanja
  surname: Zeller
  fullname: Zeller, Tanja
  organization: University Center of Cardiovascular Science, University Heart and Vascular Center Hamburg, Partner site Hamburg/Kiel/Lübeck, DZHK (German Center for Cardiovascular Research)
– sequence: 11
  givenname: Renate B.
  orcidid: 0000-0001-7170-9509
  surname: Schnabel
  fullname: Schnabel, Renate B.
  email: r.schnabel@uke.de
  organization: Partner site Hamburg/Kiel/Lübeck, DZHK (German Center for Cardiovascular Research), Department of Cardiology, University Heart and Vascular Center Hamburg
– sequence: 12
  givenname: Matthias
  orcidid: 0000-0002-5612-1720
  surname: Heinig
  fullname: Heinig, Matthias
  email: matthias.heinig@helmholtz-muenchen.de
  organization: Computational Health Center, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Department of Informatics, Technical University Munich, Partner site Munich, DZHK (German Center for Cardiovascular Research)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35064145$$D View this record in MEDLINE/PubMed
BookMark eNp9Uk1rFTEUDVKxtfYPuJABN25S8zX5QBCkqC0U3Lx9uJNJnnnMTJ7JjNB_3_RNq20XzSYhOefcc2_OW3Q0pckj9J6Sc0q4_lwEFVJhwhhmyrQc01fohBFBMVWMHz06H6OzUnakLm6oFuINOuYtkZXfnqAvm1jK4nHZexdDdM24DHPEaYyuNDDBcFNiaVJoYM4RhibELsdhgDmm6R16HWAo_ux-P0WbH983F5f4-tfPq4tv19hJImesdQ8yONWDl8CJ7hkE4NArI4iQTlIFChyhjvPAhBHMG06D6YL3SlHBT9HVKtsn2Nl9jiPkG5sg2sNFylsLeY5u8La2FbTxnAlohTTGAA-E1m5F33nX8ar1ddXaL93oe-enOcPwRPTpyxR_2236a7XSTBtTBT7dC-T0Z_FltmMszteJTD4txTLJGNPCqLtaH59Bd2nJdaQHFNWMCtpW1IfHjv5ZefiiCtArwOVUSvbBujgf5l8NxsFSYu8CYddA2BoIewiEpZXKnlEf1F8k8ZVUKnja-vzf9gusW-eLxxM
CitedBy_id crossref_primary_10_1186_s40246_025_00718_9
crossref_primary_10_1111_eci_14135
crossref_primary_10_1016_j_isci_2024_110660
crossref_primary_10_3389_fphar_2024_1497977
crossref_primary_10_3390_biomedicines11102632
crossref_primary_10_1038_s41591_025_03872_8
crossref_primary_10_1093_cvr_cvae169
crossref_primary_10_1371_journal_pone_0323534
crossref_primary_10_1093_cvr_cvaf023
crossref_primary_10_3389_fcvm_2023_1198486
crossref_primary_10_3389_fimmu_2023_1069379
crossref_primary_10_1016_j_hrthm_2024_06_005
crossref_primary_10_1371_journal_pone_0324324
crossref_primary_10_3390_ijms242417244
crossref_primary_10_1016_j_tips_2023_06_010
crossref_primary_10_3390_biomedicines13030654
crossref_primary_10_59717_j_xinn_med_2025_100154
crossref_primary_10_1007_s12350_023_03248_w
crossref_primary_10_1016_j_bja_2023_03_006
crossref_primary_10_2147_JIR_S438701
crossref_primary_10_3390_ijms24054264
Cites_doi 10.1161/CIRCRESAHA.119.315686
10.1371/journal.pgen.1004383
10.7554/eLife.05005
10.1016/j.cell.2019.04.014
10.1186/s13059-017-1286-z
10.1016/j.jacc.2007.09.055
10.3892/ijmm.2013.1316
10.1093/nar/gky1120
10.1038/ncomms7326
10.1038/s41586-018-0175-2
10.1002/sim.3034
10.1038/nature12531
10.1093/nar/gky955
10.1093/bioinformatics/btu779
10.7554/eLife.35788
10.1074/jbc.M112.377713
10.1038/s41467-018-05512-x
10.1093/database/bar030
10.1093/bioinformatics/btp328
10.1016/j.yjmcc.2015.06.005
10.1016/j.jacc.2004.08.058
10.1093/bioinformatics/btp616
10.1038/s41467-017-01747-2
10.1016/j.ajhg.2014.07.005
10.1093/eurheartj/ehw210
10.1093/nar/gkx1081
10.1073/pnas.1530509100
10.1093/nar/gkx1092
10.1093/cvr/cvw007
10.1016/j.pharmthera.2005.03.005
10.1038/s41467-018-03714-x
10.1371/journal.pgen.1000529
10.1161/CIRCRESAHA.119.315179
10.1038/nprot.2010.116
10.1038/s41588-018-0171-3
10.1038/s41588-018-0183-z
10.1161/JAHA.115.001808
10.1093/hmg/ddu328
10.1038/ncomms14357
10.1186/s13059-016-0974-4
10.1038/ncomms11303
10.1016/j.jcjd.2018.05.007
10.3389/fcvm.2016.00025
10.3389/fgene.2019.00806
10.1038/s41588-019-0499-3
10.1161/CIRCGENETICS.117.001974
10.1371/journal.pcbi.1003118
10.1038/s41588-018-0154-4
10.1038/nature15394
10.1073/pnas.0506580102
10.1161/CIRCULATIONAHA.111.019893
10.1161/CIRCGENETICS.108.846733
10.1253/circj.CJ-13-1365
10.1126/science.1260793
10.1038/nprot.2011.457
10.3389/fcvm.2019.00127
10.1093/nar/gku1205
10.15252/msb.20188513
10.1038/nature15393
10.1093/nar/gky1055
10.1038/s41467-019-12721-5
10.3389/fgene.2018.00507
10.1152/physiolgenomics.00012.2019
10.1159/000496150
10.1038/nature11247
10.1093/bioinformatics/bts163
10.1038/s41588-018-0133-9
10.1093/bioinformatics/btq431
10.1016/j.cell.2016.03.014
10.1002/stem.1923
10.1038/ng.2756
10.1038/75556
10.1093/bioinformatics/btu393
10.5281/zenodo.5080229
10.7554/eLife.52155
10.5281/zenodo.5094276
ContentType Journal Article
Copyright The Author(s) 2022
2022. The Author(s).
The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2022
– notice: 2022. The Author(s).
