Optical control of protein phosphatase function

Protein phosphatases are involved in embryonic development, metabolic homeostasis, stress response, cell cycle transitions, and many other essential biological mechanisms. Unlike kinases, protein phosphatases remain understudied and less characterized. Traditional genetic and biochemical methods hav...

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Veröffentlicht in:	Nature communications Jg. 10; H. 1; S. 4384 - 10
Hauptverfasser:	Courtney, Taylor M., Deiters, Alexander
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 26.09.2019 Nature Publishing Group Nature Portfolio
Schlagworte:	13/106 13/95 14/35 631/1647/2253 631/92/458/1733 631/92/552 631/92/612 631/92/612/1246 82/80 96/63 Active control Catalysis Catalytic activity Cell cycle Cellular stress response Dual Specificity Phosphatase 6 - chemistry Dual Specificity Phosphatase 6 - genetics Dual Specificity Phosphatase 6 - metabolism Embryogenesis Embryonic growth stage Enzyme Activation - radiation effects Extracellular signal-regulated kinase Genetic code HEK293 Cells Homeostasis Humanities and Social Sciences Humans Kinases Luminescent Proteins - chemistry Luminescent Proteins - genetics Luminescent Proteins - metabolism Lysine Microscopy, Fluorescence multidisciplinary Mutation Nuclear transport Optical control Optogenetics - methods Phosphatase Protein interaction Protein phosphatase Proteins Science Science (multidisciplinary) Substrates Time-Lapse Imaging - methods Translocation Ultraviolet Rays
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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