MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era

Background Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening the control of MDR tuberculosis (MDR-TB) in Eswatini. Methods We investigate the ev...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Genome medicine Ročník 12; číslo 1; s. 104
Hlavní autoři:	Beckert, Patrick, Sanchez-Padilla, Elisabeth, Merker, Matthias, Dreyer, Viola, Kohl, Thomas A., Utpatel, Christian, Köser, Claudio U., Barilar, Ivan, Ismail, Nazir, Omar, Shaheed Vally, Klopper, Marisa, Warren, Robin M., Hoffmann, Harald, Maphalala, Gugu, Ardizzoni, Elisa, de Jong, Bouke C., Kerschberger, Bernhard, Schramm, Birgit, Andres, Sönke, Kranzer, Katharina, Maurer, Florian P., Bonnet, Maryline, Niemann, Stefan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 25.11.2020 BioMed Central Ltd Springer Nature B.V
Témata:	Antitubercular Agents Archives & records Bacterial Proteins Bioinformatics Biomedical and Life Sciences Biomedicine Cancer Research Clofazimine Clone Cells Diarylquinolines Disease Outbreaks DNA sequencing Drug resistance Drug resistance in microorganisms Eswatini Ethics Genetics Genomes Genomics Human Genetics Humans Laboratories Life Sciences Medicine/Public Health Metabolomics Microbial Sensitivity Tests Multidrug resistance Multidrug resistant organisms Mutation Mycobacterium tuberculosis Nucleotide sequencing Outbreaks Phylogenetics RpoB protein Statistical analysis Surveys Systems Biology The impact of genomics on precision public health Tuberculosis Tuberculosis, Multidrug-Resistant Whole genome sequencing Belgium South Africa Eswatini Tuberculosis MDR outbreak strains Multidrug resistance Diagnostice escape Treatment failure Resistance evolution Treatment escape
ISSN:	1756-994X, 1756-994X
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!