– notice: The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-022-27953-1
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Journals
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central
Advanced Technologies & Computer Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological science database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

Publicly Available Content Database

MEDLINE - Academic
CrossRef
MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: Publicly Available Content Database (Proquest)
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 15
ExternalDocumentID oai_doaj_org_article_506f89e324a546999a3f013504dbecb3
PMC8782899
35064145
10_1038_s41467_022_27953_1
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)
  grantid: 01ZX1708G; 01ZX1408D
  funderid: https://doi.org/10.13039/501100002347
– fundername: ;
  grantid: 01ZX1708G; 01ZX1408D
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
AFFHD
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c606t-88da6fc7dae6a308d2afa3ad794046c617a7ac01c33f24942e931f9bfee77143
IEDL.DBID DOA
ISICitedReferencesCount 26
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000745537800009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2041-1723
IngestDate Fri Oct 03 12:44:05 EDT 2025
Tue Nov 04 01:44:58 EST 2025
Fri Sep 05 10:28:32 EDT 2025
Tue Oct 07 07:06:23 EDT 2025
Mon Jul 21 06:06:10 EDT 2025
Tue Nov 18 21:21:16 EST 2025
Sat Nov 29 06:29:40 EST 2025
Fri Feb 21 02:38:38 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2022. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c606t-88da6fc7dae6a308d2afa3ad794046c617a7ac01c33f24942e931f9bfee77143
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-5689-3448
0000-0001-7170-9509
0000-0003-3347-6235
0000-0002-5612-1720
OpenAccessLink https://doaj.org/article/506f89e324a546999a3f013504dbecb3
PMID 35064145
PQID 2621821415
PQPubID 546298
PageCount 15
ParticipantIDs doaj_primary_oai_doaj_org_article_506f89e324a546999a3f013504dbecb3
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8782899
proquest_miscellaneous_2622284973
proquest_journals_2621821415
pubmed_primary_35064145
crossref_citationtrail_10_1038_s41467_022_27953_1
crossref_primary_10_1038_s41467_022_27953_1
springer_journals_10_1038_s41467_022_27953_1
PublicationCentury 2000
PublicationDate 2022-01-21
PublicationDateYYYYMMDD 2022-01-21
PublicationDate_xml – month: 01
  year: 2022
  text: 2022-01-21
  day: 21
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2022
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Akazawa, Komuro (CR39) 2005; 107
Kanaan, Patten, Redpath, Harper (CR33) 2019; 43
Stegle, Parts, Piipari, Winn, Durbin (CR17) 2012; 7
Carbon (CR79) 2019; 47
Khera (CR6) 2018; 50
Gu, Gu, Eils, Schlesner, Brors (CR85) 2014; 30
Liu, Beyer, Aebersold (CR23) 2016; 165
Anderson (CR61) 2010; 5
Iwasaki, Nishida, Kato, Nattel (CR42) 2011; 124
Hause (CR21) 2014; 95
Dunham (CR74) 2012; 489
Giambartolomei (CR22) 2014; 10
Hershberger (CR29) 2009; 2
Thomas (CR36) 2019; 51
Lemire (CR10) 2015; 6
Auton (CR63) 2015; 526
Storey, Tibshirani (CR20) 2003; 100
Dorn (CR51) 2015; 33
Carvalho, Irizarry (CR65) 2010; 26
Lappalainen (CR18) 2013; 501
Wang (CR26) 2019; 10
Battle (CR14) 2015; 347
Robert, Pelletier (CR25) 2018; 9
Lawlor, Harbord, Sterne, Timpson, Smith (CR52) 2008; 27
Ghezelbash, Molina, Dobrev (CR43) 2015; 4
Wang, Wang (CR1) 2018; 6
El-Hattab, Scaglia (CR34) 2016; 3
CR48
Nielsen (CR4) 2018; 50
Kinsella (CR66) 2011; 2011
Westra (CR9) 2013; 45
Yao (CR16) 2018; 9
CR84
CR83
van Ouwerkerk (CR8) 2019; 10
McLaren (CR68) 2016; 17
Chèneby, Gheorghe, Artufel, Mathelier, Ballester (CR71) 2018; 46
Parvatiyar (CR47) 2012; 287
Tu, Zhou, Liu, Li, Liu (CR45) 2014; 78
Agarwal, Bell, Nam, Bartel (CR73) 2015; 4
Doll (CR30) 2017; 8
Subramanian (CR27) 2005; 102
Huang, Xue, Xu, Zhou, Yang (CR32) 2013; 31
Montefiori (CR70) 2018; 7
Suhre (CR13) 2017; 8
Kim (CR81) 2015; 22
Heinig (CR55) 2017; 18
Frankish (CR72) 2019; 47
Robinson, Mccarthy, Smyth (CR82) 2010; 26
Dalal, Sabe, Elmadhun, Ramlawi, Sellke (CR50) 2015; 30
Davis (CR75) 2018; 46
Gamazon (CR19) 2018; 50
CR58
Ashburner (CR78) 2000; 25
van der Wijst (CR80) 2020; 9
CR12
Amberger, Bocchini, Schiettecatte, Scott, Hamosh (CR35) 2015; 43
Jhaveri, Aziz, Saarel (CR31) 2018; 4
Mayr (CR56) 2008; 51
Lawrence (CR60) 2013; 9
Hayashi (CR49) 2004; 44
Arnold, Raffler, Pfeufer, Suhre, Kastenmüller (CR77) 2015; 31
Orr (CR44) 2016; 7
Choi (CR7) 2020; 126
Sutanto, Dobrev, Heijman (CR2) 2019; 24
Coats (CR46) 2018; 11
Sun (CR15) 2018; 558
Eraslan (CR24) 2019; 15
Anderson (CR37) 2018; 9
Howie, Donnelly, Marchini (CR62) 2009; 5
Roselli (CR3) 2018; 50
Opacic, Van Bragt, Nasrallah, Schotten, Verheule (CR41) 2016; 109
Kalsto, Siland, Rienstra, Christophersen (CR5) 2019; 6
Lawrence, Gentleman, Carey (CR59) 2009; 25
CR28
Kirchhof (CR54) 2016; 37
CR69
Sudmant (CR64) 2015; 526
Wang (CR40) 2020; 126
Shabalin (CR76) 2012; 28
