MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era

Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening the control of MDR tuberculosis (MDR-TB) in Eswatini. Methods We investigate the ev...

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Bibliographic Details
Published in:	Genome medicine Vol. 12; no. 1; p. 104
Main Authors:	Beckert, Patrick, Sanchez-Padilla, Elisabeth, Merker, Matthias, Dreyer, Viola, Kohl, Thomas A., Utpatel, Christian, Köser, Claudio U., Barilar, Ivan, Ismail, Nazir, Omar, Shaheed Vally, Klopper, Marisa, Warren, Robin M., Hoffmann, Harald, Maphalala, Gugu, Ardizzoni, Elisa, de Jong, Bouke C., Kerschberger, Bernhard, Schramm, Birgit, Andres, Sönke, Kranzer, Katharina, Maurer, Florian P., Bonnet, Maryline, Niemann, Stefan
Format:	Journal Article
Language:	English
Published:	London BioMed Central 25.11.2020 BioMed Central Ltd Springer Nature B.V
Subjects:	Antitubercular Agents Archives & records Bacterial Proteins Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Research Clofazimine Clone Cells Diarylquinolines Disease Outbreaks DNA sequencing Drug resistance Drug resistance in microorganisms Eswatini Ethics Genetics Genomes Genomics Human Genetics Humans Laboratories Life Sciences Medicine/Public Health Metabolomics Microbial Sensitivity Tests Multidrug resistance Multidrug resistant organisms Mutation Mycobacterium tuberculosis Nucleotide sequencing Outbreaks Phylogenetics RpoB protein Statistical analysis Surveys Systems Biology The impact of genomics on precision public health Tuberculosis Tuberculosis, Multidrug-Resistant Whole genome sequencing Belgium South Africa Eswatini Tuberculosis MDR outbreak strains Multidrug resistance Diagnostice escape Treatment failure Resistance evolution Treatment escape
ISSN:	1756-994X, 1756-994X
Online Access:	Get full text
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