Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson’s disease

In Parkinson’s disease (PD) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (DA) and glutamate (Glu) levels change, resulting in dysfunction of basal ganglia motor regulation. The PD patient presents motor dysfunction such as resting tremor, bradyk...

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Vydáno v:	Experimental brain research Ročník 240; číslo 6; s. 1713 - 1725
Hlavní autoři:	Wang, Xiaodong, Wang, Yinhao, Chen, Jian, Li, Juan, Liu, Yang, Chen, Wei
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2022 Springer Springer Nature B.V
Témata:	6-Hydroxydopamine Aerobic exercise Aerobic exercises Aerobics Analysis Animals Basal ganglia Biomedical and Life Sciences Biomedicine Bradykinesia Care and treatment Caudate-putamen Cellular signal transduction Chronic illnesses Complications and side effects Disease Diseases Dopamine Dopamine D2 receptors Dopamine receptors Exercise Exercise therapy Extracellular signal-regulated kinase Gait Glutamate Immunofluorescence Intervention Kinases MAP kinase Motor ability Movement disorders Neostriatum Neurodegenerative diseases Neurology Neurons Neurosciences Open-field behavior Parkinson's disease Phosphorylation Physical fitness Physiological aspects Prince Edward Island Prodynorphin Proenkephalin Protein kinase Protein kinases Psychological aspects Research Article Resting Risk factors Signal transduction Signaling Spiny neurons Substantia nigra Tests Tremor Washington, D.C Prince Edward Island Washington, D.C China Motor function Striatal medium spiny neurons Parkinson’s disease Aerobic exercise Erk/MAPK signaling
ISSN:	0014-4819, 1432-1106, 1432-1106
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Shrnutí:	In Parkinson’s disease (PD) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (DA) and glutamate (Glu) levels change, resulting in dysfunction of basal ganglia motor regulation. The PD patient presents motor dysfunction such as resting tremor, bradykinesia, and muscular rigidity. To investigate the mechanism of aerobic exercise to improve PD-related motor dysfunction, in the current study, 6-hydroxydopamine (6-OHDA) was used to induce the PD mice model, and the motor function of PD mice was comprehensively evaluated by open-field test, rotarod test, and gait test. The co-expression of prodynorphin (PDYN) and proenkephalin (PENK) with extracellular signal-regulated kinase (Erk1/2) and phosphorylation Erk1/2 (p-Erk1/2) were detected by double-labeling immunofluorescence. The results showed that a 4-week aerobic exercise intervention could effectively improve the motor dysfunction of PD mice. Moreover, it was found that the expressions of Erk1/2 and p-Erk1/2 in the dorsal striatum (Str) of PD mice were significantly increased, and the number of positive cells co-expressed by Erk1/2, p-Erk1/2, and PENK was significantly higher than PDYN. The above phenomenon was reversed by a 4-week aerobic exercise intervention. Therefore, this study suggests that the mechanism by which aerobic exercise improves PD-related motor dysfunction may be related to that the aerobic exercise intervention alleviates the activity of extracellular signal-regulated kinase/mitogen-activated protein kinases (Erk/MAPK) signaling pathway in striatal medium spiny neurons expressing D2-like receptors (D2-MSNs) of PD mice by regulating the striatal DA and Glu signaling.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Communicated by Sreedharan Sajikumar.
ISSN:	0014-4819 1432-1106 1432-1106
DOI:	10.1007/s00221-022-06360-4