Liu, Li, Pritchard (CR11) 2019; 177
Martin (CR57) 2015; 85
Smith, Hemani (CR53) 2014; 23
Buniello (CR67) 2019; 47
Benaglio (CR38) 2019; 51
M Heinig (27953_CR55) 2017; 18
BS Carvalho (27953_CR65) 2010; 26
A Frankish (27953_CR72) 2019; 47
M Lawrence (27953_CR59) 2009; 25
A Auton (27953_CR63) 2015; 526
JD Storey (27953_CR20) 2003; 100
27953_CR58
M Ashburner (27953_CR78) 2000; 25
27953_CR12
DJ Anderson (27953_CR37) 2018; 9
Z Gu (27953_CR85) 2014; 30
F Robert (27953_CR25) 2018; 9
CA Davis (27953_CR75) 2018; 46
ER Gamazon (27953_CR19) 2018; 50
T Tu (27953_CR45) 2014; 78
RS Dalal (27953_CR50) 2015; 30
S Carbon (27953_CR79) 2019; 47
V Agarwal (27953_CR73) 2015; 4
S Jhaveri (27953_CR31) 2018; 4
P Kirchhof (27953_CR54) 2016; 37
S Doll (27953_CR30) 2017; 8
H Akazawa (27953_CR39) 2005; 107
O Stegle (27953_CR17) 2012; 7
RI Martin (27953_CR57) 2015; 85
JS Amberger (27953_CR35) 2015; 43
CJ Coats (27953_CR46) 2018; 11
27953_CR48
I Dunham (27953_CR74) 2012; 489
N Orr (27953_CR44) 2016; 7
AA Shabalin (27953_CR76) 2012; 28
T Hayashi (27953_CR49) 2004; 44
27953_CR84
SH Choi (27953_CR7) 2020; 126
RJ Hause (27953_CR21) 2014; 95
MD Robinson (27953_CR82) 2010; 26
DA Lawlor (27953_CR52) 2008; 27
27953_CR83
AV Khera (27953_CR6) 2018; 50
C Roselli (27953_CR3) 2018; 50
Y Liu (27953_CR23) 2016; 165
RT Huang (27953_CR32) 2013; 31
LE Montefiori (27953_CR70) 2018; 7
T Lappalainen (27953_CR18) 2013; 501
RE Hershberger (27953_CR29) 2009; 2
K Suhre (27953_CR13) 2017; 8
Y Wang (27953_CR1) 2018; 6
Y Wang (27953_CR26) 2019; 10
M Lawrence (27953_CR60) 2013; 9
M Lemire (27953_CR10) 2015; 6
SM Kalsto (27953_CR5) 2019; 6
GN Kanaan (27953_CR33) 2019; 43
PH Sudmant (27953_CR64) 2015; 526
M Arnold (27953_CR77) 2015; 31
B Wang (27953_CR40) 2020; 126
M Mayr (27953_CR56) 2008; 51
RJ Kinsella (27953_CR66) 2011; 2011
AF van Ouwerkerk (27953_CR8) 2019; 10
C Yao (27953_CR16) 2018; 9
MS Parvatiyar (27953_CR47) 2012; 287
H Sutanto (27953_CR2) 2019; 24
T Dorn (27953_CR51) 2015; 33
27953_CR28
AM Thomas (27953_CR36) 2019; 51
A Subramanian (27953_CR27) 2005; 102
S Ghezelbash (27953_CR43) 2015; 4
HJ Westra (27953_CR9) 2013; 45
M van der Wijst (27953_CR80) 2020; 9
C Giambartolomei (27953_CR22) 2014; 10
B Eraslan (27953_CR24) 2019; 15
A Buniello (27953_CR67) 2019; 47
27953_CR69
AW El-Hattab (27953_CR34) 2016; 3
J Chèneby (27953_CR71) 2018; 46
D Opacic (27953_CR41) 2016; 109
X Liu (27953_CR11) 2019; 177
YK Iwasaki (27953_CR42) 2011; 124
S Kim (27953_CR81) 2015; 22
JB Nielsen (27953_CR4) 2018; 50
P Benaglio (27953_CR38) 2019; 51
GD Smith (27953_CR53) 2014; 23
BB Sun (27953_CR15) 2018; 558
BN Howie (27953_CR62) 2009; 5
W McLaren (27953_CR68) 2016; 17
A Battle (27953_CR14) 2015; 347
CA Anderson (27953_CR61) 2010; 5
References_xml – volume: 126
  start-page: 200
  year: 2020
  end-page: 209
  ident: CR7
  article-title: Monogenic and polygenic contributions to atrial
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.119.315686
– volume: 10
  start-page: e1004383
  year: 2014
  ident: CR22
  article-title: Bayesian test for colocalisation between pairs of genetic association studies using summary statistics
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1004383
– volume: 4
  start-page: e05005
  year: 2015
  ident: CR73
  article-title: Predicting effective microRNA target sites in mammalian mRNAs
  publication-title: eLife
  doi: 10.7554/eLife.05005
– volume: 177
  start-page: 1022
  year: 2019
  end-page: 1034
  ident: CR11
  article-title: Trans effects on gene expression can drive omnigenic inheritance
  publication-title: Cell
  doi: 10.1016/j.cell.2019.04.014
– volume: 18
  year: 2017
  ident: CR55
  article-title: Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy
  publication-title: Genome Biol.
  doi: 10.1186/s13059-017-1286-z
– volume: 51
  start-page: 585
  year: 2008
  end-page: 594
  ident: CR56
  article-title: Combined metabolomic and proteomic analysis of human atrial fibrillation
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2007.09.055
– volume: 31
  start-page: 1119
  year: 2013
  end-page: 1126
  ident: CR32
  article-title: A novel NKX2.5 loss-of-function mutation responsible for familial atrial fibrillation
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.2013.1316
– volume: 47
  start-page: D1005
  year: 2019
  end-page: D1012
  ident: CR67
  article-title: The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky1120
– volume: 6
  year: 2015
  ident: CR10
  article-title: Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7326
– ident: CR12
– volume: 558
  start-page: 73
  year: 2018
  end-page: 79
  ident: CR15
  article-title: Genomic atlas of the human plasma proteome
  publication-title: Nature
  doi: 10.1038/s41586-018-0175-2
– volume: 27
  start-page: 1133
  year: 2008
  end-page: 1163
  ident: CR52
  article-title: Mendelian randomization: using genes as instruments for making causal inferences in epidemiology
  publication-title: Stat. Med.
  doi: 10.1002/sim.3034
– volume: 501
  start-page: 506
  year: 2013
  end-page: 511
  ident: CR18
  article-title: Transcriptome and genome sequencing uncovers functional variation in humans
  publication-title: Nature
  doi: 10.1038/nature12531
– volume: 47
  start-page: D766
  year: 2019
  end-page: D773
  ident: CR72
  article-title: GENCODE reference annotation for the human and mouse genomes
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky955
– volume: 31
  start-page: 1334
  year: 2015
  end-page: 1336
  ident: CR77
  article-title: SNiPA: An interactive, genetic variant-centered annotation browser
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu779
– volume: 7
  start-page: e35788
  year: 2018
  ident: CR70
  article-title: A promoter interaction map for cardiovascular disease genetics
  publication-title: eLife
  doi: 10.7554/eLife.35788
– volume: 287
  start-page: 31845
  year: 2012
  end-page: 31855
  ident: CR47
  article-title: A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.377713
– volume: 9
  year: 2018
  ident: CR16
  article-title: Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05512-x
– ident: CR58
– volume: 2011
  start-page: bar030
  year: 2011
  ident: CR66
  article-title: Original article Ensembl BioMarts : a hub for data retrieval across taxonomic space
  publication-title: Database
  doi: 10.1093/database/bar030
– ident: CR84
– volume: 4
  start-page: 530
  year: 2018
  end-page: 533
  ident: CR31
  article-title: Expanding the electrical phenotype of NKX2-5 mutations: ventricular tachycardia, atrial fibrillation, and complete heart block within one family
  publication-title: Hear. Case Rep.
– volume: 25
  start-page: 1841
  year: 2009
  end-page: 1842
  ident: CR59
  article-title: Rtracklayer: An R package for interfacing with genome browsers
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp328
– volume: 85
  start-page: 207
  year: 2015
  end-page: 214
  ident: CR57
  article-title: Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2015.06.005
– volume: 44
  start-page: 2192
  year: 2004
  end-page: 2201
  ident: CR49
  article-title: Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2004.08.058
– volume: 26
  start-page: 139
  year: 2010
  end-page: 140
  ident: CR82
  article-title: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
– volume: 8
  year: 2017
  ident: CR30
  article-title: Region and cell-type resolved quantitative proteomic map of the human heart
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01747-2
– volume: 22
  start-page: 665
  year: 2015
  end-page: 674
  ident: CR81
  article-title: Ppcor: An R package for a fast calculation to semi-partial correlation coefficients
  publication-title: Commun. Stat. Appl. Methods
– volume: 95
  start-page: 194
  year: 2014
  end-page: 208
  ident: CR21
  article-title: Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2014.07.005
– volume: 37
  start-page: 2893
  year: 2016
  end-page: 2962
  ident: CR54
  article-title: 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehw210
– volume: 46
  start-page: D794
  year: 2018
  end-page: D801
  ident: CR75
  article-title: The Encyclopedia of DNA elements (ENCODE): data portal update
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1081
– volume: 100
  start-page: 9440
  year: 2003
  end-page: 9445
  ident: CR20
  article-title: Statistical significance for genomewide studies
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1530509100
– volume: 46
  start-page: D267
  year: 2018
  end-page: D275
  ident: CR71
  article-title: ReMap 2018: An updated atlas of regulatory regions from an integrative analysis of DNA-binding ChIP-seq experiments
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1092
– volume: 109
  start-page: 527
  year: 2016
  end-page: 541
  ident: CR41
  article-title: Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvw007
– volume: 107
  start-page: 252
  year: 2005
  end-page: 268
  ident: CR39
  article-title: Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2005.03.005
– volume: 9
  year: 2018
  ident: CR37
  article-title: NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03714-x
– volume: 5
  start-page: e1000529
  year: 2009
  ident: CR62
  article-title: A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000529
– volume: 126
  start-page: 350
  year: 2020
  end-page: 360
  ident: CR40
  article-title: Integrative omics approach to identifying genes associated with atrial fibrillation
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.119.315179
– volume: 24
  start-page: 14
  year: 2019
  end-page: 16
  ident: CR2
  article-title: Genome-wide association studies of atrial fibrillation: finding meaning in the life of risk loci
  publication-title: Int. J. Cardiol. Heart Vasc.
– volume: 5
  start-page: 1564
  year: 2010
  end-page: 1573
  ident: CR61
  article-title: Data quality control in genetic case-control association studies
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2010.116
– volume: 50
  start-page: 1234
  year: 2018
  end-page: 1239
  ident: CR4
  article-title: Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0171-3
– volume: 50
  start-page: 1219
  year: 2018
  end-page: 1224
  ident: CR6
  article-title: Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0183-z
– volume: 4
  start-page: e001808
  year: 2015
  ident: CR43
  article-title: Altered atrial metabolism: an underappreciated contributor to the initiation and progression of atrial fibrillation
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.115.001808
– volume: 23
  start-page: 89
  year: 2014
  end-page: 98
  ident: CR53
  article-title: Mendelian randomization: genetic anchors for causal inference in epidemiological studies
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddu328
– volume: 8
  year: 2017
  ident: CR13
  article-title: Connecting genetic risk to disease end points through the human blood plasma proteome
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14357
– volume: 17
  year: 2016
  ident: CR68
  article-title: The Ensembl variant effect predictor
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-0974-4
– volume: 7
  year: 2016
  ident: CR44
  article-title: A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11303
– volume: 43
  start-page: 67
  year: 2019
  end-page: 75
  ident: CR33
  article-title: Atrial fibrillation is associated with impaired atrial mitochondrial energetics and supercomplex formation in adults with type 2 diabetes
  publication-title: Can. J. Diabetes
  doi: 10.1016/j.jcjd.2018.05.007
– volume: 3
  start-page: 25
  year: 2016
  ident: CR34
  article-title: Mitochondrial cardiomyopathies
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2016.00025
– volume: 9
  start-page: 1
  year: 2020
  end-page: 21
  ident: CR80
  article-title: The single-cell eQTLGen consortium
  publication-title: eLife
– volume: 10
  start-page: 806
  year: 2019
  ident: CR26
  article-title: Comprehensive cis-regulation analysis of genetic variants in human lymphoblastoid cell lines
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2019.00806
– volume: 51
  start-page: 1506
  year: 2019
  end-page: 1517
  ident: CR38
  article-title: Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0499-3
– volume: 11
  start-page: e001974
  year: 2018
  ident: CR46
  article-title: Proteomic analysis of the myocardium in hypertrophic obstructive cardiomyopathy
  publication-title: Circ. Genomic Precis. Med.
  doi: 10.1161/CIRCGENETICS.117.001974
– volume: 9
  start-page: e1003118
  year: 2013
  ident: CR60
  article-title: Software for computing and annotating genomic ranges
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1003118
– volume: 50
  start-page: 956
  year: 2018
  end-page: 967
  ident: CR19
  article-title: Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0154-4
– volume: 526
  start-page: 75
  year: 2015
  end-page: 81
  ident: CR64
  article-title: An integrated map of structural variation in 2,504 human genomes
  publication-title: Nature
  doi: 10.1038/nature15394
– ident: CR69
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 15550
  ident: CR27
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 124
  start-page: 2264
  year: 2011
  end-page: 2274
  ident: CR42
  article-title: Atrial fibrillation pathophysiology: implications for management
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.111.019893
– ident: CR48
– volume: 2
  start-page: 306
  year: 2009
  end-page: 313
  ident: CR29
  article-title: Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy
  publication-title: Circ. Cardiovasc. Genet.
  doi: 10.1161/CIRCGENETICS.108.846733
– volume: 78
  start-page: 993
  year: 2014
  end-page: 1001
  ident: CR45
  article-title: Quantitative proteomics of changes in energy metabolism-related proteins in atrial tissue from valvular disease patients with permanent atrial fibrillation
  publication-title: Circ. J.
  doi: 10.1253/circj.CJ-13-1365
– volume: 347
  start-page: 664
  year: 2015
  end-page: 667
  ident: CR14
  article-title: Impact of regulatory variation from RNA to protein
  publication-title: Science
  doi: 10.1126/science.1260793
– volume: 7
  start-page: 500
  year: 2012
  end-page: 507
  ident: CR17
  article-title: Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2011.457
– volume: 6
  start-page: 127
  year: 2019
  ident: CR5
  article-title: Atrial fibrillation genetics update: toward clinical implementation
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2019.00127
– volume: 43
  start-page: D789
  year: 2015
  end-page: D798
  ident: CR35
  article-title: OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an Online catalog of human genes and genetic disorders
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku1205
– volume: 30
  start-page: 520
  year: 2015
  end-page: 532
  ident: CR50
  article-title: Atrial fibrillation, neurocognitive decline and gene expression after cardiopulmonary bypass
  publication-title: Rev. Bras. Cir. Cardiovasc.
– volume: 15
  start-page: e8513
  year: 2019
  ident: CR24
  article-title: Quantification and discovery of sequence determinants of protein-per-mRNA amount in 29 human tissues
  publication-title: Mol. Syst. Biol.
  doi: 10.15252/msb.20188513
– volume: 526
  start-page: 68
  year: 2015
  end-page: 74
  ident: CR63
  article-title: A global reference for human genetic variation
  publication-title: Nature
  doi: 10.1038/nature15393
– volume: 47
  start-page: D330
  year: 2019
  end-page: D338
  ident: CR79
  article-title: The Gene Ontology Resource: 20 years and still GOing strong
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky1055
– volume: 10
  year: 2019
  ident: CR8
  article-title: Identification of atrial fibrillation associated genes and functional non-coding variants
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12721-5
– volume: 9
  start-page: 507
  year: 2018
  ident: CR25
  article-title: Exploring the impact of single-nucleotide polymorphisms on translation
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2018.00507
– volume: 51
  start-page: 323
  year: 2019
  end-page: 332
  ident: CR36
  article-title: Differentially expressed genes for atrial fibrillation identified by rna sequencing from paired human left and right atrial appendages
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00012.2019
– volume: 6
  start-page: 169
  year: 2018
  end-page: 186
  ident: CR1
  article-title: Genome-wide association studies of hypertension and several other cardiovascular diseases
  publication-title: Pulse
  doi: 10.1159/000496150
– volume: 489
  start-page: 57
  year: 2012
  end-page: 74
  ident: CR74
  article-title: An integrated encyclopedia of DNA elements in the human genome
  publication-title: Nature
  doi: 10.1038/nature11247
– volume: 28
  start-page: 1353
  year: 2012
  end-page: 1358
  ident: CR76
  article-title: Matrix eQTL: Ultra fast eQTL analysis via large matrix operations
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts163
– volume: 50
  start-page: 1225
  year: 2018
  end-page: 1233
  ident: CR3
  article-title: Multi-ethnic genome-wide association study for atrial fibrillation
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0133-9
– volume: 26
  start-page: 2363
  year: 2010
  end-page: 2367
  ident: CR65
  article-title: A framework for oligonucleotide microarray preprocessing
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq431
– volume: 165
  start-page: 535
  year: 2016
  end-page: 550
  ident: CR23
  article-title: On the dependency of cellular protein levels on mRNA abundance
  publication-title: Cell
  doi: 10.1016/j.cell.2016.03.014
– ident: CR83
– ident: CR28
– volume: 33
  start-page: 1113
  year: 2015
  end-page: 1129
  ident: CR51
  article-title: Direct Nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity
  publication-title: Stem Cells
  doi: 10.1002/stem.1923
– volume: 45
  start-page: 1238
  year: 2013
  end-page: 1243
  ident: CR9
  article-title: Systematic identification of trans eQTLs as putative drivers of known disease associations
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2756
– volume: 25
  start-page: 25
  year: 2000
  end-page: 29
  ident: CR78
  article-title: Gene Ontology: Tool for the unification of biology
  publication-title: Nat. Genet.
  doi: 10.1038/75556
– volume: 30
  start-page: 2811
  year: 2014
  end-page: 2812
  ident: CR85
  article-title: Circlize implements and enhances circular visualization in R
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu393
– volume: 124
  start-page: 2264
  year: 2011
  ident: 27953_CR42
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.111.019893
– volume: 45
  start-page: 1238
  year: 2013
  ident: 27953_CR9
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2756
– volume: 4
  start-page: e05005
  year: 2015
  ident: 27953_CR73
  publication-title: eLife
  doi: 10.7554/eLife.05005
– volume: 287
  start-page: 31845
  year: 2012
  ident: 27953_CR47
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.377713
– volume: 47
  start-page: D1005
  year: 2019
  ident: 27953_CR67
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky1120
– volume: 50
  start-page: 1234
  year: 2018
  ident: 27953_CR4
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0171-3
– volume: 558
  start-page: 73
  year: 2018
  ident: 27953_CR15
  publication-title: Nature
  doi: 10.1038/s41586-018-0175-2
– volume: 10
  start-page: e1004383
  year: 2014
  ident: 27953_CR22
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1004383
– volume: 9
  start-page: 507
  year: 2018
  ident: 27953_CR25
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2018.00507
– volume: 526
  start-page: 68
  year: 2015
  ident: 27953_CR63
  publication-title: Nature
  doi: 10.1038/nature15393
– volume: 489
  start-page: 57
  year: 2012
  ident: 27953_CR74
  publication-title: Nature
  doi: 10.1038/nature11247
– volume: 11
  start-page: e001974
  year: 2018
  ident: 27953_CR46
  publication-title: Circ. Genomic Precis. Med.
  doi: 10.1161/CIRCGENETICS.117.001974
– volume: 6
  year: 2015
  ident: 27953_CR10
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms7326
– volume: 78
  start-page: 993
  year: 2014
  ident: 27953_CR45
  publication-title: Circ. J.
  doi: 10.1253/circj.CJ-13-1365
– volume: 43
  start-page: D789
  year: 2015
  ident: 27953_CR35
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku1205
– volume: 177
  start-page: 1022
  year: 2019
  ident: 27953_CR11
  publication-title: Cell
  doi: 10.1016/j.cell.2019.04.014
– volume: 22
  start-page: 665
  year: 2015
  ident: 27953_CR81
  publication-title: Commun. Stat. Appl. Methods
– volume: 24
  start-page: 14
  year: 2019
  ident: 27953_CR2
  publication-title: Int. J. Cardiol. Heart Vasc.
– ident: 27953_CR69
– ident: 27953_CR83
  doi: 10.5281/zenodo.5080229
– volume: 9
  year: 2018
  ident: 27953_CR16
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05512-x
– volume: 50
  start-page: 1219
  year: 2018
  ident: 27953_CR6
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0183-z
– volume: 7
  start-page: e35788
  year: 2018
  ident: 27953_CR70
  publication-title: eLife
  doi: 10.7554/eLife.35788
– volume: 44
  start-page: 2192
  year: 2004
  ident: 27953_CR49
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2004.08.058
– ident: 27953_CR28
– volume: 9
  start-page: 1
  year: 2020
  ident: 27953_CR80
  publication-title: eLife
  doi: 10.7554/eLife.52155
– volume: 126
  start-page: 350
  year: 2020
  ident: 27953_CR40
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.119.315179
– volume: 2011
  start-page: bar030
  year: 2011
  ident: 27953_CR66
  publication-title: Database
  doi: 10.1093/database/bar030
– volume: 25
  start-page: 1841
  year: 2009
  ident: 27953_CR59
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp328
– volume: 26
  start-page: 2363
  year: 2010
  ident: 27953_CR65
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq431
– volume: 4
  start-page: 530
  year: 2018
  ident: 27953_CR31
  publication-title: Hear. Case Rep.
– volume: 126
  start-page: 200
  year: 2020
  ident: 27953_CR7
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.119.315686
– volume: 3
  start-page: 25
  year: 2016
  ident: 27953_CR34
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2016.00025
– volume: 6
  start-page: 169
  year: 2018
  ident: 27953_CR1
  publication-title: Pulse
  doi: 10.1159/000496150
– volume: 7
  start-page: 500
  year: 2012
  ident: 27953_CR17
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2011.457
– volume: 28
  start-page: 1353
  year: 2012
  ident: 27953_CR76
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bts163
– ident: 27953_CR84
  doi: 10.5281/zenodo.5094276
– volume: 165
  start-page: 535
  year: 2016
  ident: 27953_CR23
  publication-title: Cell
  doi: 10.1016/j.cell.2016.03.014
– volume: 95
  start-page: 194
  year: 2014
  ident: 27953_CR21
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2014.07.005
– volume: 43
  start-page: 67
  year: 2019
  ident: 27953_CR33
  publication-title: Can. J. Diabetes
  doi: 10.1016/j.jcjd.2018.05.007
– volume: 15
  start-page: e8513
  year: 2019
  ident: 27953_CR24
  publication-title: Mol. Syst. Biol.
  doi: 10.15252/msb.20188513
– volume: 25
  start-page: 25
  year: 2000
  ident: 27953_CR78
  publication-title: Nat. Genet.
  doi: 10.1038/75556
– volume: 8
  year: 2017
  ident: 27953_CR30
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01747-2
– volume: 17
  year: 2016
  ident: 27953_CR68
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-0974-4
– volume: 10
  start-page: 806
  year: 2019
  ident: 27953_CR26
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2019.00806
– volume: 18
  year: 2017
  ident: 27953_CR55
  publication-title: Genome Biol.
  doi: 10.1186/s13059-017-1286-z
– volume: 526
  start-page: 75
  year: 2015
  ident: 27953_CR64
  publication-title: Nature
  doi: 10.1038/nature15394
– volume: 37
  start-page: 2893
  year: 2016
  ident: 27953_CR54
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehw210
– volume: 5
  start-page: 1564
  year: 2010
  ident: 27953_CR61
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2010.116
– volume: 50
  start-page: 1225
  year: 2018
  ident: 27953_CR3
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0133-9
– volume: 5
  start-page: e1000529
  year: 2009
  ident: 27953_CR62
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1000529
– volume: 347
  start-page: 664
  year: 2015
  ident: 27953_CR14
  publication-title: Science
  doi: 10.1126/science.1260793
– volume: 26
  start-page: 139
  year: 2010
  ident: 27953_CR82
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btp616
– volume: 30
  start-page: 2811
  year: 2014
  ident: 27953_CR85
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu393
– volume: 9
  year: 2018
  ident: 27953_CR37
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03714-x
– volume: 100
  start-page: 9440
  year: 2003
  ident: 27953_CR20
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1530509100
– ident: 27953_CR48
– volume: 501
  start-page: 506
  year: 2013
  ident: 27953_CR18
  publication-title: Nature
  doi: 10.1038/nature12531
– volume: 51
  start-page: 323
  year: 2019
  ident: 27953_CR36
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00012.2019
– volume: 46
  start-page: D267
  year: 2018
  ident: 27953_CR71
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1092
– volume: 2
  start-page: 306
  year: 2009
  ident: 27953_CR29
  publication-title: Circ. Cardiovasc. Genet.
  doi: 10.1161/CIRCGENETICS.108.846733
– volume: 85
  start-page: 207
  year: 2015
  ident: 27953_CR57
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2015.06.005
– volume: 31
  start-page: 1119
  year: 2013
  ident: 27953_CR32
  publication-title: Int. J. Mol. Med.
  doi: 10.3892/ijmm.2013.1316
– volume: 47
  start-page: D330
  year: 2019
  ident: 27953_CR79
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky1055
– volume: 23
  start-page: 89
  year: 2014
  ident: 27953_CR53
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddu328
– volume: 51
  start-page: 585
  year: 2008
  ident: 27953_CR56
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2007.09.055
– volume: 6
  start-page: 127
  year: 2019
  ident: 27953_CR5
  publication-title: Front. Cardiovasc. Med.
  doi: 10.3389/fcvm.2019.00127
– ident: 27953_CR58
– volume: 8
  year: 2017
  ident: 27953_CR13
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14357
– volume: 7
  year: 2016
  ident: 27953_CR44
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11303
– volume: 46
  start-page: D794
  year: 2018
  ident: 27953_CR75
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1081
– volume: 102
  start-page: 15545
  year: 2005
  ident: 27953_CR27
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 30
  start-page: 520
  year: 2015
  ident: 27953_CR50
  publication-title: Rev. Bras. Cir. Cardiovasc.
– volume: 47
  start-page: D766
  year: 2019
  ident: 27953_CR72
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gky955
– volume: 10
  year: 2019
  ident: 27953_CR8
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12721-5
– ident: 27953_CR12
– volume: 109
  start-page: 527
  year: 2016
  ident: 27953_CR41
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvw007
– volume: 33
  start-page: 1113
  year: 2015
  ident: 27953_CR51
  publication-title: Stem Cells
  doi: 10.1002/stem.1923
– volume: 107
  start-page: 252
  year: 2005
  ident: 27953_CR39
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2005.03.005
– volume: 9
  start-page: e1003118
  year: 2013
  ident: 27953_CR60
  publication-title: PLoS Comput. Biol.
  doi: 10.1371/journal.pcbi.1003118
– volume: 31
  start-page: 1334
  year: 2015
  ident: 27953_CR77
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu779
– volume: 27
  start-page: 1133
  year: 2008
  ident: 27953_CR52
  publication-title: Stat. Med.
  doi: 10.1002/sim.3034
– volume: 50
  start-page: 956
  year: 2018
  ident: 27953_CR19
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0154-4
– volume: 51
  start-page: 1506
  year: 2019
  ident: 27953_CR38
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0499-3
– volume: 4
  start-page: e001808
  year: 2015
  ident: 27953_CR43
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.115.001808
SSID ssj0000391844
Score 2.505057
Snippet Genome-wide association studies (GWAS) for atrial fibrillation (AF) have uncovered numerous disease-associated variants. Their underlying molecular mechanisms,...
Numerous disease-associated variants have been described in GWAS for atrial fibrillation. Here the authors integrate omics data to investigate the consequences...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 441
SubjectTerms 631/114/2114
631/208/199
631/208/205/2138
631/208/212
631/45/475
Atria
Atrial Fibrillation - genetics
Cardiac arrhythmia
Cardiovascular diseases
Fibrillation
Gene expression
Gene Expression Regulation
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
Genome-wide association studies
Genome-Wide Association Study
Genomics
Homeobox Protein Nkx-2.5 - genetics
Homeobox Protein Nkx-2.5 - metabolism
Humanities and Social Sciences
Humans
Molecular modelling
multidisciplinary
Nkx2.5 protein
Organ Specificity
Polymorphism, Single Nucleotide - genetics
Proteins
Proteomics
Quantitative trait loci
Quantitative Trait Loci - genetics
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
Transcriptomics
SummonAdditionalLinks – databaseName: Biological science database
  dbid: M7P
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELaggMSFd-lCQUHiBlb9SuyIAwJExQFVPeyhN8t2bKhUJWWzReq_Z8bxploevXCN7cj2zNgznplvCHmtlGMyYnArCxoMFJmoU6qjpjFadHAcipjR9b_qoyNzctIelwe3sYRVbs7EfFB3Q8A38gPRINY4h_vm_fkPilWj0LtaSmjcJLcQJUHm0L3j-Y0F0c-NUiVXhklzMKp8MmAIu9BtLSnfuo8ybP_fdM0_QyZ_85vm6-jw_v8u5AG5VxTR6sPEOQ_Jjdg_Inem0pSXj8m7ZaYIxUxMjCaqcuQhxRzmsXIFyaQaUuVy3Y8qYerA2RRY94QsDz8vP32hpdACDWC_rKkxncOcn87FxklmOuGSk64DWQXzOYCS47QLjAcpE5hrCugneWp9ilFj_fRdstMPfdwjlQi-TTyAlhi8Cpp572MjQu071zY-ygXhm922oYCQYy2MM5ud4dLYiUIWKGQzhSxfkDfzmPMJguPa3h-RiHNPhM_OH4bVN1uk0dasSaaNoEy6WjWgIzuZQBeumeqApz1Mc39DO1tkerRXhFuQV3MzSCO6WFwfh4vcR8CF32r4xdOJY-aZSMQG5ApG6y1e2prqdkt_-j0jfhudDeMFebvhuqtp_Xsrnl2_iufkrkBBYJwKvk921quL-ILcDj_Xp-PqZZakX9CiJHk
  priority: 102
  providerName: ProQuest
Title Tissue-specific multi-omics analysis of atrial fibrillation
URI https://link.springer.com/article/10.1038/s41467-022-27953-1
https://www.ncbi.nlm.nih.gov/pubmed/35064145
https://www.proquest.com/docview/2621821415
https://www.proquest.com/docview/2622284973
https://pubmed.ncbi.nlm.nih.gov/PMC8782899
https://doaj.org/article/506f89e324a546999a3f013504dbecb3
Volume 13
WOSCitedRecordID wos000745537800009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: Directory of Open Access Journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: DOA
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M~E
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Biological Science Database (Proquest)
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M7P
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection (Proquest)
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: 7X7
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest advanced technologies & aerospace journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: P5Z
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/hightechjournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: BENPR
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database (Proquest)
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: PIMPY
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwEB1BAYkL4pvQsgoSN7Dqr8S2ONGqFUiwitAeFi6W49hqpSqLulsk_j1jJ7vtAoULlxxiO7Gex_aM_PwG4JWUjoqQyK3UKwxQRCROyo7oWive4XLIQ1bX_6imUz2fm-ZKqq_ECRvkgQfg9itaR20C7vuuwlDOGCciui0VlR3-vs06n-j1XAmm8hosDIYucrwlQ4XeX8q8JiTyOlemEoRt7URZsP9PXubvZMlfTkzzRnR8H-6NHmT5buj5A7gR-odwZ8gp-eMRvJ1lKEm6QploQGWmDJJ0-XhZulGCpFzE0uWEHWVMnP-zgRH3GGbHR7PD92TMkEA8Bh4ronXn0mWdzoXaCao77qITrsNJhnGvR-_EKecp80JEjLMkAi9YNG0MQaXE509gp1_04RmU3LcmMo_unW-lV7Rt21BzX7WdM3UbRAFsDZb1o3p4SmJxZvMpttB2ANgiwDYDbFkBrzdtvg3aGX-tfZDGYFMz6V7nF2gNdrQG-y9rKGBvPYJ2nIxLy-skU8_QVSng5aYYp1E6G3F9WFzkOhx3aqPwE0-HAd_0RCRRPyaxtdoyha2ubpf0pydZqlurHNEW8GZtNJfduh6K5_8Dil24y5O1U0Y424Od1flFeAG3_ffV6fJ8AjfVXOWnnsCtg6Np83mSp9AksV8bfDbVVyxpPnxqvvwEvPcc7A
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAoIL78dCgSDBiVqNH4kdIYR4Va26rHrYQ2-W49hQqUrKZgvqj-I_MnYe1fLorQeuiRNNnM_jGc_MNwAvhDApdyG5NbUSHRTuiRGiIipXklWoDpmL7PpTOZupg4Nifw1-DrUwIa1y0IlRUVeNDWfkWywPXOMU95u3x99I6BoVoqtDC40OFnvu9Ae6bO2b3Y_4f18ytv1p_mGH9F0FiEVjfUmUqkwocKmMyw1PVcWMN9xUCEz0FS3u6EYam1LLuUffRKCwnPqi9M7J0CwcX3sJLqMVwVTMFNwfj3QC2boSoi_NSbnaakVURCFjnski44SubH-xS8DfTNs_MzR_C9PG3W_75n82b7fgRm9mJ--6dXEb1lx9B652jTdP78LrecQbCXWmIVcqiXmVJFRot4npeVqSxicmdjVJfCiMOOrSBu_B_CIEvw_rdVO7h5AwWxaeWrSBbSmsTMuydDmzWVmZIi8dnwAdfq62PcV66PRxpGOonyvdAUIjIHQEhKYTeDU-c9wRjJw7-n3AzDgykIPHC83ii-51jc7S3KvCoalsMpGjB2C4R0s_S0WFK7ZEMTcGqOheY7X6DCcTeD7eRl0TAkimds1JHMPQnCkkvuJBB9BREh6YD6nAp-UKdFdEXb1TH36NfOZKRrd_ApsDyM_E-vdUPDr_K57BtZ3556me7s72HsN1FtZgSgmjG7C-XJy4J3DFfl8etouncREnoC8Y_L8AV3mBoA
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKgYoL78JCgSDBCayNH4kdIYSAsqJqtdrDHnqzHMeGSlVSNltQfxr_jhkn2Wp59NYD140TzSafxzP2N98Q8kJKmwqP5NbUKUhQRKBWyorqXCtegTvkPqrrH6jpVB8eFrMN8nOohUFa5eATo6OuGod75GOeo9Y4g_VmHHpaxGx38u7kG8UOUnjSOrTT6CCy789-QPrWvt3bhW_9kvPJp_nHz7TvMEAdBO5LqnVlsdilsj63ItUVt8EKWwFIIW90sLpbZV3KnBAB8hQJhgsWijJ4r7BxODz2CrmqULM8sgZnq-0dFF7XUvZlOqnQ41ZGp4Tsea6KTFC2thTGjgF_C3P_ZGv-dmQbV8LJrf_4Hd4mN_vwO3nfzZc7ZMPXd8n1riHn2T3yZh5xSLH-FDlUSeRbUqzcbhPb67ckTUhs7HaSBCyYOO7ohPfJ_DIM3yabdVP7hyThriwCcxAbu1I6lZZl6XPusrKyRV56MSJs-NDG9dLr2AHk2EQKgNCmA4cBcJgIDsNG5NXqnpNOeOTC0R8QP6uRKBoef2gWX0zvg0yW5kEXHkJom8kcMgMrAmQAWSormMklmLkzwMb0nqw155gZkeery-CD8GDJ1r45jWM4hDmFgkc86MC6skSgIiKTcLdag_GaqetX6qOvUedcq7gdMCKvB8Cfm_XvV_Ho4n_xjGwB5s3B3nT_MbnBcTqmjHK2QzaXi1P_hFxz35dH7eJpnM8JMZeM_V8qC4pd
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tissue-specific+multi-omics+analysis+of+atrial+fibrillation&rft.jtitle=Nature+communications&rft.au=Assum%2C+Ines&rft.au=Krause%2C+Julia&rft.au=Scheinhardt%2C+Markus+O.&rft.au=M%C3%BCller%2C+Christian&rft.date=2022-01-21&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=13&rft_id=info:doi/10.1038%2Fs41467-022-27953-1&rft_id=info%3Apmid%2F35064145&rft.externalDocID=PMC8782899
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon